Bowley, K.A., Morton, M.J., Hunter, M., Sandle, G.I.
BACKGROUND: Aldosterone has a rapid, non-genomic, inhibitory effect on macroscopic basolateral K+ conductance in the human colon, reducing its capacity for Cl− secretion. The molecular identity of...
Bowley, K.A., Morton, M.J., Hunter, M., Sandle, G.I.
BACKGROUND: Aldosterone has a rapid, non-genomic, inhibitory effect on macroscopic basolateral K+ conductance in the human colon, reducing its capacity for Cl− secretion. The molecular identity of...
Bowley, K.A., Morton, M.J., Hunter, M., Sandle, G.I.
BACKGROUND: Aldosterone has a rapid, non-genomic, inhibitory effect on macroscopic basolateral K+ conductance in the human colon, reducing its capacity for Cl− secretion. The molecular identity of...
Properties and regulation of basolateral K+ channels in rat duodenal crypts.
McNicholas, C M, Fraser, G, Sandle, G I
1. Patch clamp recording techniques were used to study the properties of K+ channels in the basolateral membrane of rat duodenal crypts, and their regulation by Cl(-)-secretory agonists. 2. High...
Butterfield, I, Warhurst, G, Jones, M N, Sandle, G I
1. Chronic dietary K+ loading stimulates an active K+ secretory process in rat distal colon, which involves an increase in the macroscopic apical K+ conductance of surface epithelial cells. In the...
Binder, H J, McGlone, F, Sandle, G I
1. Conventional microelectrodes, the Na+ channel blocker amiloride (0.1 mM), and the K+ channel blocker tetraethylammonium chloride (TEA, 30 mM) were used to examine the effects of corticosteroid...
Flexible sigmoidoscopy in outpatients with suspected colonic disease.
Record, C O, Bramble, M G, Lishman, A H, Sandle, G I
One hundred and fifteen patients attending a gastroenterology clinic were investigated by flexible sigmoidoscopy as outpatients. There were asked to fast before the examination and give a high-volume...
Properties and regulation of basolateral K+ channels in rat duodenal crypts.
McNicholas, C M, Fraser, G, Sandle, G I
1. Patch clamp recording techniques were used to study the properties of K+ channels in the basolateral membrane of rat duodenal crypts, and their regulation by Cl(-)-secretory agonists. 2. High...
Butterfield, I, Warhurst, G, Jones, M N, Sandle, G I
1. Chronic dietary K+ loading stimulates an active K+ secretory process in rat distal colon, which involves an increase in the macroscopic apical K+ conductance of surface epithelial cells. In the...
Binder, H J, McGlone, F, Sandle, G I
1. Conventional microelectrodes, the Na+ channel blocker amiloride (0.1 mM), and the K+ channel blocker tetraethylammonium chloride (TEA, 30 mM) were used to examine the effects of corticosteroid...
Flexible sigmoidoscopy in outpatients with suspected colonic disease.
Record, C O, Bramble, M G, Lishman, A H, Sandle, G I
One hundred and fifteen patients attending a gastroenterology clinic were investigated by flexible sigmoidoscopy as outpatients. There were asked to fast before the examination and give a high-volume...
Sandle, G I, Fraser, G, Fogg, K, Warhurst, G
The HGT-1 human gastric cell line is similar to acid secreting parietal cells in that it possesses H2 receptors, histamine sensitive adenyl cyclase, and Cl- channels, which are activated by histamine...
Characterisation of oxidative injury to an intestinal cell line (HT-29) by hydrogen peroxide.
Watson, A J, Askew, J N, Sandle, G I
Reactive oxygen metabolites have been implicated in causing epithelial cell injury in colonic inflammation. A model of oxidant injury in intestinal epithelial cells has been developed in which...
Segmental variability of glucocorticoid induced electrolyte transport in rat colon.
Recent studies suggest that the ability of glucocorticoids to reduce diarrhoea in active colitis may reflect their direct effects on distal colonic electrogenic Na+ transport and water absorption, as...
Characteristics of two basolateral potassium channel populations in human colonic crypts.
Lomax, R B, Warhurst, G, Sandle, G I
The basolateral membrane of human colonic crypt cells contains Ca2+ and cAMP activated, Ba2+ blockable, low conductance (23 pS) K+ channels, which probably play an important part in intestinal Cl-...
Braganza, J M, Herman, K, Hine, P, Kay, G, Sandle, G I
We have compared the concentrations and total outputs of trypsin, amylase, and lipase secreted into the duodenum during secretin pancreozymin and Lundh Borgström tests in order to assess the...
Acute effects of dexamethasone on cation transport in colonic epithelium.
Single pharmacological doses of glucocorticoid hormones stimulate net Na+ and water absorption, K+ secretion and electrical potential difference in rat distal colon and human rectum after five hours....
Sandle, G I, Hayslett, J P, Binder, H J
The acute effects of single pharmacological doses of glucocorticoid hormones on net electrolyte and water transport and electrical potential difference (pd) in the rectum was studied in control...
Electrophysiology of the human colon: evidence of segmental heterogeneity.
Sandle, G I, Wills, N K, Alles, W, Binder, H J
The electrical properties of epithelial cell membranes in human descending and ascending colon were studied using microelectrodes and the Na channel blocker amiloride. Under control (pre-amiloride)...
Bowley, K A, Morton, M J, Hunter, M, Sandle, G I
Background: Aldosterone has a rapid, non-genomic, inhibitory effect on macroscopic basolateral K+ conductance in the human colon, reducing its capacity for Cl− secretion. The molecular identity of...
Greig, E R, Mathialahan, T, Boot-Handford, R P, Sandle, G I
Background: Human distal nephron and distal colon both exhibit mineralocorticoid sensitive electrogenic Na+ absorption and make significant contributions to Na+ homeostasis. Na+ resorption in the...
Constrictive pericarditis and intestinal haemorrhage due to Whipple's disease.
Crake, T., Sandle, G. I., Crisp, A. J., Record, C. O.
Two months after a pericardectomy for constrictive pericarditis a 37-year-old man presented with diarrhoea, abdominal pain and weight loss. During the course of investigation he developed brisk...