G. L. Scheffer

Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentation (2006)

Reurs, A.W., Schoonderwoerd, A.J., Jansen, G., Hooijberg, J.H., ...

Dendritic cells (DC) express the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and multidrug resistance protein 1 (MRP1; ABCC1). Functionally, both these transporters have been...

Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides (2006)

Zelcer, N., Wetering, K. Van De, Waart, R. De, Scheffer, G.L., Marschall, H.U., Wielinga, P.R., ...

Background/Aim: Multidrug Resistance Protein 3 (MRP3) transports bile salts and glucuronide conjugates in vitro and is postulated to protect the liver in cholestasis. Whether the absence of Mrp3...

Localization of Breast Cancer Resistance Protein (BCRP) in Microvessel Endothelium of Human Control and Epileptic Brain (2005)

Aronica, E.M.A., Gorter, J.A., Redeker, S, Vliet, E.A. Van, Ramkema, M., Scheffer, G.L., ...

Purpose: Breast cancer resistance protein (BCRP) is a half adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed on cellular membranes and included in the group of multidrug...

The topoisomerase I inhibitor DX-8951f is a poor substrate for the breast cancer resistance protein (2005)

Hattum, A.H. Van, Hoogsteen, I.J., Schlüper, H.M.M., Maliepaard, M., Scheffer, G.L., Scheper, R.J., ...

Localization of Breast Cancer Resistance Protein (BCRP) in Microvessel Endothelium of Human Control and Epileptic Brain (2005)

Aronica, E.M.A., Gorter, J.A., Redeker, S, Vliet, E.A. Van, Ramkema, M., Scheffer, G.L., ...

Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum (2005)

Hu, X., Scheffer, G.L., Toonstra, J., ...

Hypoxia-induced acidification causes mitoxantrone resistance not mediated by drug transporters in human breast cancer cells (2005)

Greijer, A.E., Jong, M.C. De, Scheffer, G.L., Shvarts, A., Diest, P.J. Van, Wall, E. Van Der

Hypoxia has clinically been associated with resistance to chemotherapy. The aim of this study was to investigate whether hypoxia induces resistance to doxorubicin and mitoxantrone, two common drugs...

Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy (2004)

Aronica, E., Gorter, J.A., Ramkema, M., Redeker, S., Ozbas-Gercer, F., Vliet, E.A. Van, ...

Purpose: This study investigated the cellular distribution of different multidrug resistance (MDR)-related proteins such as P-glycoprotein (P-gp), the multidrug resistance-associated proteins (MRP) 1...

Induction of breast cancer resistance protein by the camptothecin derivative DX-895f is associated with minor reduction of antitumour activity (2004)

Hattum, A.H. Van, Hoogsteen, I.J., Schlüper, H.M.M., Maliepaard, M., Scheffer, G.L., Scheper, R.J., ...

Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy (2004)

Aronica, E., Gorter, J.A., Ramkema, M., Redeker, S., Ozbas-Gercer, F., Vliet, E.A. Van, ...

Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: Focal cortical dysplasia and glioneuronal tumors (2003)

Aronica, E.M.A., Gorter, J.A., Jansen, G.H., Rijen, P.C. Van, Leenstra, S., ...

Overexpression of the human major vault protein in gangliogliomas (2003)

Aronica, E.M.A., Gorter, J.A., Vliet, E.A. Van, Spliet, W.G.M., Rijen, P.C. Van, ...

The formation of vault-tubes: a dynamic interaction between vaults and vault PARP (2003)

Zon, A. Van, Mossink, M.H., Schoester, M., Houtsmuller, A.B., Scheffer, G.L., Scheper, R.J., ...

Vaults are barrel-shaped cytoplasmic ribonucleoprotein particles that are composed of a major vault protein (MVP), two minor vault proteins [telomerase-associated protein 1 (TEP1), vault...

Molecular determinants of treatment response in human germ cell tumors (2003)

Mayer, F., Stoop, H., Scheffer, G.L., Scheper, R., Oosterhuis, J.W., Looijenga, L.H., ...

PURPOSE: Germ cell tumors (GCTs) are highly sensitive to cisplatin-based chemotherapy. This feature is unexplained, as is the intrinsic chemotherapy resistance of mature teratomas and the resistant...

Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1 (2003)

Scheffer, G.L., Broxterman, H.J., Hooijberg, J.H., Slootstra, J.W., Meloen, R.H., ...

Tumor cells may become resistant to conventional anticancer drugs through the occurrence of transmembrane transporter proteins such as P-glycoprotein (ABCB1), breast cancer resistance protein...

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria (2002)

Jonker, J.W., Buitelaar, M., Wagenaar, E., Valk, M. Van Der, Scheffer, G.L., Scheper, R.J., ...

Tissue distribution and induction of human multidrug resistant protein 3 (2002)

Scheffer, G.L., Kool, M., Haas, M. De, Bosman, D.K., ...

Disruption of the murine major vault protein (MVP/LRP) gene does not induce hypersensitivity to cytostatics (2002)

Mossink, M.H., Zon, A. Van, Franzel-Luiten, E., Schoester, M., Kickhoefer, V.A., Scheffer, G.L., ...

Vaults are ribonucleoprotein particles with a distinct structure and a high degree of conservation between species. Although no function has been assigned to the complex yet, there is some evidence...

The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites (2001)

Bladergroen, B.A., Strik, M.C.M., Bovenschen, N., Berkum, O. Van, Scheffer, G.L., ...

The wide spectrum of multidrug resistance 3 deficiency: From neonatal cholestasis to cirrhosis of adulthood (2001)

Jacquemin, E., Cresteil, D., Sokal, E.M., Sturm, E., Dumont, M., ...

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier (2000)

Wijnholds, J., Scheffer, G.L., Valk, M. Van Der, ...

Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies (2000)

Scheffer, G.L., Kool, M., Heijn, M., Haas, M. De, Wijnholds, J., ...

Potent interaction of flavopiridol with MRP1 (1999)

Hooijberg, J.H., Broxterman, H.J., Scheffer, G.L., Vrasdonk, C., Heijn, M., Jong, M.C. De, ...

Multidrug resistance protein I protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage (1998)

Wijnholds, J., Scheffer, G.L., Valk, M. Van Der, Beijnen, J.H., Scheper, R.J., Borst, P.

Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines (1997)

Kool, M., Haas, M. De, Scheffer, G.L., Scheper, R.J., Juijn, J.A., ...

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Joghnson syndrome (1997)

Paulusma, C.C., Kool, M., Bosma, P.J., Scheffer, G.L., Borg, F. Ter, Scheper, R.J., ...

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome (1997)

Paulusma, C.C., Kool, M., Bosma, P.J., Scheffer, G.L., Borg, F. Ter, Scheper, R.J., ...

Analysis of expression of cMOAT (MRP2), MRP3, MRP4 and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines (1997)

Kool, M., Haas, M. De, Scheffer, G.L., Scheper, R.J., Juijn, J.A., ...

The drug-resistance-related protein LRP is the human major vault protein (1995)

Scheffer, G.L., Wijngaard, P.L.J., Flens, M.J., Izquierdo, M.A., Slovak, M.L., Pinedo, H.M., ...

Drug resistance-associated marker LRP for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma (1995)

Izquierdo, M.A., Zee, A. Van Der, Vermorken, J.B., Valk, P. Van Der, Giaccone, G., ...

The drug resistance-related protein LRP is the human major vault protein (1995)

Scheffer, G.L., Wijngaard, P.L.J., Flens, M.J., Izquierdo, M.A., Slovak, M.L., Pinedo, H.M., ...

Overexpression of Mr110,000 vesicular protein in non-P-glycoprotein mediated multidrug-resistance (1993)

Scheper, R.J., Broxterman, H.J., Scheffer, G.L., Kaaijk, P., Dalton, W.S., ...

Drug transporter proteins in clinical multidrug-resistance (1992)

Scheper, R.J., Broxterman, H.J., Scheffer, G.L., Pinedo, H.M.

Differentiation dependent expression of P-glycoprotein in the normal and neoplastic human kidney (1991)

Kalken, C.K. Van, Valk, P. Van Der, Hadisaputro, M.M.N., Pieters, R., Broxterman, H.J., Kuiper, C.M., ...

Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein (1991)

Schuurhuis, G.J., Broxterman, H.J., Pinedo, H.M., Heijningen, H.M. Van, Kuiper, C.M., ...

Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues.

Schroeijers, A. B., Scheffer, G. L., Flens, M. J., Meijer, G. A., Izquierdo, M. A., ...

Multidrug resistant cancer cells frequently overexpress the 110-kd lung resistance-related protein (LRP) as detected with the monoclonal antibody (MAb) LRP-56. Recently, we identified LRP as the...

Tissue distribution of the multidrug resistance protein.

Flens, M. J., Zaman, G. J., Izquierdo, M. A., Schroeijers, A. B., Scheffer, G. L., ...

The human multidrug resistance protein (MRP) is a 190 kd membrane glycoprotein that can cause resistance of human tumor cells to various anticancer drugs, by extruding these drugs out of the cell....

Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumors.

Izquierdo, M. A., Scheffer, G. L., Flens, M. J., Giaccone, G., Broxterman, H. J., Meijer, C. J., ...

Multidrug resistance (MDR) to anticancer drugs is a major cause of treatment failure in cancer. The lung resistance protein LRP is a newly described protein related to MDR in several in vitro models....

Membrane transport proteins associated with drug resistance expressed in human melanoma.

Schadendorf, D., Makki, A., Stahr, C., Van Dyck, A., Wanner, R., Scheffer, G. L., ...

Melanoma cells often display a multidrug-resistant phenotype, but the mechanisms involved are largely unknown. We have studied here the recently identified transport-associated proteins, MRP and LRP,...

Multidrug resistance related molecules in human and murine lung

Scheffer, G L, Smit, E F, Müller, M, Postma, D S, Timens, W, ...

Aims: Transporter proteins known to mediate multidrug resistance (MDR) in tumour cells—MDR1 P-glycoprotein (P-gp) and multidrug resistance related protein 1 (MRP1)—are thought to be involved in...