Rushbrook, S. M., Ward, S. M., Unitt, E., Vowler, S. L., Lucas, M., Klenerman, P., ...
The basis of chronic infection following exposure to hepatitis C virus (HCV) infection is unexplained. One factor may be the low frequency and immature phenotype of virus-specific CD8(+) T cells. The...
Neal, D.A.J., Brown, M.J., Wilkinson, I.B., Byrne, C.D., Alexander, G.J.M
Background: Hypertension is common after liver transplantation. There are few published data on optimum treatment. Augmentation index (AIx) is a measure of arterial wave reflection determined by...
Neal, D.A.J., Tom, B.D.M., Luan, J., Wareham, N.J., Gimson, A.E.S., Delriviere, L.D., ...
Background: Hypertension and hypercholesterolemia are recognized complications of liver transplantation, but whether they contribute to the development of cardiovascular disease is uncertain. We...
Hepatitis C-associated glomerulonephritis--a novel therapeutic approach (2001)
Reed, M. J., Alexander, G. J. M., Thiru, S., Smith, K. G. C.
Catterall, A. P., King, R., Lau, J. Y. N., Daniels, H. M., Alexander, G. J. M., Murray-Lyon, I. M., ...
To determine whether a priming course of lymphoblastoid interferon-alpha (IFN-α) enhances the efficacy of subsequent IFN-α therapy in the treatment of chronic hepatitis B, a randomized trial was...
Immunology of hepatitis B virus infection (1990)
The hepatitis B virus (HBV) is believed widely to be non-cytopathic in its natural host, man, although this may not be true in animal models, for example the transgenic mouse where expression of...
CONTRASTS IN INTERLEUKIN-1 AND INTERLEUKIN-2 ACTIVITY IN ALCOHOLIC HEPATITIS AND CIRRHOSIS (1989)
BIRD, G. L. A., ARIA, KAYHAN NOURI, DANIELS, HELENA, ALEXANDER, G.J. M., WILLIAMS, ROGER
To investigate whether disordered immune function, as shown by abnormalities in lymphokine production, is present in alcoholic liver disease, interleukin-1 and interleukin-2 activity were assayed in...
BIRD, G. L. A., SMITH, HEATHER, PORTMANN, B., ALEXANDER, G. J. M., WILLIAMS, ROGER
Five chronic carriers of hepatitis B virus developed a fulminant hepatitis-like picture when immunosuppression or cytotoxic treatment, given for unrelated disorders, was withdrawn. Viral replication...
LOW DENSITY LYMPHOCYTES: THEIR RELATIONSHIP TO DISEASE ACTIVITY AND TO ANTIRHEUMATIC THERAPY (1984)
ALEXANDER, G. J. M., BACON, P. A., CAVALCANTI, F., BLAKE, D. R., HALL, N. D.
The acquisition of low density by lymphocytes is the earliest detectable marker of their activation and may be utilized for the separation and quantification of these cells. Low density lymphocytes...
BED REST, ACTIVITY AND THE INFLAMMATION OF RHEUMATOID ARTHRITIS (1983)
ALEXANDER, G. J. M., HORTAS, C., BACON, P. A.
Seventy-five patients with rheumatoid arthritis have been studied in order to assess the relative contributions of bed rest and planned activity on the observed improvement in arthritis during...
Tacrolimus/cerivastatin interaction study in liver transplant recipients
Mück, W, Neal, D A J, Boix, O, Voith, B, Hasan, R, Alexander, G J M
WONG, V S, EGNER, W, ELSEY, T, BROWN, D, ALEXANDER, G J M
Hepatitis C virus (HCV) infection has been implicated in the pathogenesis of mixed cryoglobulinaemia. Several studies have shown the presence of anti-HCV antibodies and HCV-RNA in both sera and...