Goodyear, L J, Giorgino, F, Sherman, L A, Carey, J, Smith, R J, Dohm, G L
To determine whether the impaired insulin-stimulated glucose uptake in obese individuals is associated with altered insulin receptor signaling, we measured both glucose uptake and early steps in the...
Dohm, G L, Tapscott, E B, Pories, W J, Dabbs, D J, Flickinger, E G, Meelheim, D, ...
We have developed an in vitro muscle preparation suitable for metabolic studies with human muscle tissue and have investigated the effects of obesity and non-insulin-dependent diabetes mellitus...
Caro, J F, Sinha, M K, Raju, S M, Ittoop, O, Pories, W J, Flickinger, E G, ...
We have studied the structure and function of the insulin receptors in obese patients with and without noninsulin dependent diabetes mellitus (NIDDM) and in nonobese controls using partially purified...
Friedman, J E, Dohm, G L, Leggett-Frazier, N, Elton, C W, Tapscott, E B, Pories, W P, ...
A major defect contributing to impaired insulin action in human obesity is reduced glucose transport activity in skeletal muscle. This study was designed to determine whether the improvement in whole...
Ahmad, F, Azevedo, J L, Cortright, R, Dohm, G L, Goldstein, B J
Obese human subjects have increased protein-tyrosine phosphatase (PTPase) activity in adipose tissue that can dephosphorylate and inactivate the insulin receptor kinase. To extend these findings to...
Kern, M, Wells, J A, Stephens, J M, Elton, C W, Friedman, J E, Tapscott, E B, ...
Glucose transport in skeletal muscle is mediated by two distinct transporter isoforms, designated muscle/adipose glucose transporter (Glut4) and erythrocyte/HepG2/brain glucose transporter (Glut1),...
Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats.
Dolan, P L, Tapscott, E B, Dorton, P J, Dohm, G L
Both insulin and contraction stimulate glucose transport in skeletal muscle. Insulin-stimulated glucose transport is decreased in obese humans and rats. The aims of this study were (1) to determine...
The effect of fasting on the activation in vivo of the insulin receptor kinase.
Contreras, I, Dohm, G L, Abdallah, S, Wells, J A, Mooney, N, Rovira, A, ...
Fasting causes insulin resistance in liver and fat, and increases insulin sensitivity in muscle. We studied the response in vitro and in vivo to insulin of the insulin receptor tyrosine kinase in...
Transcriptional regulation of muscle fatty acid-binding protein.
Carey, J O, Neufer, P D, Farrar, R P, Veerkamp, J H, Dohm, G L
Heart fatty acid-binding protein (H-FABP) is present in a wide variety of tissues but is found in the highest concentration in cardiac and red skeletal muscle. It has been proposed that the...
Burguera, B, Elton, C W, Caro, J F, Tapscott, E B, Pories, W J, Dimarchi, R, ...
Although the growth-promoting effects of insulin-like growth factor II (IGF-II) have been intensively studied, the acute actions of this hormone on glucose metabolism have been less well evaluated,...
Activities of glucokinase and hexokinase in mammalian and avian livers.
Stanley, J C, Dohm, G L, McManus, B S, Newsholme, E A
A radiochemical assay for glucokinase activity was developed for use in high-speed supernatants of liver. The maximum activities of glucokinase ranged from 0.4 to 3.8 mumol/min per g fresh wt. at 30...
Espinal, J, Dohm, G L, Newsholme, E A
The half-maximal stimulation of the rates of glycolysis and glycogen synthesis in soleus-muscle strips from sedentary animals occurred at a concentration of insulin of about 100 microunits/ml. In...
Metabolic control of hepatic gluconeogenesis during exercise.
Prolonged exercise increased the concentrations of the hexose phosphates and phosphoenolpyruvate and depressed those of fructose 1,6-bisphosphate, triose phosphates and pyruvate in the liver of the...
Fatty acid oxidation by liver and muscle preparations of exhaustively exercised rats.
Barakat, H A, Kasperek, G J, Dohm, G L, Tapscott, E B, Snider, R D
The influence of exhaustive exercise on the capacity of liver and muscle of rats to oxidize fatty acids was investigated in vitro. The rate of oxidation of fatty acids by liver preparations was...
The role of lysosomes in exercise-induced hepatic protein loss.
Kasperek, G J, Dohm, G L, Barakat, H A, Strausbauch, P H, Barnes, D W, Snider, R D
Previous reports have shown that exercise causes a loss of liver protein. The purpose of the present study was to elucidate the mechanism of this exercise-induced protein loss. Exercise caused: (1)...
Effect of exercise on synthesis and degradation of muscle protein.
Dohm, G L, Kasperek, G J, Tapscott, E B, Beecher, G R
Several reports have shown that amino acid utilization via oxidation and gluconeogenesis is increased during exercise. The purpose of this study was to investigate whether these changes are...
Dohm, G L, Hecker, A L, Brown, W E, Klain, G J, Puente, F R, Askew, E W, ...
This study was conducted to investigate alterations in excretion of urea and total nitrogen after6-8 weeks of daily exercise and to establish if the capacity for amino acid oxidation in muscle is...
A new paradigm for type 2 diabetes mellitus: could it be a disease of the foregut?
Hickey, M S, Pories, W J, MacDonald, K G, Cory, K A, Dohm, G L, Swanson, M S, ...
SUMMARY BACKGROUND DATA: We previously reported, in a study of 608 patients, that the gastric bypass operation (GB) controls type 2 diabetes mellitus in the morbidly obese patient more effectively...
Is type II diabetes mellitus (NIDDM) a surgical disease?
Pories, W J, MacDonald, K G, Flickinger, E G, Dohm, G L, Sinha, M K, Barakat, H A, ...
Since February 1, 1980, 515 morbidly obese patients have undergone the Greenville gastric bypass (GGB) operation. Of these, 212 (41.2%) were euglycemic, 288 (55.9%) were either diabetic or had...
Goodyear, L J, Giorgino, F, Sherman, L A, Carey, J, Smith, R J, Dohm, G L
To determine whether the impaired insulin-stimulated glucose uptake in obese individuals is associated with altered insulin receptor signaling, we measured both glucose uptake and early steps in the...
Dohm, G L, Tapscott, E B, Pories, W J, Dabbs, D J, Flickinger, E G, Meelheim, D, ...
We have developed an in vitro muscle preparation suitable for metabolic studies with human muscle tissue and have investigated the effects of obesity and non-insulin-dependent diabetes mellitus...
Caro, J F, Sinha, M K, Raju, S M, Ittoop, O, Pories, W J, Flickinger, E G, ...
We have studied the structure and function of the insulin receptors in obese patients with and without noninsulin dependent diabetes mellitus (NIDDM) and in nonobese controls using partially purified...
Friedman, J E, Dohm, G L, Leggett-Frazier, N, Elton, C W, Tapscott, E B, Pories, W P, ...
A major defect contributing to impaired insulin action in human obesity is reduced glucose transport activity in skeletal muscle. This study was designed to determine whether the improvement in whole...
Ahmad, F, Azevedo, J L, Cortright, R, Dohm, G L, Goldstein, B J
Obese human subjects have increased protein-tyrosine phosphatase (PTPase) activity in adipose tissue that can dephosphorylate and inactivate the insulin receptor kinase. To extend these findings to...
Kern, M, Wells, J A, Stephens, J M, Elton, C W, Friedman, J E, Tapscott, E B, ...
Glucose transport in skeletal muscle is mediated by two distinct transporter isoforms, designated muscle/adipose glucose transporter (Glut4) and erythrocyte/HepG2/brain glucose transporter (Glut1),...
Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats.
Dolan, P L, Tapscott, E B, Dorton, P J, Dohm, G L
Both insulin and contraction stimulate glucose transport in skeletal muscle. Insulin-stimulated glucose transport is decreased in obese humans and rats. The aims of this study were (1) to determine...
The effect of fasting on the activation in vivo of the insulin receptor kinase.
Contreras, I, Dohm, G L, Abdallah, S, Wells, J A, Mooney, N, Rovira, A, ...
Fasting causes insulin resistance in liver and fat, and increases insulin sensitivity in muscle. We studied the response in vitro and in vivo to insulin of the insulin receptor tyrosine kinase in...
Transcriptional regulation of muscle fatty acid-binding protein.
Carey, J O, Neufer, P D, Farrar, R P, Veerkamp, J H, Dohm, G L
Heart fatty acid-binding protein (H-FABP) is present in a wide variety of tissues but is found in the highest concentration in cardiac and red skeletal muscle. It has been proposed that the...
Burguera, B, Elton, C W, Caro, J F, Tapscott, E B, Pories, W J, Dimarchi, R, ...
Although the growth-promoting effects of insulin-like growth factor II (IGF-II) have been intensively studied, the acute actions of this hormone on glucose metabolism have been less well evaluated,...
Activities of glucokinase and hexokinase in mammalian and avian livers.
Stanley, J C, Dohm, G L, McManus, B S, Newsholme, E A
A radiochemical assay for glucokinase activity was developed for use in high-speed supernatants of liver. The maximum activities of glucokinase ranged from 0.4 to 3.8 mumol/min per g fresh wt. at 30...
Espinal, J, Dohm, G L, Newsholme, E A
The half-maximal stimulation of the rates of glycolysis and glycogen synthesis in soleus-muscle strips from sedentary animals occurred at a concentration of insulin of about 100 microunits/ml. In...
Metabolic control of hepatic gluconeogenesis during exercise.
Prolonged exercise increased the concentrations of the hexose phosphates and phosphoenolpyruvate and depressed those of fructose 1,6-bisphosphate, triose phosphates and pyruvate in the liver of the...
Fatty acid oxidation by liver and muscle preparations of exhaustively exercised rats.
Barakat, H A, Kasperek, G J, Dohm, G L, Tapscott, E B, Snider, R D
The influence of exhaustive exercise on the capacity of liver and muscle of rats to oxidize fatty acids was investigated in vitro. The rate of oxidation of fatty acids by liver preparations was...
The role of lysosomes in exercise-induced hepatic protein loss.
Kasperek, G J, Dohm, G L, Barakat, H A, Strausbauch, P H, Barnes, D W, Snider, R D
Previous reports have shown that exercise causes a loss of liver protein. The purpose of the present study was to elucidate the mechanism of this exercise-induced protein loss. Exercise caused: (1)...
Effect of exercise on synthesis and degradation of muscle protein.
Dohm, G L, Kasperek, G J, Tapscott, E B, Beecher, G R
Several reports have shown that amino acid utilization via oxidation and gluconeogenesis is increased during exercise. The purpose of this study was to investigate whether these changes are...
Dohm, G L, Hecker, A L, Brown, W E, Klain, G J, Puente, F R, Askew, E W, ...
This study was conducted to investigate alterations in excretion of urea and total nitrogen after6-8 weeks of daily exercise and to establish if the capacity for amino acid oxidation in muscle is...
A new paradigm for type 2 diabetes mellitus: could it be a disease of the foregut?
Hickey, M S, Pories, W J, MacDonald, K G, Cory, K A, Dohm, G L, Swanson, M S, ...
SUMMARY BACKGROUND DATA: We previously reported, in a study of 608 patients, that the gastric bypass operation (GB) controls type 2 diabetes mellitus in the morbidly obese patient more effectively...
Is type II diabetes mellitus (NIDDM) a surgical disease?
Pories, W J, MacDonald, K G, Flickinger, E G, Dohm, G L, Sinha, M K, Barakat, H A, ...
Since February 1, 1980, 515 morbidly obese patients have undergone the Greenville gastric bypass (GGB) operation. Of these, 212 (41.2%) were euglycemic, 288 (55.9%) were either diabetic or had...