G. J. Peters

Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer (2009)

Sigmond, J., Honeywell, R. J., Postma, T. J., Dirven, C. M. F., De Lange, S. M., ...

Glioblastoma multiforme (GBM), the most frequent malignant brain tumor, has a poor prognosis, but is relatively sensitive to radiation. Both gemcitabine and its metabolite difluorodeoxyuridine (dFdU)...

DNA copy number profiles of primary tumors as predictors of response to chemotherapy in advanced colorectal cancer (2009)

Postma, C., Koopman, M., Buffart, T. E., Eijk, P. P., Carvalho, B., Peters, G. J., ...

Background: Colorectal cancer (CRC) is biologically a heterogeneous disease, which may affect response to drug therapy. We investigated the correlation of genome-wide DNA copy number profiles of...

[(18)F]FDG and [(18)F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study (2008)

Berndsen, S C, Proost, N, Peters, G J, Spreeuwenberg, M D, ...

Increased 2'-deoxy-2'-[(18)F]fluoro-D-glucose (FDG) uptake is the most commonly used marker for positron emission tomography in oncology. However, a proliferation tracer such as...

Antitumor activity and biodistribution of cisplatin nanocapsules in nude mice bearing human ovarian carcinoma xenografts (2008)

Born, Kasper Van Der, Erkelens, C.A.M., Hamelers, I.H.L., Peters, G.J., Boven, E., ...

Cisplatin nanocapsules represent a novel lipid formulation of the anticancer drug cis-diamminedichloridoplatinum(II) (cisplatin), characterized by an unprecedented cisplatin-tolipid molar ratio, and...

Inter-Division IV-V / Working Group Active B-type Stars: Triennial report 2006 - 2009 (2008)

Fabregat, J., Peters, G.J., Owocki, S.P., Bjorkman, K.S., Gies, D.R., Henrichs, H.F., ...

Magnetic fields in massive stars (2007)

Hubrig, S., Schoeller, M., Briquet, M., Pogodin, M. A., Yudin, R. V., Gonzalez, J. F., ...

We review the recent discoveries of magnetic fields in different types of massive stars and briefly discuss strategies for spectropolarimetric observations to be carried out in the future.

Evidence for weak magnetic fields in early-type emission stars (2007)

Hubrig, S., Yudin, R. V., Pogodin, M., Schoeller, M., Peters, G. J.

We report the results of our study of magnetic fields in a sample of 15 Be stars using spectropolarimetric data obtained at the European Southern Observatory with the multi-mode instrument FORS1...

Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation (2006)

Sigmond, J., Haveman, J., Castro Kreder, N., Loves, W.J., Bree, C. Van, Franken, N.A.P., ...

Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by gamma-irradiation (2006)

Haveman, J., Sigmond, J., Bree, C. Van, Franken, N.A.P., Koedooder, C., Peters, G.J.

Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase (2006)

Smorenburg, C. H., Peters, G. J., Van Groeningen, C. J., Noordhuis, P., Smid, K., ...

Background: Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are essential enzymes for 5-fluorouracil (5-FU) metabolism. In patients with advanced colorectal cancer (ACRC),...

Schedule dependent pharmacodynamice effects of gemcitabine and cisplatin in mice bearing Lewis lung murine non-small lung tumours (2005)

Kroep, J.R., Smid, K., Comijn, E.M., Voorn, D.A., Veerman, G., ...

Quantitative immunohistochemistry of dendritic cells in lymph nodes: a methodological study (2005)

Mauritz, R., Peters, G.J., Priest, D.G., Assaraf, Y.G., Drori, S., Kathman, L., ...

Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression after administration of 5-fluorouracil to patients with colorectal cancer (2005)

Mauritz, R., Groeningen, C.J. Van, Smid, K., Jansen, G., Pinedo, H.M., Peters, G.J.

Development of leucovorin/5-fluorouracil combinations (2005)

Peters, G.J., Groeningen, C.J. Van, Nadal, J.C., Lauresse, E., Pinedo, H.M.

Deoxycitidine kinase activity,protein and mRNA expressions are related to in vivo gemcitabine sensitivity: A possible role for clinical studies? (2005)

Kroep, J.R., Loves, W.J.P., Alvare, E., Talianidis, I., Groeningen, C.J. Van, ...

Pharmacokinetics of bolus 5-fluorouracil: relationship between dose, plasma concentrations, area-under-the-curve and toxicity (2005)

Codacci-Pisanelli, G., Pinedo, H.M., Lankelma, J., Groeningen, C.J. Van, Gennip, A.H. Van, ...

Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia (2005)

Jonge, R. De, Peters, G.J, Hooijberg, J.H., Zelst, B.D. Van, Jansen, G., Zantwijk, C.H. Van, ...

We studied whether common polymorphisms in genes involved in folate metabolism affect methotrexate (MTX) sensitivity. Ex vivo MTX sensitivity of lymphoblasts obtained from pediatric patients with...

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients (2005)

Westra, J. L., Hollema, H., Schaapveld, M., Platteel, I., Oien, K. A., Keith, W. N., ...

Background: The predictive value of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression on long-term survival by influencing 5-fluorouracil (5-FU) effect were determined in...

Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients (2005)

Westra, J. L., Hollema, H., Schaapveld, M., Platteel, I., Oien, K. A., Keith, W. N., ...

Background: The predictive value of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) expression on long-term survival by influencing 5-fluorouracil (5-FU) effect were determined in...

Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase (2005)

Smorenburg, C. H., Peters, G. J., Van Groeningen, C. J., Noordhuis, P., Smid, K., ...

Background: Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are essential enzymes for 5-fluorouracil (5-FU) metabolism. In patients with advanced colorectal cancer (ACRC),...

The effect of fluoropyrimidines with or without thymidine phosphorylase inhibitor in expression of thymidine phosphorylase (2004)

Bruin, M. De, Capel, T. Van, Smid, K., Fukushima, M., Hoekman, K., Pinedo, H.M., ...

Sulphasalazine down-regulates the expression of the angiogenic factors platelet derived endothelial cell growth factor / thymidine phosphorylase and interleukin 8 in human monocytic-macrophage THP-1 and U937 cells (2004)

Bruin, M. De, Peters, G.J., Oerlemans, R., Assaraf, Y.G., Masterson, A.J., Adema, A.D., ...

Phase II trial of cisplatin and gemcitabine in patients with advanced gas cancer (2004)

Lange, S.M. De, Groeningen, C.J. Van, Kroep, J.R., Bochove, A. Van, Snijders, J.F., Peters, G.J., ...

Phase II study of Cisplatin preceding gemcitabine in patients with advanced esophagel cancer (2004)

Kroep, J.R., Pinedo, H.M., Giaccone, G., Bochove, A. Van, Peters, G.J., Groeningen, C.J. Van

Cancer of the esophagus and gastric cardia: recent advances (2004)

Tytgat, G.N.J., Bartelink, H., Bernards, R., Giaccone, G., Offerhaus, G.J.A., ...

Purine and pyrimidine metabolism: new challenges (2004)

Peters, G.J., Abreu, R.A. De

Cellular response of X-ray sensitive hamster mutant cell lines to gemcitabine, cisplatin and 5-fluorouracil (2004)

Haveman, J., Castro Kreder, N., Rozermond, H.M., Bree, C. Van, Franken, N.A.P., Stalpers, L.J.A., ...

Cancer of the esophagus and gastric cardia: recent advances (2004)

Tytgat, G.N.J., Bartelink, H., Bernards, R., Giaccone, G., Offerhaus, G.J.A., ...

Cancer of the esophagus and gastric cardia: recent advances (2004)

Tytgat, G.N., Bartelink, H., Bernards, R.A., Giacone, G., Lanschot, J.J. Van, Offerhaus, G.J., ...

Esophageal cancer and cancer of the gastric cardia, in particular adenocarcinomas, have shown a rapid and largely unexplained increase in incidence in many developed countries around the world. These...

Combination therapy with gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, gemcitabine and cisplatin in patients with advanced solid tumors (2004)

Giaccone, G., González-Larriba, J. L., Van Oosterom, A. T., Alfonso, R., Smit, E. F., Martens, M., ...

Background: The aim of this study was to investigate the tolerability, pharmacokinetic interaction and antitumor activity of gefitinib (‘Iressa’, ZD1839), an orally active, selective epidermal...

Phase II study of cisplatin preceding gemcitabine in patients with advanced oesophageal cancer (2004)

Kroep, J. R., Pinedo, H. M., Giaccone, G., Van Bochove, A., Peters, G. J., Van Groeningen, C. J.

Background: For oesophageal cancer there is no effective standard therapy. We studied the feasibility and efficacy of the cisplatin–gemcitabine combination chemotherapy in patients with...

Phase II trial of cisplatin and gemcitabine in patients with advanced gastric cancer (2004)

De Lange, S. M., Van Groeningen, C. J., Kroep, J. R., Van Bochove, A., Snijders, J. F., Peters, G. J., ...

Background: This phase II study was performed to determine the efficacy and toxicity of cisplatin and gemcitabine in patients with advanced gastric cancer. Patients and methods: Forty chemo-naïve...

5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers (2004)

Noordhuis, P., Holwerda, U., Van Der Wilt, C. L., Van Groeningen, C. J., Smid, K., Meijer, S., ...

Background: The mechanism of action of 5-fluorouracil (5-FU) has been associated with inhibition of thymidylate synthase (TS) and incorporation of 5-FU into RNA and DNA, but limited data are...

Mass and Angular Momentum Transfer in the Massive Algol Binary RY Persei (2003)

Barai, P., Gies, D. R., Choi, E., Das, V., Deo, R., Huang, W., ...

We present an investigation of H-alpha emission line variations observed in the massive Algol binary, RY Per. We give new radial velocity data for the secondary based upon our optical spectra and for...

Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1 : 0.4 : 1) in patients with solid tumors (2003)

Peters, G.J., Noordhuis, P., Schornagel, J.H., Gall, H., Turner, S.L., ...

Thymidylate synthase inhibition triggers apoptosis via caspase-8 and 9 in both wild-type and mutan p53 colon cancer cell lines (2003)

Backus, H.H.J., Wouters, D., Ferreira, C.G., Brakenhoff, R., Pinedo, H.M., ...

Increased sensitivity to gemcitabine of P-glycoprotein and multi-drug resistance associated protein overexpressing human cancer cell lines (2003)

Bergman, A.M., Pinedo, H.M., Talianidis, I., Veerman, G., Loves, W.J.P., ...

Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensivity (2003)

Bruin, M. De, Capel, T. Van, Born, K. Van Der, Kruyt, F.A., Fukushima, M., Hoekman, K., ...

Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorlyse overexpressing cells (2003)

Bruin, M. De, Smid, K., Laan, A.C., Noordhuis, P., Fukushima, M., Hoekman, K., ...

Positron emission tomography using 2-deoxy-2 -fluoro-D-glucose for response monitoring in locally advanced gastroesophageal cancer (2003)

Kroep, J.R., Groeningen, C.J. Van, Cuesta, M.A., Craanen, M.E., Hoekstra, O.S., Comans, E.F., ...

Pharmacokineticss of S-1, an oral formulation off Ftoraffur,, oxonic acid and 5-chloro-2,44-dihhydroxypyridine in patientss with solid tumors (2003)

Peters, G.J., Noordhuis, P., Schornagel, J.H., Gall, H., Turner, S.L., ...

Effects of gemcitabine cisplatinum combinations on ribonucleotide and deoxyribonucleotide pools in ovarian cancer cell lines (2003)

Voorn, D.A., Smid, K., Bergman, A.M., Pinedo, H.M., Peters, G.J.

Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensivity and potential role of deoxyribose-1-phosphate (2003)

Bruin, M. De, Capel, T. Van, Born, K. Van Der, Kruyt, F.A., Fukushima, M., Hoekman, K., ...

Role of 5-fluorouracil incorporation into RNA and DNA of murine and human cancers (2003)

Noordhuis, P., Holwerda, U., Meijer, S., Groeningen, C.J. Van, ...

Role of Platelets derived Endothelial cell growth factor/Thymidine Phosphorylase in Fluoropyrimidine Sensitivity and Potential Role of Deoxyrobose-1-Phosphate (2003)

Bruin, M. De, Capel, T. Van, Smid, K., Born, K. Van Der, Fukushima, M., Hoekman, K., ...

Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia (2003)

Stam, R.W., Boer, M.L. Den, Meijerink, J.P., Ebus, M.E., Peters, G.J., Noordhuis, P., ...

Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of mixed lineage leukemia (MLL) gene rearrangements, a poor outcome, and resistance to chemotherapeutic drugs. One...

Enhanced levels of deoxycytidine kinase and thymidine kinase 1 and 2 after pulsed low dose rate irradiation as an adaptive response to radiation (2002)

Castro Kreder, N., Bree, C. Van, Peters, G.J., Loves, W.J., Haveman, J.

Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines (2002)

Bree, C. Van, Castro Kreder, N., Loves, W.J., Franken, N.A.P., Peters, G.J., Haveman, J.

Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases (2002)

Backus, H.H.J., Groeningen, C.J. Van, Vos, W., Dukers, D.F., Bloemena, E., Wouters, D., ...

Role of P53 status on sensitivity to Thymidylate synthase inhibitors and induction of apoptosis (2002)

Backus, H.H.J., Pinedo, H.M., Wouters, D., Koudijs, M., Ferreira, C.G., Peters, G.J.

Determinants of resistance tot 2',2'-difluorodeoxycytidine (gemcitabine) (2002)

Bergman, A.M., Pinedo, H.M., Peters, G.J.

High-dose 5-fluorouacil with uridine-disphoglucose rescue increases thymidylate synthase inhibition but no 5-fluorouracil incorporation into RNA in murine tumors (2002)

Codacci-Pisanelli, G., Smid, K., Noordhuis, P., Voorn, D., Pinedo, H.M., ...

Gemcitabine Radiotherapy in patients with Locally Advanced Pancreatic Cancer (2002)

Lange, S.M. De, Groeningen, C.J. Van, Meijer, O.W.M., Cuesta, M.A., Langendijk, J.A., ...

Pretreatment Deoxycytidine Kinase Levels Predict in Vivo Gemcitabine Sensitivity (2002)

Kroep, J.R., Loves, W.J.P., Alvarez, E., Talianidis, I., Boven, E., ...

Dose finding and pharmacokinetic study of cisplatin, gemcitabineand SU5426 in patients with solid tumors (2002)

Kuenen, B.C., Rosen, L., Smit, E.F., Parson, M.R.N., Ruyter, R., Huisman, H., ...

Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis (2002)

Mauritz, R., Peters, G.J., Priest, D.G., Assaraf, Y.G., Drori, S., Kathman, I., ...

Fluorouracil induced Fas and Apoptosis in liver metastases of colorectal cancer patientsss (2002)

Peters, G.J., Backus, H.H.J., Dukers, D.F., Groeningen, C.J. Van, Voss, W., Bloemena, E., ...

Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism (2002)

Peters, G.J., Backus, H.H.J., Freemantle, S., Triest, B. Van, Codacci-Pisanelli, G., ...

Kinetics of reduced folate carrier- and membrane-associated folate receptor-mediated transport of antifolates (2002)

Mauritz, R., Peters, G.J., Kathmann, G.A.M., Rosowsky, A., Pinedo, H.M., Jansen, G.

5-Fluorouracil induction of FAS and Apoptosis in colon cancer patients: relation of clinical outcome with thymidylate synthase, MCL-1 and RB (2002)

Peters, G.J., Backus, H.J.J, Dukers, D.F., Groeningen, C.J. Van, Vos, W., Bloemena, W., ...

Irinotecan and oxaliplatin: an overview of the novel chemotherapeutic options for the treatment of advanced colorectal cancer (2001)

Grivicich,I., Mans,D.R.A., Peters,G.J., Schwartsmann,G.

Colorectal cancer is one of the most frequent malignancies in humans and an important cause of cancer death. Metastatic colorectal cancer remains incurable with available systemic therapeutic...

Simultaneous determination of F-beta-alanine and beta-alanine in plasma and urine with dual-column reversed-phase high-performance liquid chromatography (2001)

Stroomer, A.E.M., Peters, G.J., Gennip, A.H. Van

Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer (2001)

Backus, H.H.J., Groeningen, C.J. Van, Vos, W., Dukers, D.F., Bloemena, E., ...

5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients (2001)

Backus, H.H.J., Dukers, D.F., Vos, W., Bloemena, E., Wouters, D., ...

Collateral sensitivity to gemcitabine (2',2'- difluorodeoxycytdine) and cytosine arabinoside of multidrug resistant variants of human small cell cancer cell lines (2001)

Bergman, A.M., Munch-Petersen, B., Jensen, P.B., Sehested, M., Veerman, G., Voorn, D.A., ...

Steroids affect collateral sensitivity to gemcitabine of multi- drug resistant human lung cancer cells (2001)

Bergman, A.M., Pinedo, H.M., Peters, G.J.

5-Fluorouracil induced Fas upregulation associated with apoptosis in liver metastases of colorectal cancer patients (2001)

Backus, H. H. J., Dukers, D. F., Van Groeningen, C. J., Vos, W., Bloemena, E., Wouters, D., ...

Background: In vitro, thymidylate synthase (TS) inhibition by 5-fluorouracil (5-FU) induces thymineless apoptosis possibly via Fas receptor–Fas ligand interactions and cell-cycle arrest. In...

Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer (2001)

Backus, H. H. J., Van Groeningen, C. J., Vos, W., Dukers, D. F., Bloemena, E., ...

Background: Thymidylate synthase (TS) has been associated with clinical outcome in disseminated colorectal cancer. However, many patients with lowTS expression still fail to respond to treatment....

Differences in the induction of DNA damage, cell cycle arrest and cell death by 5-fluorouracil and antifolates (2000)

Backus, H.H.J., Pinedo, H.M., Wouters, D., Kuiper, C.M., Jansen, G., Groeningen, C.J. Van, ...

Thymidylate synthase inhibition induces p53 dependent and independent cell death (2000)

Backus, H.H.J., Wouters, D., Kuiper, C.M., Groeningen, C.J. Van, Pinedo, H.M., ...

Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates (2000)

Backus, H.H.J., Pinedo, H.M., Wouters, D., Padron, J.M., Molders, N., ...

Cross-resistance in the 2', 2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs (2000)

Bergman, A.M., Giaccone, G., Mauritz, R., Noordhuis, P., Pinedo, H.M., ...

Drug-induced apoptosis in lung cancer cells is not mediated by the Fas/FasL (CD95/APO1) signallingpathway (2000)

Ferreira, C., Tolis, C., Span, S., Peters, G.J., Kummer, A.J., Pinedo, H.M., ...

Sequence dependent effect of paclitaxel on gemcitabine metabolism inrelation to cell cycle and cytotoxicity in non-small cell lung cancer cell lines (2000)

Kroep, J.R., Giaccone, G., Tolis, C., Voorn, D.A., Loves, W.J.P., Groeningen, C.J. Van, ...

Molecular downstream events and induction of thymidylate synthase in mutant and wild-type p53 colon cancer cell lines after treatment with 5-fluorouracil and the thymidylate synthase inhibitor Raltitrexed (2000)

Peters, G.J., Triest, G. Van, Backus, H.H.J., Kuiper, C.M., Pinedo, H.M.

Thymidine phosphorylase in angiogenesis and drug resistance Homology with platelet- derived endothelial cell growth factor (2000)

Peters, G.J., Bruin, M. De, Fukushima, M., Triest, B. Van, Hoekman, K., Pinedo, H.M., ...

The role of deoxycytidine kinase in gemcitabine cytotoxicity. (2000)

Kroep, J.R., Bergman, A.M., Loves, W.J.P., Alvarez, E., Talianidis, I., ...

Phase I clinical and pharmacokinetic study of oral S-1 in patients with advanced solid tumors (2000)

Groeningen, C.J. Van, Peters, G.J., Schornagel, J.H., Gall, H., Noordhuis, P., Vries, M.J. De, ...

Schedule-dependent pharmacodynamic effects of gemcitabine and cisplatin in mice bearing Lewis lung murine non-small cell lung tumours (2000)

Pinedo, H.M., Smid, K., Comijn, E.M., Voorn, D.A., Veerman, G., ...

Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukemia cell lines (2000)

Bergman, A.M., Veerman, G., Voorn, D.A., Kroep, J.R., ...

Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and profileration markers in colorectal cancer (2000)

Triest, B. Van, Pinedo, H.M., Blauwgeers, J.L.G., Diest, P.J. Van, Schoenmakers, P.S., Voorn, D.A., ...

Downstream molecular determinants of response to 5-fluorouacil and antifolate thymidylate synthase inhibitors (2000)

Triest, B. Van, Pinedo, H.M., Giaccone, G., Peters, G.J.

Thymidylate syntase expression in patients with colorectal carcinoma using a polyclonal thymidylate syntase antibody in comparison to the TS106 monoclonal antibody. Journal of Histochem (2000)

Triest, B. Van, Loftus, B.M., Pinedo, H.M., Backus, H.H.J., Schoenmakers, P., Telleman, F., ...

The role of deoxycytidine kinase in gemcitabine cytotoxicity (2000)

Kroep, J.r., Bergman, A.M., Loves, W.J.P., Alvarez, E., Talianidis, I., ...

Thymidine phosphorylase in angiogenesis and drug resistance. Homology with platelet-derived endothelial cell growth factor (2000)

Pinedo, H.M., Peters, G.J., Bruin, M. De, Fukushima, M., Triest, B. Van, Hoekman, K., ...

Thymidylate synthase (TS) inhibition induces p53 dependent and independent cell death (2000)

Backus, H.H.J., Wouters, D., Kuiper, C.M., Groeningen, C.J. Van, Pinedo, H.M., ...

Dose finding study of cisplatin, gemcitabine and SU-5416 in patients with advanced malignancies (2000)

Giaccone, G., Rosen, L., Kuenen, B., Ruijter, R., Peters, G.J., ...

Thymidilate Synthase (TS), p53 and Rb are related to survival in colorectalcancer patients with liver metastases (2000)

Backus, H.H.J., Vos, W., Bloemena, E., Dukers, D.F., Wouters, D., ...

The role of platelet derived endothelial cell growth factor/thymidine phosphorylase (PD-ECGF/TP) in prodrug activation in colon cancer cell lines (2000)

Bruin, M. De, Peters, G.J., Hoekman, K., Pinedo, H.M.

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors (2000)

Van Triest, B., Pinedo, H. M., Giaccone, G., Peters, G. J.

Thymidylate synthase (TS) is an essential enzyme for the de novo synthesis of thymidylate and subsequently DNA synthesis. TS has been used as a target for cancer chemotherapy in the development of...

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2 (1999)

Hooijberg, J.H., Broxterman, H.J., Kool, M., Assaraf, Y.G., Peters, G.J., Noordhuis, P., ...

MRP3, an organic anion transporter able to transport anti-cancer drugs (1999)

Kool, M., Linden, M. Van Der, Haas, M. De, Scheffer, G.L., Smith, A.J., ...

Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinosideresistant myeloblastic murine and rat leukemia cell lines: Role of altered activity and substrate specificity of deoxycytidine kinase (1999)

Bergman, A.M., Pinedo, H.M., Jongsma, A.P.M., Brouwer, M., Veerman, G., ...

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2 (1999)

Hooijberg, J.H., Broxterman, H.J., Kool, M., Assaraf, Y.G., Peters, G.J., Noordhuis, P., ...

Folypolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo (1999)

Jansen, G., Peters, G.J., Pinedo, H.M., Priest, D.G., Assaraf, Y.G.

Gemcitabine and paclitaxel (1999)

Kroep, J.R., Giaccone, G., Voorn, D.A., Smit, E., Beijnen, J.H., Rosing, H., ...

Gemcitabine-cisplatin : a schedule finding study (1999)

Kroep, J.R., Peters, G.J., Catik, A., Vermorken, J.B., Pinedo, H.M., ...

Experimental drugs and drug combinations in pancreatic cancer (1999)

Kroep, J.R., Pinedo, H.M., Groeningen, C.J. Van, Peters, G.J.

Determinants of activity of the antifolate thymidylate synthase inhibitors Tomudex (ZD 1694) and GW 1843U89 against mono- and multilayered colon cancer cell lines under folate-restricted conditions (1999)

Peters, G.J., Smitskamp-Wilms, E., Smid, K., Pinedo, H.M., Jansen, G.

Differential effects of gemcitabine on ribonucleotide pools of twenty-one solid tumour and leukemia cell lines (1999)

Bergman, A.M., Veerman, G., Voorn, D.A., Kroep, J.R., ...

Scheduling of gemcitabine and cisplatin in Lewis Lung tumour bearing mice (1999)

Pinedo, H.M., Veerman, G., Vermorken, J.B., Postmus, P.E., Peters, G.J.

Combination chemotherapeutic studies with gemcitabine and etoposide in non-small cell lung and ovarian cancer cell lines (1999)

Pinedo, H.M., Veerman, G., Guechev, A., Smid, K., Loves, W.J.R., ...

Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors (1999)

Kroep, J.R., Pinedo, H.M., Veerman, G., Voorn, D.A., Postmus, P.E., ...

Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small cell lung cancer cell lines (1999)

Pinedo, H.M., Veerman, G., Bergman, A.M., Vermorken, J.B., ...

Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines (1999)

Tolis, C., Peters, G.J., Ferreira, C.G., Pinedo, H.M., Giaccone, G.

Thymidylate synthase levels as main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors in 13 non-selected colon cancer cell lines (1999)

Triest, B. Van, Pinedo, H.M., Hensbergen, Y. Van, Smid, K., Telleman, F., Schoenmakers, P.S., ...

Gemcitabine-cisplatin: a schedule finding study (1999)

Peters, G.J., Pinedo, H.M.

Experimental drugs and drug combinations in pancreatic cancer (1999)

Kroep, J.R., Pinedo, H.M., Groeningen, C.J. Van, Peters, G.J.

Biological activity of 1-deazapurine nucleosides: role of deoxycytidine kinase? (1999)

Pinedo, H.M., Bergman, A.M., Cristalli, G., Vittori, S., Wang, J., Eriksson, S., ...

Cell specific cytotoxity and structure-activity relationship of lipohilic 1-ß-D-arabinofuranosylcytosine (ara-C) derivates (1999)

Pinedo, H.M., Peters, G.J., Voorn, D.A., Kuiper, C.M., Noordhuis, P., ...

Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors (1999)

Kroep, J.R., Pinedo, H.M., Veerman, G., Voorn, D.A., Postmus, P.E., ...

Purpose: To determine possible schedule dependent pharmacokinetic and pharmacodynamic interactions between gemcitabine (2',2'-difluorodeoxycytidine, dFdC) and cisplatin...

Gemcitabine-cisplatin: A schedule finding study (1999)

Kroep, J. R., Peters, G. J., Çatik, A., Vermorken, J. B., Pinedo, H. M., ...

Purpose: To evaluate the tolerability of four alternating cisplatin–gemcitabine schedules. A secondary aim was to evaluate the clinical efficacy of this combination. Patients and methods: Forty-one...

Experimental drugs and drug combinations in pancreatic cancer (1999)

Kroep, J.R., Pinedo, H.M., Van Groeningen, C.J., Peters, G.J.

The current role of chemotherapy in pancreatic cancer is limited. Chemotherapy usually consists of 5-fluorouracil (5FU) and gemcitabine either as a single agent or in combinations. However, response...

No circadian variation of dihydropyrimidine dehydrogenase uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-fluorouracil (1998)

Poorter, R.L., Peters, G.J., Gennip, A.H. Van, Lenthe, H. Van, Stroomer, A.E.M., ...

No circadian variation of dihydropyrimidine dehydrogenase, uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-fluorouracil (1998)

Poorter, R.L., Peters, G.J., Gennip, A.H. Van, Lenthe, H. Van, Stroomer, A.E.M., ...

No circadian variation of dihydropyrimidine dehydrogenase, uridine phosphorylase, beta-alanine, and 5-fluorouracil during continuous infusion of 5-flurouracil (1998)

Poorter, R.L., Peters, G.J., Gennip, A.H. Van, Lenthe, H. Van, Stroomer, A.E.M., ...

A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance (1998)

Jansen, G., Mauritz, R., Drori, S., Sprecher, H., Kathmann, I., Bunni, M., ...

Ex vivo activity of methotrexate versus novel antifolate inhibitors of dihydrofolate reductase and thymidylate synthase against childhood leukemia blast cells (1998)

Mauritz, R., Bekkenk, M., Rots, M.G., Pieters, R., Mini, E., Veerman, A.J.P., ...

Postconfluent multilayered cell line cultures for selective screening of Gemcitabine (1998)

Smitskamp-Wilms, E., Pinedo, H.M., Veerman, G., Peters, G.J.

Dihydropyrimidine dehydrogenase in livers from mouse and rat, and in human liver, colon tumors, and mucosa in relation to anabolism of 5-fluoracil (1998)

Peters, G.J., Groeningen, C.J. Van, Pinedo, H.M.

Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines (1998)

Bergman, A.M., Pinedo, H.M., Veerman, G., Kuiper, C.M., Peters, G.J.

Cross resistance of the gemcitabine resistant human ovarian cancer cell line AG6000 to standard and investigational drugs (1998)

Bergman, A.M., Pinedo, H.M., Ruiz Van Haperen, V.W., Veerman, G., Kuiper, C.M., Peters, G.J.

Increased sensitivity to gemcitabine of P-gP and MRP overexpressing human non-small cell lung cancer cell lines (1998)

Bergman, A.M., Pinedo, H.M., Veerman, G., Kuiper, C.M., Peters, G.J.

Mechanisms of synergism between gemcitabine and cisplatin (1998)

Peters, G.J., Kuiper, C.M., Triest, B. Van, Backus, H., Laar, J.A. Van, ...

Determinants of the therapeutic efficacy of thymidylate synthase inhibitors (1998)

Peters, G.J., Kuiper, C.M., Triest, B. Van, Backus, H., Laar, J.A. Van, ...

Role of deoxycytadine kinase (dCK), thymidine kinase 2 (TK2), and deoxycytadine deaminase (dCDA) in antitumor activity of gemcitabine (dFdC) (1998)

Kroep, J.R., Moorsel, C.J. Van, Veerman, G., Voorn, D.A., Schultz, R.M., Worzalla, J.F., ...

Toxicity Profiles In Vivo in Mice and Antitumour Activity in Tumour-Bearing Mice of Di- and Triorganotin Compounds (1998)

M. Gielen, R. Willem, H. Dalil, D. De Vos, C. M. Kuiper, G. J. Peters

The in vivo toxicity profiles in mice and the antitumour activity in tumour bearing mice were screened for four di-n-butyltin and five triorganotin carboxylates, di-n-butyltin diterebate (5),...

Gemcitabine: Future Prospects of Single-Agent and Combination Studies (1997)

Peters, G.J., Pinedo, H.M.

Regulation of carrier mediated transport of folates and antifolates in methotrexate sensitive and resistant cell lines (1997)

Jansen, G., Mauritz, R., Assaraf, Y.G., Sprecher, H., Drori, S., Kathman, I., ...

5-Flourouracil - Leucovorin induced inhibition of thymidylate synthase in normal tissues of mouse and man (1997)

Groeningen, C.J. Van, Pinedo, H.M., Smid, K., Hoekman, K., Meijer, S., ...

Determinants of the therapeutic efficady of thymidylate synthase inhibitors (1997)

Peters, G.J., Kuiper, C.M., Triest, B. Van, Jansen, G., ...

Dihydropyrimide dehydrogenase in livers from mouse and rat, and in human liver, colon tumors and mucosa in relation to anabolism of 5j-fluorouracil in colon cancer cell lines (1997)

Peters, G.J., Groeningen, C.J. Van, Pinedo, H.M.

A novel mechanism of antifolate resistance based on increased RFC-mediated folic acit transport in human CCRF-CEM leukemia cells (1997)

Jansen, G., Mauritz, R., Drori, S., Sprecher, H., Kathmann, I., Bunni, M., ...

A Multilayered Postconfluent Tumor Cell Culture System for In Vitro Drug Screening (1996)

Smitskamp-Wilms, E., Hendriks, H.R., Pizao, P.E., Giaccone, G., Pinedo, H.M., Peters, G.J.

Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphophate and uridine 5'-triphophate in relation to chemosensitivity for 2', 2'-difluorodeoxycytidine (1996)

Veerman, G., Vermorken, J.B., Pinedo, H.M., Peters, G.J.

Antitumor activity of prolonged as compared with bolus administration of 2',2'diflu -orodeoxycitidine in vivo against murine colon tumors (1996)

Veerman, G., Vermorken, J.B., Noordhuis, P., Braakhuis, B.J.M., Pinedo, H.M., ...

Tumor size and origin determine atitumor activity of cisplatin of 5-fluorouracil and its modulation by leucovorin in murine colon carcinomas (1996)

Rustum, Y.M., Smid, K., Kuiper, C.M., Pinedo, H.M., ...

Superior therapeutic acitivity of prolonged compared to bolus administration of 2',2'-difluorodeoxycytidine (gemcitabine) in vivo against murine colon tumors (1996)

Veerman, G., Vermorken, J.B., Pinedo, H.M., Peters, G.J.

Van de Velde, C.J.H., Peters, G.J. The effect of different routes of administration of 5-fluorouracil on thymidylate synthase inhibition in the rat (1995)

Marinelli, A., Pinedo, H.M., Cloos, J., Smid, K., ...

Antitumour activity, toxicity and inhibition of thymidylate syntahse of prolonged administration of 5-fluorouracil in mice (1995)

Codacci-Pisanelli, G., Pinedo, H.M., Franchi, F., Noordhuis, P., Braakhuis, B.J.M., ...

Three dimensional cell cultures as a model system to evaluate the biological activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine) (1995)

Peters, G.J., Smitskamp-Wilms, E., Veerman, G., Pizao, P.E., Pinedo, H.M.

Thymidylate synthase and drug resistance (1995)

Peters, G.J., Triest, B. Van, Codacci-Pisanelli, G., Johnston, P.G., Groeningen, C.J. Van, ...

Quantification of 5-fluorouracil inccorporation into RNA of human and murine tumors as measured with a sensitive gaschromatography-mass spectrometry assay (1995)

Peters, G.J., Noordhuis, P., Komissarov, A., Holwerda, U., Kok, R.M., ...

DT-diaphorase activity in normal and neoplastic human tissues; and indicator for EO9 sensitivity? (1995)

Smitskamp-Wilms, E., Giaccone, G., Pinedo, H.M., Peters, G.J.

Cross resistance to thymidylate synthase inhibitors in p-glycoprotein and non-p-glycoprotein cell lines (1995)

Triest, B. Van, Telleman, F., Pinedo, H.M., Peters, G.J.

Functional activity of the reduced folate carrier in KB, MA104 and IGROV-I cells expressing folate-binding protein (1995)

Westerhof, G.R., Rijnboutt, S., Schornagel, J., Pinedo, H.M., Peters, G.J., Jansen, G.

Carrier and receptor mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity (1995)

Westerhof, G.R., Schornagel, J.H., Kathmann, G.A.M., Jackman, A.L., Rosowsky, A., Forsch, R.A., ...

The effect of different routes of administration of 5-fluorouracil on inhibition of thymidylate synthase in rat tissues (1995)

Marinelli, A., Pinedo, H.M., Cloos, J., Smid, K., ...

Screening of colon tumor cells and tissues for folypolyglutamate synthetase activity (1995)

Cloos, J., Jong, M. De, Pinedo, H.M., Peters, G.J.

The synergistic and antagonistic effects of cytotoxic and biological agents on the in vitro antitumour effect of suramin (1994)

Lopez Lopez, R., Wagstaff, J., Pinedo, H.M., Peters, G.J.

Effect of suramin on adenaylate cyclase and protein kinase C (1994)

Lopez Lopez, R., Langeveld, C.H.N., Pizao, P.E., Wagstaff, J., Pinedo, H.M., ...

In vitro sequence-dependent synergistic effect of suramin and captothecin (1994)

Lopez Lopez, R., Peters, G.J., Smitskamp-Wilms, E., Virizuela, J.A., Ark-Otte, J. Van, Pinedo, H.M., ...

Thymidylate synthase inhibition after administration of 5-fluorouracil with or without leucovorin; implications for treatment with 5-fluorouracil (1994)

Peters, G.J., Groeningen, C.J. Van, Meijer, S., Smid, K., Pinedo, H.M.

Development and molecular characterization of a 2'2'-difluorodeoxycytidine-resitant variant of the ovarian carcinoma cell line A2780 (1994)

Veerman, G., Eriksson, S., Boven, E., Stegmann, A.P.A., Hermsen, M., ...

Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression (1994)

Smitskamp-Wilms, E., Peters, G.J., Pinedo, H.M., Ark-Otte, J. Van, Giaccone, G.

Effects of the modulating agent WR 2721 on myelotoxicity and antiumour activity in carboplatin treated mice (1994)

Treskes, M., Boven, E., Cloos, J., Peters, G.J., ...

Antiproliferatieve activity of the topoisomerase I inhibitors topotecan and camptothecin, on sub- and postconfluent tumor cell cultures (1994)

Pizao, P.E., Smitskamp-Wilms, E., Ark-Otte, J. Van, Beijnen, J., Peters, G.J., Pinedo, H.M., ...

Reversal of 5-fluorouracil-induced toxicity by oral administration of uridine (1993)

Groeningen, C.J. Van, Peters, G.J., Pinedo, H.M., Pinedo, H.M.

Prelonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma (1993)

Peters, G.J., Lankelma, J., Kok, R.M., Noordhuis, P., Groeningen, C.J. Van, ...

Potentiation of 5-fluorouracil induced inhibition of thymidylate synthase in human colon tumors by leucovorin is dose dependent (1993)

Peters, G.J., Hoekman, K., Groeningen, C.J. Van, Smid, K., Meijer, S., ...

Transformation of mouse fibroblasts with the oncogenes H-ras or trk is associated with pronounced changes in drug sensitivity and metabolism (1993)

Peters, G.J., Wets, M., Oskam, R., Ark-Otte, J. Van, Noordhuis, P., ...

Development of a simple folylpolyglutamate synthase assay in tissues and cell lines (1993)

Peters, G.J., Cloos, J., Pinedo, H.M.

Development, characterization and application of an antibody against 5-fluoro-2'deoxy-5'monophosphate, the active metabolite of 5-fluorouracil (1993)

Peters, G.J., Laurensse, E.J., Steinbusch, H.W.M., Vente, J. De, Smid, K., ...

Cytotoxic effects of anticancer agents on subconfluent and multilayered postconfluent cultures (1993)

Pizao, P.E., Peters, G.J., Ark-Otte, J. Van, Smets, L.A., Smitskamp-Wilms, E., Winograd, B., ...

Evaluation of immunohistochemical staining and activity of thymidylate synthase in cell lines (1993)

Smid, K., Aherne, G.W., Pinedo, H.M., Peters, G.J.

The interval between methotrexate and leucovorin determines the efficacy of 5-flurorouracil modulation in vitro and in vivo (1993)

Jong, M. De, Braakhuis, B.J.M., Pinedo, H.M., Peters, G.J.

Effect of folate diastereoisomers on the binding of 5-fluoro-2'-deoxyuridine-5'-monophosphate to thymidylate synthase (1993)

Pinedo, H.M., Jong, M. De, Peters, G.J.

Novel approaches to selective treatments of human solid tumors: Laboratory and clinical correlation: international symposioum held at the Rosewell Park Cnacer Institute, Buffalo, N.Y, U.S.A., Sept. 1992 (organized by Dr.Y.M. Rustum) (1993)

Peters, G. J., Rustum, Y. M.

Reversal of 5-fluorouracil-induced toxicity by oral administration of uridine (1993)

Van Groeningen, C. J., Peters, G. J., Pinedo, H. M.

Background: Previous preclinical and clinical investigations have shown that the combined administration of 5-fluoro-uracil (5-FU) with delayed uridine can reverse side effects induced by 5-FU. This...

Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase (1992)

Pinedo, H.M., Smid, K., Cloos, J., Noordhuis, P., Peters, G.J.

Modulation of fluorouracil toxicity with uridine (1992)

Groeningen, C.J. Van, Peters, G.J., Pinedo, H.M.

Protection by WR-2721 of the toxicity induced by the combination of cisplatin and 5-fluorouraci (1992)

Peters, G.J., Gyergyay, F., Treskes, M., ...

The effect of schedule, protein binding and growth factors on the activity of suramin (1992)

Lopez Lopez, R., Peters, G.J., Loenen, A.C. Van, Pizao, P.E., Wagstaff, J., ...

In vitro and in vivo studies on the combination of brequinar sodium (Dup-785; NSC 368390) with 5-fluorouracil; effects of uridine (1992)

Peters, G.J., Kraal, I., Pinedo, H.M.

In vitro chemosensitivity testing of multilayered microcultures (1992)

Pizao, P.E., Winograd, B., Peters, G.J., Leyva, A., Giaccone, G., Pinedo, H.M.

Growth, morphology and chemosensitivity studies on postconfluent cells cultured in 'V'-bottomed microtiter plates (1992)

Pizao, P.E., Lyaruu, D.M., Peters, G.J., Ark-Otte, J. Van, Winograd, B., Giaccone, G., ...

Elevation of thymidylate synthase following 5-Fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors (1992)

Pinedo, H.M., Smid, K., Peters, G.J.

Effect of leucovorin on 5-fluorouracil induced inhibition of thymidylate synthase in patients with colon cancer. Purine and Pyrimidin Metabolism in Man VII (1991)

Peters, G.J., Groeningen, C.J. Van, Smid, K., Meijer, S., Pinedo, H.M.

Concentration and time dependent growth inhibition and metabolism in vitro by 2',2'-difluoro-deoxycytidine (Gemcitabine). Purine and Pyrimidine Metabolism in Man VII (1991)

Haperen, Ruiz Van, Veerman, V.W.T., Pinedo, H.M., Vermorken, J.B., Peters, G.J.

Isolated liver perfusion versus hepatic artery infusion with 5-fluorouracil in a rat model: Effects of thymidylate synthase (1991)

Marinelli, A., Cloos, J., Smid, K., Pinedo, H.M., Peters, G.J.

Clinical pharmacology study of orally administered uridine (1991)

Groeningen, C.J. Van, Peters, G.J., Nadal, J.C., Laurensse, E.J., Pinedo, H.M.

Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing (1991)

Keepers, Y.P., Pizao, P.E., Peters, G.J., Ark-Otte, J. Van, Winograd, B., Pinedo, H.M.

A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa (1991)

Peters, G.J., Groeningen, C.J. Van, Laurensse, E., Pinedo, H.M.

Measurement of in vitro cellular pharmacokinetics of 5-fluorouracil in human and rat cancer cell lines and rat hepatocytes using a flow-through system (1991)

Spoelstra, E.C., Pinedo, H.M., Dekker, H., Peters, G.J., Lankelma, J.

Do inhibitors of IMP dehydrogenase have a future in cancer chemotherapy? (1991)

Geijssen, G.J., Pieters, R., Veerman, A.J.P., Pinedo, H.M., Peters, G.J.

Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxyuridine-5'-monophosphate (1991)

Peters, G.J., Groeningen, C.J. Van, Laurensse, E., Pinedo, H.M.

Clinical and Pharmacologic Study of Orally Administrated Uridine (1991)

Van Groeningen, G. J., Peters, G.J., Nadal, J. C., Laurensse, E., Pinedo, H. M.

Effects of Oral administrations of uridine were investigated in a study of six healthy volunteer control subjects and nine patients with metastatic colorectal cancer. Oral uridine was studied as...

In vivo inhibition of the pyrimidine de novo enzyme dihydrorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients (1990)

Peters, G.J., Schwartsmann, G., Nadal, J.C., Laurensse, E.J., Groeningen, C.J. Van, Pinedo, H.M.

Do antimetabolites interfere with the glycosylation of cellular glycoconjugates (1990)

Peters, G.J., Pinedo, H.M., Ferwerda, W., Graaf, T.W. De, Dijk, W. Van

Retention of in vivo antipyrimidine effects of brequinar sodium (DUP-785;NSC 368390) in murine liver, bone marrow and colon cancer (1990)

Peters, G.J., Nadal, J.C., Laurensse, E., Kant, E. De, Pinedo, H.M.

Pyrimidine metabolism in murine colon cancer models; relevance for chemotherapy with antimetabolites (1990)

Peters, G.J., Smid, K., Veerman, G., Laurensse, E., ...

Reversal of 5-fluorouracil-induced myelosuppression by prolonged administration of high-dose uridine (1989)

Groeningen, C.J. Van, Peters, G.J., Leyva, A., Laurensse, E.J., Pinedo, H.M.

The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by brequinar sodium (1989)

Kant, E. De, Pinedo, H.M., Laurensse, E., Peters, G.J.

Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors (1989)

Laurensse, E., Braakhuis, B.J.M., Pinedo, H.M., Peters, G.J.

Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolic ezymes (1989)

Peters, G.J., Braakhuis, B.J.M., Bruyn, E.A. De, Laurensse, E.J., Walsum, M. Van, Pinedo, H.M.

The relationship between dihydroorotic acid dehydrogenase and in vitro and in vivo cytostatic effects of Brequinar (DUP-785; NSC 368390) (1989)

Peters, G.J., Laurensse, E., Kant, E. De, Nadal, J.C., Pinedo, H.M.

In vitro and in vivo inhibition of thymidylate synthase of human colon cancer by 5-fluorouracil (1989)

Peters, G.J., Laurensse, E., Groeningen, C.J. Van, Meijer, S., Pinedo, H.M.

Effect of leucovorin on 5-fluorouracil induced inhibition of thymidylate synthase in murine colon cancer (1989)

Peters, G.J., Pinedo, H.M.

Schedule-dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma (1989)

Nadal, J.C., Groeningen, C.J. Van, Pinedo, H.M., Peters, G.J.

Reversal of 5-Fluorouracil-Induced Myelosuppression by Prolonged Administration of High-Dose Uridine (1989)

Groeningen, C.J. Van, Peters, G.J., Leyva, A., Laurensse, E., Pinedo, H.M.

The effect of high-dose uridine on 5-fluorouracil (5-FU)-induced toxicity was investigated. Nine patients were treated weekly with 5-FU at increasing dosages. Five patients developed dose-limiting...

Pharmacokinetics of 5 fluorouracil assesses with a sensitive mass spectrometric method in patients on a dose escalation schedule (1988)

Groeningen, C.J. Van, Pinedo, H.M., Heddes, J., Kok, R.M., Wattel, E., ...

Peters, G.J. A sensitive nonradioactive assay for pyrimidine nucleoside phosphorylase using reverse phase high performance liquid chromatography (1988)

Laurensse, E., Pinedo, H.M., Peters, G.J.

In vivo potentiation of 5 fluorouracil by leucovorin in murine colon carcinoma (1988)

Nadal, J.C., Pinedo, H.M., Groeningen, C.J. Van, Peters, G.J.

5 Fluorouracil; biochemistry and pharmacology (1988)

Pinedo, H.M., Peters, G.J.

DUP 785 (NSC 368390): schedule-dependency of growth inhibitory and antipyrimidine effects (1988)

Schwartsmann, G., Peters, G.J., Laurensse, E., Waal, F.C. De, Loonen, A.H., Leyva, A., ...

In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5 fluorouracil (1988)

Peters, G.J., Dijk, J. Van, Laurensse, E., Groeningen, C.J. Van, Lankelma, J., Leyva, A., ...

A sensitive, non radiometric assay for dihyroorotic acid de hydrogenase using anion exchange high performance liquid chromatogra phy (1987)

Peters, G.J., Laurensse, E., Leyva, A., Pinedo, H.M.

Effect of pyrimidine nucleosides on body temperature of man and rabbit in relation to pharmacokinetic data (1987)

Peters, G.J., Groeningen, C.J. Van, Lauresse, E., Kraal, I., Leyva, A., Lankelma, J., ...

Uridine induced hypothermia in mice and rabbits in relation to plasma and tissue levels of uridine and its metabolites (1987)

Peters, G.J., Groeningen, C.J. Van, Lauresse, E., Lankelma, J., Pinedo, H.M.

Purine nucleosides as cell specific modulators of 5 fluoro uracil metabolism and cytotoxicity (1987)

Peters, G.J., Laurensse, E., Pinedo, H.M., Lankelma, J.

Inhibition of pyrimidine de novo synthesis by DUP 785 (NSC 368390) (1987)

Peters, G.J., Sharma, S.L., Laurensse, E., Pinedo, H.M.

Diurnal variation in the therapeutic efficacy of 5 fluorouracil against murine colon cancer (1987)

Peters, G.J., Dijk, J. Van, Nadal, J.C., Groeningen, C.J. Van, Lankelma, J., Pinedo, H.M.

Toxicity and antitumor effect of 5 fluorouracil and its rescue by uridine (1986)

Peters, G.J., Dijk, J. Van, Groeningen, C.J. Van, Laurensse, E.J., Leyva, A., Lankelma, J., ...

Modulation of cytotoxicity and metabolism of 5 fluorouracil in two intestine cell lines (1986)

Peters, G.J., Laurensse, E.J., Leyva, A., Pinedo, H.M.

Clinical and pharmacokinetic studies of prolonged administration of high dose uridine intended for rescue from 5 fluorouracil toxicity (1986)

Groeningen, C.J. Van, Leyva, A., Kraal, I., Peters, G.J., Pinedo, H.M.

Sensitivity of human, murine and rat cells to 5 fluorouracil and 5'deoxy 5 fluorouridine in relation to drug metabolizing enzymes (1986)

Peters, G.J., Laurensse, E., Leyva, A., Lankelma, J., Pinedo, H.M.

Tissue homogenization using a micro-dismembrator for the measurement of enzyme activities (1986)

Peters, G.J., Laurensse, E.J., Leyva, A., Pinedo, H.M.

The concentration of 5 phosphoribosyl l pyrophosphate in monolayer tumor cells and the effect of various pyrimidine (1985)

Peters, G.J., Laurensse, E., Leyva, A., Pinedo, H.M.

Separation of several 5 fluorouracil metabolites in various melanoma cell lines. Evidence for the synthesis of 5 fluorouraci lnucleotide sugars (1984)

Peters, G.J., Laurensse, E., Lankelma, J., Leyva, A., Pinedo, H.M.

Fluctuations in phosphoribosyl pyrophosphate levels in monolayer tumor cell lines (1984)

Peters, G.J., Lauresse, E., Leyva, A., Pinedo, H.M.

Separation of 5 fluorouracil and uracil by ion pair reversed phase high performance liquid chromatography on a column with porous polymer packing (1984)

Peters, G.J., Kraal, I., Lauresse, E., Leyva, A., Pinedo, H.M.

Pyrimidine Metabolism in Lymphocytes and Erythrocytes of Man, Horse and Cattle (1979)

Veerkamp, J. H., Peters, G. J., Tax, W. J. M.

Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases

Backus, H H J, Van Groeningen, C J, Vos, W, Dukers, D F, Bloemena, E, Wouters, D, ...

Aims: Tumour cell growth results from a disturbance in the balance between the rate of proliferation and cell death. In this study, proteins involved in the regulation of cell cycle arrest and...

Toxicity Profiles In Vivo in Mice and Antitumour Activity in Tumour-Bearing Mice of Di- and Triorganotin Compounds

Gielen, M., Willem, R., Dalil, H., De Vos, D., Kuiper, C. M., Peters, G. J.

The in vivo toxicity profiles in mice and the antitumour activity in tumour bearing mice were screened for four di-n-butyltin and five triorganotin carboxylates, di-n-butyltin diterebate (5),...

Immunocytochemical detection of deoxycytidine kinase in haematological malignancies and solid tumours

Hubeek, I, Peters, G J, Broekhuizen, A J F, Talianidis, I, Sigmond, J, Gibson, B E S, ...

Background: Deoxycytidine kinase (dCK) is responsible for the activation of several clinically important deoxynucleoside analogues used for the treatment of haematological and solid malignancies.

[18F]FDG and [18F]FLT uptake in human breast cancer cells in relation to the effects of chemotherapy: an in vitro study

Direcks, W G E, Berndsen, S C, Proost, N, Peters, G J, Balzarini, J, Spreeuwenberg, M D, ...

Increased 2′-deoxy-2′-[18F]fluoro-D-glucose (FDG) uptake is the most commonly used marker for positron emission tomography in oncology. However, a proliferation tracer such as...

Molecular pathways involved in the synergistic interaction of the PKCβ inhibitor enzastaurin with the antifolate pemetrexed in non-small cell lung cancer cells

Tekle, C, Giovannetti, E, Sigmond, J, Graff, J R, Smid, K, Peters, G J

Conventional regimens have limited impact against non-small cell lung cancer (NSCLC). Current research is focusing on multiple pathways as potential targets, and this study investigated molecular...

In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis.

Van Der Wilt, C. L., Visser, G. W., Braakhuis, B. J., Wedzinga, R., Noordhuis, P., Smid, K., ...

A class of new 5-fluorouracil (FU) analogues, the 5-fluoro-5,6-dihydro-6- alkoxy-uracils was synthesised with a modification at the 6-position of the pyrimidine ring. At this position the analogues...

Growth, morphology and chemosensitivity studies on postconfluent cells cultured in 'V'-bottomed microtiter plates.

Pizao, P. E., Lyaruu, D. M., Peters, G. J., Winograd, B., Giaccone, G., ...

This study assessed the growth pattern, cellular organisation and chemosensitivity of established human tumour cell lines growing as postconfluent cultures in 'V'-bottomed, 96-well microtiter plates....

In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.

Peters, G. J., Kraal, I., Pinedo, H. M.

Brequinar sodium (DUP-785; Brequinar) is a potent inhibitor of the pyrimidine de novo enzyme dihydroorotate dehydrogenase (DHO-DH), leading to a depletion of pyrimidine nucleotides, which could be...

DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?

Smitskamp-Wilms, E., Giaccone, G., Pinedo, H. M., Van Der Laan, B. F., Peters, G. J.

DT-diaphorase (DTD) is an important enzyme for the bioreductive activation of the new alkylating indoloquinone EO9. In preclinical studies, EO9 has shown selective anti-tumour activity against solid...

In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil.

Peters, G. J., Van Dijk, J., Laurensse, E., Van Groeningen, C. J., Lankelma, J., Leyva, A., ...

The effect of delayed uridine administration on the in vitro growth inhibitory effects of 5-fluorouracil (5FU) and on the in vivo antitumour activity and toxicity was studied. In vitro growth...

Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.

Peters, G. J., Braakhuis, B. J., De Bruijn, E. A., Laurensse, E. J., Van Walsum, M., Pinedo, H. M.

Four human head and neck xenograft (HNX) tumour lines grown in nude mice and two murine colon carcinomas (Colon 26 and 38) were tested for their sensitivity to 5-fluorouracil (5-FU) and its prodrug...

Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors

Lemos, C, Jansen, G, Peters, G J

Multidrug resistance is often associated with the (over)expression of drug efflux transporters of the ATP-binding cassette (ABC) protein family. This minireview discusses the role of one selected...

Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells

Temmink, O H, Hoebe, E K, Ackland, S P, Fukushima, M, Peters, G J

Oxaliplatin (OHP) is an anticancer agent that acts by formation of Platinum-DNA (Pt-DNA) adducts resulting in DNA-strand breaks and is used for the treatment of colorectal cancer. The pyrimidine...

Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels

Giovannetti, E, Backus, H H J, Wouters, D, Ferreira, C G, Brakenhoff, R H, ...

Colorectal cancer (CRC) resistance to fluoropyrimidines and other inhibitors of thymidylate synthase (TS) is a serious clinical problem often associated with increased intracellular levels of TS....

The hollow fibre assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells

Temmink, O H, Prins, H-J, Van Gelderop, E, Peters, G J

The Hollow Fibre Assay (HFA) is usually applied as an early in vivo model for anti-cancer drug screening, but is potentially an excellent model for short-term in vivo pharmacodynamic studies. We used...

The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia

Hubeek, I, Stam, R W, Peters, G J, Broekhuizen, R, Meijerink, J P P, Wering, E R Van, ...

Cytarabine (ara-C) is the most effective agent for the treatment of acute myeloid leukaemia (AML). Aberrant expression of enzymes involved in the transport/metabolism of ara-C could explain drug...

Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines

Pinedo, H M, Veerman, G, Bergman, A M, Kuiper, C M, Vermorken, J B, ...

Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines

Kroep, J R, Giaccone, G, Tolis, C, Voorn, D A, Loves, W J P, Groeningen, C J Van, ...

Gemcitabine and paclitaxel are active agents in the treatment of non-small-cell lung cancer (NSCLC). To optimize treatment drug combinations, simultaneously and 4 and 24 h intervals, were studied...

Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma

Kamm, Y J L, Peters, G J, Hull, W E, Punt, C J A, Heerschap, A

Role of platelet-derived endothelial cell growth factor/thymidine phosphorylase in fluoropyrimidine sensitivity

De Bruin, M, Van Capel, T, Kruyt, F A, Fukushima, M, Hoekman, K, ...

Increased sensitivity to gemcitabine of P-glycoprotein and multidrug resistance-associated protein-overexpressing human cancer cell lines

Bergman, A M, Pinedo, H M, Talianidis, I, Veerman, G, Loves, W J P, Van Der Wilt, C L, ...