In situ product removal during enzymatic cephalexin synthesis by complexation (2002)
Nierstrasz, V.A., Bosma, R., Kemperman, G.J., Strubel, M., Ooijkaas, L.P., ...
In this paper, `complexation' indicates the formation of clathrate type inclusion compounds of cephalexin with naphthalene derivatives. These inclusion compounds readily crystallise in solution,...
In situ product removal during enzymatic cephalexin synthesis by complexation (2002)
Nierstrasz, V.A., Bosma, R., Kemperman, G.J., Strubel, M., Ooijkaas, L.P., ...
Complexants for the clathration mediated synthesis of the antibiotic cephradine (2001)
Kemperman, G.J., Dommerholt, F.J., Bosma, R., Zwanenburg, B.
Enzymatic synthesis of cephalosporins is hampered by secondary hydrolysis and by complicated down-stream processing. Instantaneous removal of cephalosporin product by clathration, using an efficient...