G. E. Janka-Schaub

Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia (2007)

Nachman, J.B., Heerema, N.A., Sather, H., Camitta, B., Forestier, E., Harrison, C.J., ...

One-hundred thirty-nine patients with acute lymphoblastic leukemia (ALL) and hypodiploldly (fewer than 45 chromosomes) were collected from 10 different national ALL study groups and single...

Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia (2005)

Stams, W.A., Boer, M.L. Den, Holleman, A., Appel, I.M., Beverloo, H.B., Wering, E.R. Van, ...

Resistance to L-asparaginase in leukemic cells may be caused by an elevated cellular expression of asparagine synthetase (AS). Previously, we reported that high AS expression did not correlate to...

Decreased PARP and procaspase-2 protein levels are associated with cellular drug resistance in childhood acute lymphoblastic leukemia (2005)

Holleman, A., Boer, M.L. Den, Kazemier, K.M., Beverloo, H.B., Von Bergh, A.R., Janka-Schaub, G.E., ...

Drug resistance in childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) is associated with impaired ability to induce apoptosis. To elucidate causes of apoptotic defects, we...

Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment (2004)

Holleman, A., Cheng, C., Pui, C.H., Evans, W.E., Relling, M.V., Pieters, R., ...

BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy in approximately 80 percent of patients. However, the cause of treatment failure in the remaining 20 percent of...

Resistance to different classes of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia (2003)

Holleman, A., Boer, M.L. Den, Kazemier, K.M., Janka-Schaub, G.E., Pieters, R.

Resistance of leukemic cells to chemotherapeutic agents is associated with an unfavorable outcome in pediatric acute lymphoblastic leukemia (ALL). To investigate the underlying mechanisms of cellular...

Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia (2003)

Stam, R.W., Boer, M.L. Den, Meijerink, J.P., Ebus, M.E., Peters, G.J., Noordhuis, P., ...

Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of mixed lineage leukemia (MLL) gene rearrangements, a poor outcome, and resistance to chemotherapeutic drugs. One...

Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL (2003)

Stams, W.A., Boer, M.L. Den, Beverloo, H.B., Meijerink, J.P., Stigter, R.L., Wering, E.R. Van, ...

The (12;21) translocation resulting in TEL/AML1 gene fusion is present in about 25% of childhood precursor B-lineage acute lymphoblastic leukemia (ALL) and is associated with a good prognosis and a...

Cell proliferation is related to in vitro drug resistance in childhood acute leukaemia

Kaaijk, P, Kaspers, G J L, Van Wering, E R, Broekema, G J, Loonen, A H, Hählen, K, ...