Molecular mechanisms of Fas ligand-induced inflammation (2006)
Umemura, M., Kawabe, T., Kidoya, H., Shudo, K., Fukui, M., Asano, M., ...
Yoshikai, Y, Matsuzaki, G, Kishihara, K, Nomoto, K, Yokokura, T, Nomoto, K
To determine whether environmental antigens such as intestinal microflora contribute to expansion of the T-cell repertoire, age-related changes in the expression level of T-cell antigen receptor...
Hara, T, Mizuno, Y, Takaki, K, Takada, H, Akeda, H, Aoki, T, ...
Gamma delta T cell receptor-positive cells (gamma delta T cells) have recently been implicated to play a role in the protection against infectious pathogens. Serial studies on gamma delta T cells in...
Molecular mechanisms of Fas ligand-induced inflammation
Umemura, M., Kawabe, T., Kidoya, H., Shudo, K., Fukui, M., Asano, M., ...
Yoshikai, Y, Matsuzaki, G, Kishihara, K, Nomoto, K, Yokokura, T, Nomoto, K
To determine whether environmental antigens such as intestinal microflora contribute to expansion of the T-cell repertoire, age-related changes in the expression level of T-cell antigen receptor...
Hara, T, Mizuno, Y, Takaki, K, Takada, H, Akeda, H, Aoki, T, ...
Gamma delta T cell receptor-positive cells (gamma delta T cells) have recently been implicated to play a role in the protection against infectious pathogens. Serial studies on gamma delta T cells in...
Molecular mechanisms of Fas ligand-induced inflammation
Umemura, M., Kawabe, T., Kidoya, H., Shudo, K., Fukui, M., Asano, M., ...
Kadena, T, Matsuzaki, G, Fujise, S, Kishihara, K, Takimoto, H, Sasaki, M, ...
T-cell receptor (TCR) alpha beta+ CD4- CD8- (double-negative; DN) T cells appear in the peritoneal cavity at an early stage of intraperitoneal (i.p.) infection with the intracellular pathogen...
Matsuzaki, G, Sonoda, K H, Mukasa, A, Yamada, H, Nakamura, T, Ikebe, H, ...
A unilateral infection of Listeria monocytogenes into the testis of mice induces not only Listeria-specific T cells but also autoreactive T cells that can transfer experimental autoimmune orchitis...
Macrophages activated by Listeria monocytogenes induce organ-specific autoimmunity.
Sonoda, K H, Matsuzaki, G, Nomura, A, Yamada, H, Hamano, S, Nakamura, T, ...
We have previously reported an experimental autoimmune model induced by the local infection of Listeria monocytogenes. The unilateral inoculation of virulent Listeria into a testis of a normal mouse...
Nomura, A, Matsuzaki, G, Takada, H, Hiromatsu, K, Nabeshima, S, Nakamura, T, ...
The role of T-cell receptor (TCR) gammadelta T cells in the induction of protective TCR alphabeta T cells against infection by the intracellular bacteria Listeria monocytogenes was analysed. We found...
Gamma delta T cells in infection-induced and autoimmune-induced testicular inflammation.
Mukasa, A, Yoshida, H, Kobayashi, N, Matsuzaki, G, Nomoto, K
In a previous report, we investigated inflammatory responses induced by injecting Listeria monocytogenes into one testis of a mouse. We demonstrated that the contralateral testis also developed an...
Kurosawa, S, Harada, M, Matsuzaki, G, Shinomiya, Y, Terao, H, Kobayashi, N, ...
Natural killer (NK) cells that infiltrated into the primary tumour site at an early stage of tumour development, were examined for their participation in the generation of anti-tumour cytotoxic T...
Matsuzaki, G, Song, F, Nomoto, K
Injection of goat anti-mouse IgD antibodies (GAM IgD) to mice has been shown to induce polyclonal IgG1 and IgE production by B cells and interleukin-4 (IL-4) production by goat Ig-specific T cells....
The induction of renal autoantigen-specific T cells by a local Listeria monocytogenes infection.
Sonoda, K, Mukasa, A, Matsuzaki, G, Nomoto, K
In order to examine the possibility that a local chronic infection can induce organ-specific autoimmune disease, we inoculated unilateral kidneys with viable Listeria monocytogenes (intrarenal...
Yoshikai, Y, Matsuzaki, G, Inoue, T, Nomoto, K
It has been reported previously that environmental antigens such as intestinal microflora play an important role in an age-associated increase in number of T-cell receptor gamma/delta-bearing T...
Ohga, S, Yoshikai, Y, Kishihara, K, Matsuzaki, G, Ogimoto, M, Nomoto, K
In order to search for a possible role of abnormally proliferating T cells in developing autoimmune disease in lpr mice, and to define the difference of the T cells among various lpr-congeneic mice...
The stage of negative selection in tolerance induction in neonatal mice.
Ando, T, Yoshikai, Y, Matsuzaki, G, Takimoto, H, Nomoto, K
In flow microfluorometry analysis of thymus and lymph node cells of C57BL/6(I-E-,Mlsb) mice rendered neonatally tolerant to (C57BL/6 x AKR/J)F1 (I-E+,Mlsb/a) lymphoid cells, both CD4+ and CD8+ cells...
Yoshikai, Y, Takeda, Y, Ohga, S, Kishihara, K, Matsuzaki, G, Nomoto, K
We have previously shown that extrathymic rearrangements of T-cell receptor (TcR) gamma and delta chain genes occur in the peripheral lymphoid tissues of athymic nude mice. To further determine where...
Ohga, S, Yoshikai, Y, Matsumoto, K, Kishihara, K, Matsuzaki, G, Nomoto, K
To search the abnormality in prethymic T-cell precursors in lpr/lpr(lpr) mice, rearrangement and expression of T-cell receptor (TcR) genes were investigated in long-term cultured bone marrow (LTBM)...
Ogimoto, M, Yoshikai, Y, Matsuzaki, G, Ohga, S, Matsumoto, K, Nomoto, K
Clonal deletion of T cells capable of recognizing both host-type Mls and donor-type Mls occurred in the peripheral mature T-cell pool in radiation bone marrow chimeras of two H-2-compatible...
Takada, H, Matsuzaki, G, Hiromatsu, K, Nomoto, K
We have reported that T cells bearing T-cell receptors (TcR) of gamma delta type (gamma delta T cells) appear in the peritoneal cavity in a relatively early stage of primary intraperitoneal (i.p.)...
Nabeshima, S, Hiromatsu, K, Matsuzaki, G, Mukasa, A, Takada, H, Yoshida, S, ...
To evaluate the hypothesis that gamma delta T cells participate in protective immunity against mycobacterial infection, we depleted gamma delta T cells from mice by administration of anti-T-cell...
Li, X Y, Matsuzaki, G, Yoshikai, Y, Muramori, K, Nomoto, K
L-selectin, which was first reported as MEL-14 antigen in mice, is a type of animal lectin and expressed on lymphocytes, neutrophils and macrophages. L-selectin has been reported to be a homing...
Matsuzaki, G, Hiromatsu, K, Yoshikai, Y, Muramori, K, Nomoto, K
It has been shown that T-cell receptor (TcR) gamma delta + CD4- CD8- T cells increase in number and have an important role in early protection in murine Listeria monocytogenes infection. In this...
Kobayashi, N, Matsuzaki, G, Yoshikai, Y, Seki, R, Ivanyi, J, Nomoto, K
The purpose of this paper was to study the gamma delta T-cell receptor repertoire and target specificity following stimulation of peripheral T cells of BALB/c mice with autologous or bacterial...
Takada, H, Matsuzaki, G, Yoshida, H, Sumichika, H, Nomoto, K
There is an increase in number of gamma delta T cells in the peritoneal cavity after intraperitoneal (i.p.) inoculation with Escherichia coli. The E. coli-induced gamma delta T cells in C3H/He mice...
Tamada, K, Harada, M, Ito, O, Takenoyama, M, Mori, T, Matsuzaki, G, ...
The mechanism by which murine tumour-infiltrating lymphocytes (TIL) decreased their anti-tumour activity during an in vitro culture with interleukin-2 (IL-2) was investigated. A phenotype analysis...
Ohga, S, Yoshikai, Y, Kishihara, K, Matsuzaki, G, Asano, T, Nomoto, K
An autosomal recessive gene, lpr, is responsible for lymphoproliferation and autoimmunity of lpr-mice, in which background genes are also known to influence the development of autoimmune disease. To...
TAKIZAWA, H, SATOH, M, OKAZAKI, H, MATSUZAKI, G, SUZUKI, N, ISHII, A, ...
A variety of cytokines have been implicated in the pathogenesis of pulmonary sarcoidosis, but the exact roles of IL-6 and IL-8 are not yet clear. We studied these cytokine levels in BALF from...
The protective role of T-cell receptor Vγ1+ T cells in primary infection with Listeria monocytogenes
Nakamura, T, Matsuzaki, G, Nomoto, K
We have previously reported that the T-cell receptor (TCR) γδ+ T cells increase in mice infected with an intracellular bacteria Listeria monocytogenes, and the cells predominantly express Vδ6 and...
Characterization of CD4– CD8– CD3+ T-cell receptor-αβ+ T cells in murine cytomegalovirus infection
Hossain, M S, Takimoto, H, Ninomiya, T, Yoshida, H, Kishihara, K, Matsuzaki, G, ...
In this study, we have investigated that after the intraperitoneal infection with murine cytomegalovirus (MCMV), the CD3+ CD4– CD8–(double negative; DN) T-cell receptor (TCR)αβ+ T cells...
Ninomiya, T, Takimoto, H, Matsuzaki, G, Hamano, S, Yoshida, H, Yoshikai, Y, ...
Cytomegalovirus (CMV) causes severe opportunistic infection in immunocompromised hosts. The importance of conventional αβ T cells in protection against CMV infection has been well documented....