Humbert, G., Wadsworth, W. J., Leon-Saval, S. G., Knight, J. C., Birks, T. A., Russell, P. S. J., ...
Hollow core photonic crystal fibers for beam delivery (2004)
Humbert, G., Knight, J. C., Bouwmans, G., Russell, P. S., Williams, D. P., Roberts, P. J., ...
Operation of the clio accelerator (1993)
Chaput, R., Glotin, F., Humbert, G., Kergosien, B., Lesrel, J., Ortega, J.M., ...
Operation of the clio accelerator (1993)
Chaput, R., Glotin, F., Humbert, G., Kergosien, B., Lesrel, J., Ortega, J.M., ...
Lack of effect of ketoprofen on the pharmacokinetics of pefloxacin and ofloxacin (1993)
FILLASTRE, J. P., LEROY, A., BORSA-LEBAS, F., ETIENNE, I., GY, C., HUMBERT, G.
Mouton, Y., Chidiac, C., Humbert, G., Leroy, J., Veyssier, P., Modai, J., ...
Multi-resistant strains of Gram-negative bacteria are rapidly emerging as a frequent cause of serious bacterial infection in the hospital environment. Effective treatment must include an antibiotic...
First lasing of the clio fel (1992)
Glotin, F., Berzet, J.M., Chaput, R., Kergosien, B., Humbert, G., Jaroszinsky, D., ...
First lasing of the clio fel (1992)
Glotin, F., Berzet, J.M., Chaput, R., Kergosien, B., Humbert, G., Jaroszinsky, D., ...
Pharmacokinetics of quinolones in renal insufficiency (1990)
Fillastre, J. P., Leroy, A., Moulin, B., Dhib, M., Borsa-Lebas, F., Humbert, G.
The pharmacokinetics of the new fluoroquinolone derivatives have been extensively studied in patients with various degrees of chronic renal insufficiency during the last few years. Their kinetic...
Humbert, G., Kappler, F., Martini, M., Norvez, G., Rimpault, G., Ruelle, B., ...
Nuclear Science and Engineering, 87(1984) S.233-51
Pharmacokinetics of ceftazidime in renal failure (1983)
FILLASTRE, J.P., HUMBERT, G., OLIER, B., LEGUY, F., BORSA, F., SPENSER, G.R.
Pharmacokinetics of cefadroxil in patients with impaired renal function (1982)
Leroy, A., Humbert, G., Godin, M., Fillastre, J. P.
The pharmacokinetics of cefadroxil were studied in patients with different degrees of renal impairment after a single oral dose of 1000 mg. The standard open one-compartment model was used to...
The RACINE programme. Physics and safety studies in heterogeneous configurations. (1982)
Scholtyssek, W., Humbert, G., Martini, M.
Jahrestagung Kerntechnik 82. Reaktortagung 1982. Mannheim, 4.-6.Mai 1982. Kerntechnische Ges.e.V. Deutsches Atomforum e.V.
Control-rod parametrical studies in the framework of the pre-racine and racine programs. (1982)
Humbert, G., Ruelle, B., Daguzan, G., Stanculescu, A., Kappler, F., Scholtyssek, W., ...
Proc.of the Topical Meeting on Advances in Reactor Physics and Core Thermal Hydraulics, Kiamesha Lake, N.Y., September 22-24, 1982 NUREG/CP-0034 (1982) Vol.1 S.148-61
Scholtyssek, W., Daguzan, G., Humbert, G., Martini, M., Ruelle, B., Kappler, F., ...
Proc.of the Topical Meeting on Advances in Reactor Physics and Core Thermal Hydraulics, Kiamesha Lake, N.Y., September 22-24, 1982 NUREG/CP-0034 (1982) Vol.1 S.133-47
Pharmacokinetics of cefotaxime in subjects with normal and impaired renal function (1980)
Fillastre, J. P., Leroy, A., Humbert, G., Godin, M.
The pharmacokinetics of cefotaxime was investigated in 6 healthy subjects and in 22 uraemic patients with various degrees of renal insufficiency. After i.v. bolus injection of a single 15 mg/kg dose,...
Pharmacokinetics of dibekacin in normal subjects and in patients with renal failure (1980)
Leroy, A., Humbert, G., Fillastre, J. P.
A pharmacokinetic study of dibekacin, 3′-4′-4-dideoxykanamycin B, was conducted in 5 healthy subjects and 23 subjects with chronic renal failure. After i.v. bolus injection and i.m. injection of...
Pharmacokinetics of cefoxitin sodium in normal subjects and in uraemic patients (1978)
Fillastre, J. P, Leroy, A., Godin, M., Oksenhendler, G., Humbert, G.
Pharmacokinetics data of cefoxitin sodium were determined in normal subjects and in uraemic patients. All subjects (5 normal and 20 uraemic) received 30 mg/kg of cefoxitin i.v. in 30-min. infusions....
3 v.
vii, 493 p.
Cefixime penetration in human renal parenchyma.
Leroy, A, Oser, B, Grise, P, Humbert, G
The diffusion of cefixime, a new orally active expanded-spectrum cephalosporin, was studied in 12 patients undergoing nephrectomy after receiving 200-mg oral doses every 12 h for 2 days. The patients...
Caron, F, Bouaniche, M, Delatour, F, Ducrotte, P, Torlotin, J C, Denis, P, ...
Fourteen-membered macrolides are known to produce alterations in digestive tract motor activity; these include the induction of strong gastric contractions and a decrease in the motility of the small...
Lomefloxacin pharmacokinetics in subjects with normal and impaired renal function.
Leroy, A, Fillastre, J P, Humbert, G
Lomefloxacin pharmacokinetics were investigated in 6 normal subjects and 24 uremic patients after a single oral dose of 400 mg. In subjects with normal renal function, the peak level in plasma...
Thauvin, C, Lemeland, J F, Humbert, G, Fillastre, J P
The efficacies of pefloxacin, fosfomycin, and both of these agents in combination against methicillin-resistant Staphylococcus aureus were assessed in a rat endocarditis model. The combination...
Ofloxacin pharmacokinetics in renal failure.
Fillastre, J P, Leroy, A, Humbert, G
The pharmacokinetics of ofloxacin were investigated in 12 normal subjects and 21 uremic patients after the administration of a single oral 200-mg dose. An open three-compartment body model was used...
Pharmacokinetics of habekacin in patients with renal insufficiency.
Fillastre, J P, Leroy, A, Humbert, G, Moulin, B, Bernadet, P, Josse, S
The pharmacokinetics of habekacin, a new semisynthetic aminoglycoside antibiotic, were investigated in six healthy subjects and 25 uremic patients (six of whom were on hemodialysis) after...
Jouen-Beades, F, Paris, E, Dieulois, C, Lemeland, J F, Barre-Dezelus, V, Marret, S, ...
Serial flow cytometry analyses of peripheral blood mononuclear cells obtained from 8 patients infected with Listeria monocytogenes showed a higher percentage (P < 0.01) of gammadelta T cells (median,...
Pharmacokinetics of moxalactam in subjects with normal and impaired renal function.
Leroy, A, Humbert, G, Fillastre, J P
The pharmacokinetics of moxalactam were investigated in five subjects with normal renal function and 21 uremic patients. Normal subjects were given intravenous doses of 7.5 and 15 mg of the drug per...
Pharmacokinetics of ceftazidime in normal and uremic subjects.
Leroy, A, Leguy, F, Borsa, F, Spencer, G R, Fillastre, J P, Humbert, G
The pharmacokinetics of ceftazidime, administered as a single intravenous dose of 15 mg/kg given in a bolus injection over 3 min, were investigated in 5 normal subjects and in 19 uremic patients. The...
Leroy, A, Fillastre, J P, Borsa-Lebas, F, Etienne, I, Humbert, G
The pharmacokinetics of meropenem (ICI 194,660) and its open-ring metabolite (ICI 213,689) were studied in 6 healthy volunteers and 16 patients with moderate to severe renal impairment after a single...
Pharmacokinetics of Azlocillin in Subjects with Normal and Impaired Renal Function
Leroy, A., Humbert, G., Godin, M., Fillastre, J. P.
The pharmacokinetics of azlocillin were investigated in five healthy subjects and in 16 subjects with chronic renal failure. After intravenous bolus injection of a single dose of 30 mg/kg in normal...
Cefoxitin concentrations in the cerebrospinal fluids of patients with meningitis.
Humbert, G, Leroy, A, Rogez, J P, Cherubin, C
The concentrations of cefoxitin in serum and cerebrospinal fluid (CSF) were measured simultaneously in three groups of patients, 12 with aseptic meningitis (group 1) and 17 and 14 with bacterial...
Lecaillon, J B, Hirtz, J L, Schoeller, J P, Humbert, G, Vischer, W
The pharmacokinetic parameters of cefroxadin and cephalexin were compared after simultaneous oral administration of the two cephalosporins to 21 subjects. The influence of the dose, the formulation,...
Caron, F, Ducrotte, P, Lerebours, E, Colin, R, Humbert, G, Denis, P
The amoxicillin-clavulanate combination (Augmentin) frequently induces gastric complaints and diarrhea by an unknown mechanism. The aim of this study was to assess the effects of two orally...
Pharmacokinetics of Netilmicin in the Presence of Normal or Impaired Renal Function
Humbert, G., Leroy, A., Fillastre, J. P., Oksenhendler, G.
A pharmacokinetic study of netilmicin was conducted in 12 healthy subjects and 24 subjects with chronic renal failure. After intramuscular administrations of 2 and 3 mg of netilmicin per kg in normal...
Lebreton, J P, Joisel, F, Raoult, J P, Lannuzel, B, Rogez, J P, Humbert, G
A nonspecific opsonin function has been ascribed to human alpha 2 HS glycoprotein. Its serum level has been shown to be decreased in trauma patients. Recent studies from this laboratory revealed a...
Acute Renal Failure Associated with Combined Gentamicin and Cephalothin Therapy
Fillastre, J. P., Laumonier, R., Humbert, G., Dubois, D., Metayer, J., Delpech, A., ...
Three patients with normal renal function developed acute renal failure between the ninth and twenty-seventh days of combined gentamicin and cephalothin therapy. The dose of gentamicin (4-6...
Cefixime penetration in human renal parenchyma.
Leroy, A, Oser, B, Grise, P, Humbert, G
The diffusion of cefixime, a new orally active expanded-spectrum cephalosporin, was studied in 12 patients undergoing nephrectomy after receiving 200-mg oral doses every 12 h for 2 days. The patients...
Caron, F, Bouaniche, M, Delatour, F, Ducrotte, P, Torlotin, J C, Denis, P, ...
Fourteen-membered macrolides are known to produce alterations in digestive tract motor activity; these include the induction of strong gastric contractions and a decrease in the motility of the small...
Lomefloxacin pharmacokinetics in subjects with normal and impaired renal function.
Leroy, A, Fillastre, J P, Humbert, G
Lomefloxacin pharmacokinetics were investigated in 6 normal subjects and 24 uremic patients after a single oral dose of 400 mg. In subjects with normal renal function, the peak level in plasma...
Thauvin, C, Lemeland, J F, Humbert, G, Fillastre, J P
The efficacies of pefloxacin, fosfomycin, and both of these agents in combination against methicillin-resistant Staphylococcus aureus were assessed in a rat endocarditis model. The combination...
Ofloxacin pharmacokinetics in renal failure.
Fillastre, J P, Leroy, A, Humbert, G
The pharmacokinetics of ofloxacin were investigated in 12 normal subjects and 21 uremic patients after the administration of a single oral 200-mg dose. An open three-compartment body model was used...
Pharmacokinetics of habekacin in patients with renal insufficiency.
Fillastre, J P, Leroy, A, Humbert, G, Moulin, B, Bernadet, P, Josse, S
The pharmacokinetics of habekacin, a new semisynthetic aminoglycoside antibiotic, were investigated in six healthy subjects and 25 uremic patients (six of whom were on hemodialysis) after...
Jouen-Beades, F, Paris, E, Dieulois, C, Lemeland, J F, Barre-Dezelus, V, Marret, S, ...
Serial flow cytometry analyses of peripheral blood mononuclear cells obtained from 8 patients infected with Listeria monocytogenes showed a higher percentage (P < 0.01) of gammadelta T cells (median,...
Pharmacokinetics of moxalactam in subjects with normal and impaired renal function.
Leroy, A, Humbert, G, Fillastre, J P
The pharmacokinetics of moxalactam were investigated in five subjects with normal renal function and 21 uremic patients. Normal subjects were given intravenous doses of 7.5 and 15 mg of the drug per...
Pharmacokinetics of ceftazidime in normal and uremic subjects.
Leroy, A, Leguy, F, Borsa, F, Spencer, G R, Fillastre, J P, Humbert, G
The pharmacokinetics of ceftazidime, administered as a single intravenous dose of 15 mg/kg given in a bolus injection over 3 min, were investigated in 5 normal subjects and in 19 uremic patients. The...
Leroy, A, Fillastre, J P, Borsa-Lebas, F, Etienne, I, Humbert, G
The pharmacokinetics of meropenem (ICI 194,660) and its open-ring metabolite (ICI 213,689) were studied in 6 healthy volunteers and 16 patients with moderate to severe renal impairment after a single...
Pharmacokinetics of Azlocillin in Subjects with Normal and Impaired Renal Function
Leroy, A., Humbert, G., Godin, M., Fillastre, J. P.
The pharmacokinetics of azlocillin were investigated in five healthy subjects and in 16 subjects with chronic renal failure. After intravenous bolus injection of a single dose of 30 mg/kg in normal...
Cefoxitin concentrations in the cerebrospinal fluids of patients with meningitis.
Humbert, G, Leroy, A, Rogez, J P, Cherubin, C
The concentrations of cefoxitin in serum and cerebrospinal fluid (CSF) were measured simultaneously in three groups of patients, 12 with aseptic meningitis (group 1) and 17 and 14 with bacterial...
Lecaillon, J B, Hirtz, J L, Schoeller, J P, Humbert, G, Vischer, W
The pharmacokinetic parameters of cefroxadin and cephalexin were compared after simultaneous oral administration of the two cephalosporins to 21 subjects. The influence of the dose, the formulation,...
Caron, F, Ducrotte, P, Lerebours, E, Colin, R, Humbert, G, Denis, P
The amoxicillin-clavulanate combination (Augmentin) frequently induces gastric complaints and diarrhea by an unknown mechanism. The aim of this study was to assess the effects of two orally...
Pharmacokinetics of Netilmicin in the Presence of Normal or Impaired Renal Function
Humbert, G., Leroy, A., Fillastre, J. P., Oksenhendler, G.
A pharmacokinetic study of netilmicin was conducted in 12 healthy subjects and 24 subjects with chronic renal failure. After intramuscular administrations of 2 and 3 mg of netilmicin per kg in normal...
Lebreton, J P, Joisel, F, Raoult, J P, Lannuzel, B, Rogez, J P, Humbert, G
A nonspecific opsonin function has been ascribed to human alpha 2 HS glycoprotein. Its serum level has been shown to be decreased in trauma patients. Recent studies from this laboratory revealed a...
Acute Renal Failure Associated with Combined Gentamicin and Cephalothin Therapy
Fillastre, J. P., Laumonier, R., Humbert, G., Dubois, D., Metayer, J., Delpech, A., ...
Three patients with normal renal function developed acute renal failure between the ninth and twenty-seventh days of combined gentamicin and cephalothin therapy. The dose of gentamicin (4-6...
Ramzaoui, S, Jouen-Beades, F, Michot, F, Borsa-Lebas, F, Humbert, G, Tron, F
Since lymphoid organs constitute the site of active and progressive HIV disease, analysis of their lymphocytes may provide more accurate information on T cell abnormalities than that obtained from...
Pharmacokinetics of tinidazole in chronic renal failure and in patients on haemodialysis.
Flouvat, B L, Imbert, C, Dubois, D M, Temperville, B P, Roux, A F, Chevalier, G C, ...
The pharmacokinetics of tinidazole after infusion (800 mg in 15 min) were studied in 12 patients with chronic renal failure (RI) and in five patients undergoing regular dialysis treatment (RD)....