G. D. Gish

Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila. (1995)

Raabe, T, Olivier, J P, Dickson, B J, Liu, X, Gish, G D, Pawson, T, ...

The Drk SH3-SH2-SH3 adaptor protein has been genetically identified in a screen for rate-limiting components acting downstream of the Sevenless (Sev) receptor tyrosine kinase in the developing eye of...

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.

Van Der Geer, P, Wiley, S, Gish, G D, Lai, V K, Stephens, R, White, M F, ...

The Shc adaptor protein contains two phosphotyrosine [Tyr(P)]binding modules--an N-terminal Tyr(P) binding (PTB) domain and a C-terminal Src homology 2 (SH2) domain. We have compared the ability of...

Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.

Payne, G, Shoelson, S E, Gish, G D, Pawson, T, Walsh, C T

Src homology 2 (SH2) domains are phosphotyrosine-binding modules found within various signal-transducing proteins. We have determined by 125I competition assay and surface plasmon resonance that the...

A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase.

Lai, K M, Olivier, J P, Gish, G D, Henkemeyer, M, McGlade, J, Pawson, T

Antibodies to the human Shc adaptor protein were used to isolate a cDNA encoding a Drosophila Shc protein (dShc) by screening an expression library. The dshc gene, which maps to position 67B-C on the...

Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

Raabe, T, Olivier, J P, Dickson, B, Liu, X, Gish, G D, Pawson, T, ...

The Drk SH3-SH2-SH3 adaptor protein has been genetically identified in a screen for rate-limiting components acting downstream of the Sevenless (Sev) receptor tyrosine kinase in the developing eye of...

Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.

Roche, S, McGlade, J, Jones, M, Gish, G D, Pawson, T, Courtneidge, S A

We have investigated the roles of the phosphotyrosine phosphatase Syp (also called SH-PTP2), phospholipase C (PLC) gamma1, rasGTPase Activating Protein (rasGAP) and the adapter molecules Nck and Shc...

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.

Holland, S J, Gale, N W, Gish, G D, Roth, R A, Songyang, Z, Cantley, L C, ...

Eph-related receptor tyrosine kinases have been implicated in the control of axonal navigation and fasciculation. To investigate the biochemical mechanisms underlying such functions, we have...

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.

Van Der Geer, P, Wiley, S, Gish, G D, Lai, V K, Stephens, R, White, M F, ...

The Shc adaptor protein contains two phosphotyrosine [Tyr(P)]binding modules--an N-terminal Tyr(P) binding (PTB) domain and a C-terminal Src homology 2 (SH2) domain. We have compared the ability of...

Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.

Payne, G, Shoelson, S E, Gish, G D, Pawson, T, Walsh, C T

Src homology 2 (SH2) domains are phosphotyrosine-binding modules found within various signal-transducing proteins. We have determined by 125I competition assay and surface plasmon resonance that the...

A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase.

Lai, K M, Olivier, J P, Gish, G D, Henkemeyer, M, McGlade, J, Pawson, T

Antibodies to the human Shc adaptor protein were used to isolate a cDNA encoding a Drosophila Shc protein (dShc) by screening an expression library. The dshc gene, which maps to position 67B-C on the...

Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

Raabe, T, Olivier, J P, Dickson, B, Liu, X, Gish, G D, Pawson, T, ...

The Drk SH3-SH2-SH3 adaptor protein has been genetically identified in a screen for rate-limiting components acting downstream of the Sevenless (Sev) receptor tyrosine kinase in the developing eye of...

Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.

Roche, S, McGlade, J, Jones, M, Gish, G D, Pawson, T, Courtneidge, S A

We have investigated the roles of the phosphotyrosine phosphatase Syp (also called SH-PTP2), phospholipase C (PLC) gamma1, rasGTPase Activating Protein (rasGAP) and the adapter molecules Nck and Shc...

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells.

Holland, S J, Gale, N W, Gish, G D, Roth, R A, Songyang, Z, Cantley, L C, ...

Eph-related receptor tyrosine kinases have been implicated in the control of axonal navigation and fasciculation. To investigate the biochemical mechanisms underlying such functions, we have...