Bowman, J. C., Abruzzo, G. K., Anderson, J. W., Flattery, A. M., Gill, C. J., Pikounis, V. B., ...
Caspofungin acetate (MK-0991) is an antifungal antibiotic that inhibits the synthesis of 1,3-β-d-glucan, an essential component of the cell wall of several pathogenic fungi. Caspofungin acetate was...
Bartizal, K, Scott, T, Abruzzo, G K, Gill, C J, Pacholok, C, Lynch, L, ...
Lipopeptide L-733560 is a hybrid analog of L-731373 and L-705589. All are water-soluble semisynthetic pneumocandin Bo derivatives. In vitro susceptibility testing of L-705589, L-731373, and L-733560...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Krupa, D, ...
The activities of the water-soluble pneumocandin derivatives L-733560, L-705589, and L-731373 were evaluated in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis and were...
Flattery, A M, Abruzzo, G K, Gill, C J, Smith, J G, Bartizal, K
A new model for the evaluation of antifungal compounds against oropharyngeal and gastrointestinal mucosal colonization by Candida albicans was developed. To simulate the immune deficiency observed in...
In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).
Bartizal, K, Gill, C J, Abruzzo, G K, Flattery, A M, Kong, L, Scott, P M, ...
The echinocandin MK-0991, formerly L-743,872, is a water-soluble lipopeptide that has been demonstrated in preclinical studies to have potent activity against Candida spp., Aspergillus fumigatus, and...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, ...
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The...
Douglas, C M, D'Ippolito, J A, Shei, G J, Meinz, M, Onishi, J, Marrinan, J A, ...
Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a...
Smith, J G, Kong, L, Abruzzo, G K, Gill, C J, Flattery, A M, Scott, P M, ...
Many animal models of Helicobacter infection have been described, including infection in rhesus monkeys, ferrets, gnotobiotic piglets, and mice. These animal models utilize a combination of detection...
A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.
Kong, L, Smith, J G, Bramhill, D, Abruzzo, G K, Bonfiglio, C, Cioffe, C, ...
Although many detection methods have been used to determine Helicobacter colonization in small animal models, the sensitivity and specificity of these detection methods are limited. To improve the...
Influence of six antifungal agents on the chemiluminescence response of mouse spleen cells.
Abruzzo, G K, Giltinan, D M, Capizzi, T P, Fromtling, R A
The luminol-enhanced chemiluminescence (CL) assay is a measure of the early events of phagocytosis, leukocyte activation, and immune cell interactions. Reduction in the CL response of immune cells...
Giltinan, D M, Capizzi, T P, Abruzzo, G K, Fromtling, R A
Chemiluminescence is the result of the respiratory burst generated by phagocytic cells after stimulation by antigen. The measurement of chemiluminescence represents a sensitive means for detecting...
Candida tropicalis infection in normal, diabetic, and neutropenic mice.
Fromtling, R A, Abruzzo, G K, Giltinan, D M
Opportunistic infections caused by Candida tropicalis have been noted with increasing frequency in compromised patients. The pathogenicity of three isolates of C. tropicalis was studied in normal...
Bowman, J. C., Abruzzo, G. K., Anderson, J. W., Flattery, A. M., Gill, C. J., Pikounis, V. B., ...
Caspofungin acetate (MK-0991) is an antifungal antibiotic that inhibits the synthesis of 1,3-β-d-glucan, an essential component of the cell wall of several pathogenic fungi. Caspofungin acetate was...
Bartizal, K, Scott, T, Abruzzo, G K, Gill, C J, Pacholok, C, Lynch, L, ...
Lipopeptide L-733560 is a hybrid analog of L-731373 and L-705589. All are water-soluble semisynthetic pneumocandin Bo derivatives. In vitro susceptibility testing of L-705589, L-731373, and L-733560...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Krupa, D, ...
The activities of the water-soluble pneumocandin derivatives L-733560, L-705589, and L-731373 were evaluated in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis and were...
Flattery, A M, Abruzzo, G K, Gill, C J, Smith, J G, Bartizal, K
A new model for the evaluation of antifungal compounds against oropharyngeal and gastrointestinal mucosal colonization by Candida albicans was developed. To simulate the immune deficiency observed in...
In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).
Bartizal, K, Gill, C J, Abruzzo, G K, Flattery, A M, Kong, L, Scott, P M, ...
The echinocandin MK-0991, formerly L-743,872, is a water-soluble lipopeptide that has been demonstrated in preclinical studies to have potent activity against Candida spp., Aspergillus fumigatus, and...
Abruzzo, G K, Flattery, A M, Gill, C J, Kong, L, Smith, J G, Pikounis, V B, ...
The in vivo activity of the Merck antifungal echinocandin drug candidate MK-0991 (L-743,872) was evaluated in mouse models of disseminated candidiasis, aspergillosis, and cryptococcosis. The...
Douglas, C M, D'Ippolito, J A, Shei, G J, Meinz, M, Onishi, J, Marrinan, J A, ...
Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a...
Smith, J G, Kong, L, Abruzzo, G K, Gill, C J, Flattery, A M, Scott, P M, ...
Many animal models of Helicobacter infection have been described, including infection in rhesus monkeys, ferrets, gnotobiotic piglets, and mice. These animal models utilize a combination of detection...
A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.
Kong, L, Smith, J G, Bramhill, D, Abruzzo, G K, Bonfiglio, C, Cioffe, C, ...
Although many detection methods have been used to determine Helicobacter colonization in small animal models, the sensitivity and specificity of these detection methods are limited. To improve the...
Influence of six antifungal agents on the chemiluminescence response of mouse spleen cells.
Abruzzo, G K, Giltinan, D M, Capizzi, T P, Fromtling, R A
The luminol-enhanced chemiluminescence (CL) assay is a measure of the early events of phagocytosis, leukocyte activation, and immune cell interactions. Reduction in the CL response of immune cells...
Giltinan, D M, Capizzi, T P, Abruzzo, G K, Fromtling, R A
Chemiluminescence is the result of the respiratory burst generated by phagocytic cells after stimulation by antigen. The measurement of chemiluminescence represents a sensitive means for detecting...
Candida tropicalis infection in normal, diabetic, and neutropenic mice.
Fromtling, R A, Abruzzo, G K, Giltinan, D M
Opportunistic infections caused by Candida tropicalis have been noted with increasing frequency in compromised patients. The pathogenicity of three isolates of C. tropicalis was studied in normal...
Efficacy of Caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans▿
Bowman, J. C., Abruzzo, G. K., Flattery, A. M., Gill, C. J., Hickey, E. J., Hsu, M. J., ...
The echinocandin caspofungin is a potent inhibitor of the activity of 1,3-β-d-glucan synthase from Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans. In murine models of disseminated...