Tytgat, G N, Wajs, E, Van Nueten, L, De Ridder, F, ...
As fundic dysaccommodation represents one of the pathophysiological mechanisms underlying functional dyspepsia, gastric relaxant agents may serve as a new treatment of this disorder. Previous studies...
Malfertheiner, P., Fass, R., Quigley, E. M. M., Modlin, I. M., Malagelada, J. R., Moss, S. F., ...
Copyright (C) 2006 Blackwell Publishing Ltd.
Kuiken, S.D., Klooker, T.K., Tytgat, G.N., Lei, A., Boeckxstaens, G.E.E.
Background: Visceral hypersensitivity is a consistent finding in a considerable proportion of patients with irritable bowel syndrome (IBS), and may provide a physiological basis for the development...
Boeckxstaens, G.E.E., Tytgat, G.N., Wajs, E., Nueten, L. Van, Ridder, F. De, Meulemans, A., ...
As fundic dysaccommodation represents one of the pathophysiological mechanisms underlying functional dyspepsia, gastric relaxant agents may serve as a new treatment of this disorder. Previous studies...
Background Acid pockets at the gastro-oesophageal junction escape buffering from meals in the stomach. Combining high-dose antacid with alginate may therefore be of benefit in gastro-oesophageal...
Prevalence and management of abdominal cramping and pain: a multinational survey (2006)
Quigley, E.M.M., Locke, G.R., Mueller-Lissner, S., Paulo, L.G., Tytgat, G.N., Helfrich, I., ...
Background Though functional gastrointestinal complaints are recognised as being common throughout the world, there have been few comparative studies of prevalence. Aim To compare the prevalence and...
Mueller-Lissner, S., Tytgat, G.N., Paulo, L.G., Quigley, E.M.M., Bubeck, J., Peil, H., ...
Aim To compare the efficacy and tolerability of oral hyoscine butylbromide (hereafter hyoscine) 10 mg t.d.s., paracetamol 500 mg t.d.s. and their fixed combination against placebo in patients with...
Malfertheiner, P., Fass, R., Quigley, E. M. M., Modlin, I. M., Malagelada, J. R., Moss, S. F., ...
Copyright (C) 2006 Blackwell Publishing Ltd.
Cancer of the esophagus and gastric cardia: recent advances (2004)
Tytgat, G.N., Bartelink, H., Bernards, R.A., Giacone, G., Lanschot, J.J. Van, Offerhaus, G.J., ...
Esophageal cancer and cancer of the gastric cardia, in particular adenocarcinomas, have shown a rapid and largely unexplained increase in incidence in many developed countries around the world. These...
Early diagnosis and prevention of sporadic colorectal cancer (2001)
Provenzale, D, Vainio, H, Dixon, M F, Atkin, W, ...
Descriptive Epidemiology Unit, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69372 cedex 08, France. lambert@iarc.fr
Tytgat, G N, Janssens, J, Reynolds, J C, Wienbeck, M
Academic Medical Centre, University of Amsterdam, The Netherlands.
Antithrombin III metabolism in patients with liver disease (1984)
Knot, E.A.R., Cate, J.W. Ten, Drijfhout, H.R., Kahle, L.H., Tytgat, G.N.
Endoscopical removal of an antireflux prosthesis (1983)
Les auteurs rapportent une complication rare des prothèses anti-reflux: la migration dans la cavité gastrique. L'extraction de la prothèse en forme de « C » a été effectuée avec succès à...
Janssens, J, Popiela, T, Kulig, J, Tytgat, G N, Huibregtse, K, ...
A multicenter study was conducted on 173 patients with active, endoscopically proven duodenal ulcers (158 men, 15 women). They were randomly assigned, in a double-blind manner, to two groups: those...
Endoscopic screening for malignancy in the gastric remnant (1981)
HUIBREGTSE, K., OFFERHAUS, J., VERHOEVEN, T., DE BOER, J., STADT, J. V. D., TYTGAT, G. N.
Dans une série de 2 790 patients soumis à une gastrectomie partielle pour lésion bénigne plus de 15 ans auparavant, 30 cas de carcinome sur moignon de gastrectomie restant ont été relevés...
WESDORP, I. C. E., BARTELSMAN, J., SCHIPPER, M. E. I., OFFERHAUS, J., TYTGAT, G. N.
14 patients porteurs d'udénocarcinome œsophagien entouré de muqueuse de type cylindrique (Barrett) ont été investigués sur le plan clinique, endoscopique et ont été soumis à une étude...
A new instrument for cleaning and disinfection of fiberendoscopes (1981)
HUIBREGTSE, K., HAVERKAMP, H. J., HOOGLAND, M. N., BURGER, G. H., BERTRAND, P. J. M., TYTGAT, G. N.
Les auteurs décrivent un appareil destiné au nettoyage et à la désinfection des fibroscopes, permettant en outre la stérilisation des fins canaux. Des contrôles bactériologiques réguliers ont...
Biliary excretion of ciprofloxacin and piperacillin in the obstructed biliary tract.
Van Den Hazel, S J, De Vries, X H, Speelman, P, Dankert, J, Tytgat, G N, Huibregtse, K, ...
Biliary excretion of ciprofloxacin and piperacillin was determined in cholestatic patients who had undergone endoscopic cholangiography. The median concentration of ciprofloxacin (n = 9) was 2.36...
Weel, J F, Van Der Hulst, R W, Gerrits, Y, Tytgat, G N, Dankert, J
Combination therapies that include metronidazole (MTZ) are the most successful therapies used in eradicating Helicobacter pylori. In this study, the prevalence and the relevance of heterogeneity in...
Pan, Z J, Van Der Hulst, R W, Feller, M, Xiao, S D, Tytgat, G N, Dankert, J, ...
Approximately 60% of Helicobacter pylori isolates in the Western world possess the cytotoxin-associated gene A (cagA). cagA-positive H. pylori is found to be associated with peptic ulcer disease...
Hoek, F J, Noach, L A, Rauws, E A, Tytgat, G N
We have compared the sensitivities, specificities, and predictive values of three commercial serological assays for the diagnosis of Helicobacter pylori infection. A qualitative latex method...
Identification of Campylobacter pyloridis isolates by restriction endonuclease DNA analysis.
Langenberg, W, Rauws, E A, Widjojokusumo, A, Tytgat, G N, Zanen, H C
Campylobacter pyloridis isolates recovered from gastric biopsy specimens of 16 patients were examined by restriction endonuclease DNA analysis with HindIII. For 8 of these 16 patients two different...
Metabolism of Fibrinogen in Cirrhosis of the Liver
Tytgat, G. N., Collen, D., Verstraete, M.
The metabolism of human fibrinogen labeled with radioactive iodine was studied in 50 patients with documented cirrhosis of the liver and in 35 healthy control subjects. Results in cirrhotic subjects...
No evidence for a prethrombotic state in stable chronic inflammatory bowel disease.
Knot, E, Ten Cate, J W, Leeksma, O C, Tytgat, G N, Vreeken, J
Ulcerative colitis and Crohn's disease are associated with a high risk of thromboembolic complications. The questions whether reported risk factors such as low antithrombin III concentrations,...
Antithrombin III metabolism in patients with liver disease.
Knot, E, Ten Cate, J W, Drijfhout, H R, Kahlé, L H, Tytgat, G N
Liver diseases are associated with complex haemostasis defects, in which platelets, coagulation, and fibrinolysis may all be affected. The low plasma concentrations of clotting factors often found...
Schultsz, C, Moussa, M, Van Ketel, R, Tytgat, G N, Dankert, J
AIMS: To determine whether inflammatory bowel disease (IBD) is associated with pathogenic or enteroadherent Escherichia coli. METHODS: A least two stool specimens and one rectal biopsy were taken...
Use of buffered formaldehyde in the enzymatic digestion of inflamed mucosa.
Meenan, J, Obradov, D O, Van Dullemen, H, Tytgat, G N, Van Deventer, S J
Mucosal inflammation is associated with altered expression of cell membrane molecules. Disaggregation of tissue for flow cytometry may introduce artefactual changes. In an attempt to prevent the...
Baas, I O, Van Rees, B P, Musler, A, Craanen, M E, Tytgat, G N, Van Den Berg, F M, ...
AIM: To evaluate similarities and differences between gastric stump cancer and conventional carcinoma in the non-operated stomach. METHODS: 26 stump carcinomas were compared with 24 conventional...
Interobserver variation in the histopathological scoring of Helicobacter pylori related gastritis.
Chen, X Y, Van Der Hulst, R W, Bruno, M J, Xiao, S D, Tytgat, G N, ...
AIM: To test the reproducibility between two histopathologists of features of Helicobacter pylori gastritis, using the updated Sydney classification. METHODS: 290 dyspeptic Dutch patients with biopsy...
Noach, L A, Rolf, T M, Tytgat, G N
AIM--To study the ultrastructural appearances of Helicobacter pylori in antral and duodenal biopsy specimens and its relation with the epithelial cells. METHODS--Endoscopically obtained antral and...
Witteman, E M, Mravunac, M, Becx, M J, Hopman, W P, Verschoor, J S, Tytgat, G N, ...
AIMS--To investigate the effect of eradication of Helicobacter pylori infection on gastric epithelial damage and gastritis, scored according to the Sydney system. METHODS--Gastritis scores and...
Interaction of cholesterol-crystallization-promoting proteins with vesicles.
De Bruijn, M A, Goldhoorn, B G, Zijlstra, A I, Tytgat, G N, Groen, A K
In this study, the interaction of mucin and concanavalin A-binding proteins isolated from human bile with cholesterol/phospholipid vesicles was investigated. Using resonance energy transfer assays...
Mechanism of bile salt-induced mucin secretion by cultured dog gallbladder epithelial cells.
Klinkspoor, J H, Tytgat, G N, Lee, S P, Groen, A K
1. Hypersecretion of gallbladder mucin has been proposed to be a pathogenic factor in cholesterol gallstone formation. Using cultured gallbladder epithelial cells, we demonstrated that bile salts...
Benign biliary strictures. Surgery or endoscopy?
Davids, P H, Tanka, A K, Rauws, E A, Van Gulik, T M, Van Leeuwen, D J, De Wit, L T, ...
OBJECTIVE: This study compared the results of surgery and endoscopy for benign biliary strictures in one institution, over the same period of time and with the same outcome definitions. SUMMARY...
Meuwissen, S G, Dekker-Saeys, B J, Agenant, D, Tytgat, G N
To establish the prevalence of inflammatory bowel disease in ankylosing spondylitis (AS), 79 AS patients underwent detailed medical screening, including sigmoidoscopic and roentgenological...
Dekker-Saeys, B J, Meuwissen, S G, De Haas, W H, Agenant, D, Tytgat, G N
To establish the prevalence of peripheral arthritis, radiographic sacroiliitis, and ankylosing spondylitis in patients with inflammatory bowel disease, 58 consecutive patients suffering from...
Dekker-Saeys, B J, Meuwissen, S G, De Haas, W H, Meijers, K A, Tytgat, G N
A study was made, in co-operation with several gastroenterology and rheumatology centres, of the clinical and genetic characteristics (HLA B27) of 50 patients suffering from both inflammatory bowel...
Meenan, J, Spaans, J, Grool, T A, Pals, S T, Tytgat, G N, Van Deventer, S J
BACKGROUND AND AIMS: Expression of alpha 4 beta 7 on memory T lymphocytes identifies a cell population that preferentially migrates to the gut. Detection of alpha 4 beta 7 on circulating lymphocytes...
CD4 antibody treatment in patients with active Crohn's disease: a phase 1 dose finding study.
Stronkhorst, A, Radema, S, Yong, S L, Bijl, H, Ten Berge, I J, Tytgat, G N, ...
BACKGROUND: T cells play an important part in Crohn's disease. Immunomodulating therapies that target T cell activation may have clinical effects in Crohn's disease. AIM: To investigate the toxicity...
Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum.
Craanen, M E, Dekker, W, Blok, P, Ferwerda, J, Tytgat, G N
To study the relationship between intestinal metaplasia and Helicobacter pylori infection, 2274 gastroscopic antral biopsies taken from 533 patients were examined. Overall, intestinal metaplasia was...
Endosonography in diagnosing and staging duodenal villous adenoma.
Tio, T L, Sie, L H, Verbeek, P C, Dé Wit, L T, Tytgat, G N
Endosonography was carried out in a patient with an extensive juxtapapillary tumour. Radiology and endoscopy were unable to distinguish a villous adenoma from an invasive carcinoma. Endosonography...
Gastric metaplasia and Helicobacter pylori infection.
Noach, L A, Rolf, T M, Bosma, N B, Schwartz, M P, Oosting, J, Rauws, E A, ...
Duodenal and antral mucosal biopsy specimens were obtained from 139 patients with dyspeptic complaints to study the prevalence and extent of gastric metaplasia in the duodenal bulb in relation to...
Polarised interleukin 8 secretion by HT 29/19A cells.
Lammers, K M, Jansen, J, Bijlsma, P B, Ceska, M, Tytgat, G N, Laboisse, C L, ...
Interleukin 8 is a neutrophil chemotactic and stimulating cytokine induced by various inflammatory stimuli, including tumour necrosis factor, interleukin 1, and endotoxin. The ability of HT 29/19A...
Helicobacter pylori and early gastric cancer.
Craanen, M E, Blok, P, Dekker, W, Tytgat, G N
The relation between Helicobacter pylori, intestinal metaplasia, and early gastric cancer was studied by examining gastrectomy specimens from 31 intestinal type and 22 diffuse type carcinomas. A...
Davids, P H, Ringers, J, Rauws, E A, De Wit, L T, Huibregtse, K, Van Der Heyde, M N, ...
This study describes the value of endoscopic retrograde cholangiopancreatography (ERCP) in patients with bile duct injury after laparoscopic cholecystectomy. Twelve consecutive patients were studied...
Bergman, J J, Groen, A K, Huibregtse, K, Tytgat, G N
There is a discrepancy between in vitro cholesterol dissolving efficacy of methyl-tert-butyl ether (MTBE) and ethyl propionate and cholesterol gall stone dissolution in vivo. This study investigated...
Clogging of biliary endoprostheses: a new perspective.
Coene, P P, Groen, A K, Cheng, J, Out, M M, Tytgat, G N, Huibregtse, K
Endoscopic palliation with biliary endoprostheses is now an established treatment for benign and malignant strictures of the biliary tree. These endoprostheses, however, tend to clog with time. We...
Subtypes of intestinal metaplasia and Helicobacter pylori.
Craanen, M E, Blok, P, Dekker, W, Ferwerda, J, Tytgat, G N
To determine whether there is a relationship between the presence of H pylori and the various subtypes of intestinal metaplasia in the gastric antrum, 2274 antral gastroscopic biopsies from 533...
Postoperative bile leakage: endoscopic management.
Davids, P H, Rauws, E A, Tytgat, G N, Huibregtse, K
Bile leakage is an infrequent but serious complication after biliary tract surgery. This non-randomised single centre study evaluated the endoscopic management of this problem in 55 consecutive...
Chronology of p53 protein accumulation in gastric carcinogenesis.
Craanen, M E, Blok, P, Dekker, W, Offerhaus, G J, Tytgat, G N
p53 Protein accumulation in early gastric carcinoma was studied in relation to the histological type (Lauren classification) and the type of growth pattern, including the chronology of p53 protein...
Absence of ras gene mutations in early gastric carcinomas.
Craanen, M E, Blok, P, Top, B, Boerrigter, L, Dekker, W, Offerhaus, G J, ...
The aims of this study were to assess the prevalence and type of activating point mutations at codons 12, 13, and 61 of the Ki-, Ha-, and N-ras genes in a series of early gastric carcinomas in white...
Treatment of bile duct lesions after laparoscopic cholecystectomy.
Bergman, J J, Van Den Brink, G R, Rauws, E A, De Wit, L, Obertop, H, Huibregtse, K, ...
From January 1990 to June 1994, 53 patients who sustained bile duct injuries during laparoscopic cholecystectomy were treated at the Amsterdam Academic Medical Centre. There were 16 men and 37 women...
Mechanisms underlying neutrophil adhesion to apical epithelial membranes.
Meenan, J, Mevissen, M, Monajemi, H, Radema, S A, Soule, H R, Moyle, M, ...
Crypt abscesses allow prolonged apposition of activated neutrophils to the epithelial surface of the colon. Adhesion of neutrophils to both the vascular endothelium and basolateral epithelial...
Hommes, D W, Meenan, J, De Haas, M, Ten Kate, F J, Von Dem Borne, A E, Tytgat, G N, ...
BACKGROUND--Activated neutrophils cause tissue injury in inflammatory bowel disease (IBD). Upon activation, they shed soluble Fc gamma IIIb receptors (sFc gamma RIIIb). The subsequent inflammatory...
Meuwissen, S G, Feltkamp-Vroom, T M, De La Rivière, A B, Von Dem Borne, A E, Tytgat, G N
Lympho-plasmacytic infiltrates in cryostat sections (resected small intestine or colon specimens and rectal biopsies) from 29 patients with Crohn's disease (CD) were studied with the immunoperoxidase...
Impaired anamnestic cellular immune response in patients with Crohn's disease.
Meuwissen, S G, Schellekens, P T, Huismans, L, Tytgat, G N
The cellular immune system was studied in patients with Crohn's disease (CD), not receiving corticosteroids, or azathioprine, by means of in vitro and in vivo methods. It was found, that the in vitro...
The endoscopic techniques for introducing a large calibre (3.2 mm) biliary endoprosthesis to relieve jaundice are described. In 45 patients such an endoprosthesis was successfully introduced. The...
Effect of long-term treatment with cimetidine and antacids in Barrett's oesophagus.
Wesdorp, I C, Bartelsman, J, Schipper, M E, Tytgat, G N
The effect of a long-term treatment (one to two years) with cimetidine (1.6 g per day) and an antacid (Regla pH) was evaluated in nine patients with a Barrett's oesophagus. The results showed that...
Treatment of instrumental oesophageal perforation.
Wesdorp, I C, Bartelsman, J F, Huibregtse, K, Den Hartog Jager, F C, Tytgat, G N
Results of a conservative approach in the treatment of instrumental oesophageal perforation were evaluated in 54 patients. The perforations occurred either during introduction of/or manipulation with...
Improved specificity of the PABA test with p-aminosalicylic acid (PAS).
Hoek, F J, Van Den Bergh, F A, Klein Elhorst, J T, Meijer, J L, Timmer, E, Tytgat, G N
Until now use of the PABA test together with [14C] PABA to calculate the PABA excretion index has probably been the best adaptation suggested to enhance the specificity of this non-invasive...
Recurrent massive haematemesis from Dieulafoy vascular malformations--a review of 101 cases.
Veldhuyzen Van Zanten, S J, Bartelsman, J F, Schipper, M E, Tytgat, G N
Offerhaus, G J, Tersmette, A C, Huibregtse, K, Tersmette, K W, Stijnen, T, ...
Mortality caused by stomach cancer was analysed in a cohort of 2633 postgastrectomy patients who underwent surgery for benign conditions in the academic medical centre of the University of Amsterdam...
14C-urea breath test in C pylori gastritis.
Rauws, E A, Royen, E A, Langenberg, W, Woensel, J V, Vrij, A A, Tytgat, G N
14C-urea breath test was used to detect Campylobacter pylori colonisation in 129 consecutive non-ulcer dyspepsia patients. Fasting patients were given 3 microCi (110 kBq) of 14C-labelled urea after a...
Is encopresis always the result of constipation?
Benninga, M A, Büller, H A, Heymans, H S, Tytgat, G N, Taminiau, J A
Encopresis is often the result of chronic constipation in the majority of paediatric patients. In clinical practice, however, encopresis is also seen without constipation and it is unknown whether...
Medical therapy of gastroesophageal reflux disease in secondary and tertiary care settings.
Gastroesophageal reflux disease (GERD) is common. Many patients with recurring or troublesome symptoms are referred for endoscopic examination. Patients seen in secondary care usually have failed OTC...