G. Paul Matherne

Cardiovascular magnetic resonance of pulmonary artery growth and ventricular function after Norwood procedure with Sano modification (2008)

Lim, D Scott, Peeler, Benjamin B, Matherne, G Paul, Kramer, Christopher M

Abstract For hypoplastic left heart syndrome (HLHS), there have been concerns regarding pulmonary artery growth and ventricular dysfunction after first stage surgery consisting of the Norwood...

Adenosine receptor-mediated coronary vascular protection in post-ischemic mouse heart (2006)

Zatta, Amanda Jane, Matherne, G. Paul, Headrick, John Patrick

This study evaluated the ability of A1 and A3 adenosine receptor (AR) agonism, and A1, A2A, A2B and A3AR antagonism (revealing "intrinsic" responses), to modify post-ischemic coronary dysfunction in...

Adenosine receptor-mediated coronary vascular protection in post-ischemic mouse heart (2006)

Zatta, Amanda Jane, Matherne, G. Paul, Headrick, John Patrick

This study evaluated the ability of A1 and A3 adenosine receptor (AR) agonism, and A1, A2A, A2B and A3AR antagonism (revealing "intrinsic" responses), to modify post-ischemic coronary dysfunction in...

Adenosine receptor-mediated coronary vascular protection in post-ischemic mouse heart (2006)

Zatta, Amanda Jane, Matherne, G. Paul, Headrick, John Patrick

This study evaluated the ability of A1 and A3 adenosine receptor (AR) agonism, and A1, A2A, A2B and A3AR antagonism (revealing "intrinsic" responses), to modify post-ischemic coronary dysfunction in...

Adenosine receptor-mediated coronary vascular protection in post-ischemic mouse heart (2006)

Zatta, Amanda Jane, Matherne, G. Paul, Headrick, John Patrick

This study evaluated the ability of A1 and A3 adenosine receptor (AR) agonism, and A1, A2A, A2B and A3AR antagonism (revealing "intrinsic" responses), to modify post-ischemic coronary dysfunction in...

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Effects of A1 adenosine receptor overexpression on normoxic and post-ischemic gene expression (2003)

Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Lankford, Amy R., Matherne, G. Paul, Grimmond, Sean, ...

Objectives: To identify potential molecular genetic determinants of cardiovascular ischemic tolerance in wild-type and transgenic hearts overexpressing A1 adenosine receptors (A1ARs). Methods: cDNA...

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression (2003)

Headrick, John Patrick, Willems, Laura, Ashton, Kevin John, Holmgren, Kirsty, Peart, Jason Nigel John, Matherne, G. Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Altered signal transduction in cardiac ventricle overexpressing A1-adenosine receptors (2003)

Neumann, Joachim, Boknik, Peter, Begrow, Frank, Hanske, Gabriela, Justus, Isabel, Mat'us, Marek, ...

Objective: The aim of the present study was to assess the effects of A1-adenosine receptor (A1-AR) stimulation in ventricle of A1-adenosine receptor overexpressing mice (transgenic mice, TG)....

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Effects of A3 adenosine receptor activation and gene knock-out in ischemic-reperfused mouse heart (2002)

Harrison, Glenn, Cerniway, Rachael J, Peart, Jason Nigel John, Berr, Stuart S, Ashton, Kevin John, Regan, Sara, ...

Objectives: To characterize effects of A3 adenosine receptor (A3AR) activation and gene knock-out on responses to ischemia-reperfusion in mouse heart. Methods: Perfused hearts from wild-type and A3AR...

Effect of cardiac A1 adenosine receptor overexpression on sarcoplasmic reticulum function (2002)

Zucchi, Riccardo, Cerniway, Rachael J, Ronca-Testoni, Simonetta, Morrison, R.Ray, Ronca, Giovanni, Matherne, G.Paul

Objective: We investigated the effect of A1 adenosine receptor overexpression, which has been reported to increase myocardial tolerance to ischemia-reperfusion injury, on sarcoplasmic reticulum (SR)...

5'-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Garnham, Bronwyn Gaye, Matherne, G Paul

We examined myocardial 52-adenosine monophosphate (52-AMP) catabolism, adenosine salvage and adenosine responses in perfused guinea pig, rat and mouse heart. MV2 increased from 71±8 ¼l O2/min per g...

5'-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Garnham, Bronwyn Gaye, Matherne, G Paul

We examined myocardial 52-adenosine monophosphate (52-AMP) catabolism, adenosine salvage and adenosine responses in perfused guinea pig, rat and mouse heart. MV2 increased from 71±8 ¼l O2/min per g...

5'-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Garnham, Bronwyn Gaye, Matherne, G Paul

We examined myocardial 52-adenosine monophosphate (52-AMP) catabolism, adenosine salvage and adenosine responses in perfused guinea pig, rat and mouse heart. MV2 increased from 71±8 ¼l O2/min per g...

5'-Adenosine monophosphate and adenosine metabolism, and adenosine responses in mouse, rat and guinea pig heart (2001)

Headrick, John Patrick, Peart, Jason Nigel John, Hack, Benjamin Daniel Noel, Garnham, Bronwyn Gaye, Matherne, G Paul

We examined myocardial 52-adenosine monophosphate (52-AMP) catabolism, adenosine salvage and adenosine responses in perfused guinea pig, rat and mouse heart. MV2 increased from 71±8 ¼l O2/min per g...

Transgenic A1 adenosine receptor overexpression increases myocardial resistance to ischemia

Matherne, G. Paul, Linden, Joel, Byford, Anne M., Gauthier, Naomi S., Headrick, John P.

Activation of myocardial A1 adenosine receptors (A1AR) protects the heart from ischemic injury. In this study transgenic mice were created using the cardiac-specific α-myosin heavy chain promoter...

Transgenic A1 adenosine receptor overexpression increases myocardial resistance to ischemia

Matherne, G. Paul, Linden, Joel, Byford, Anne M., Gauthier, Naomi S., Headrick, John P.

Activation of myocardial A1 adenosine receptors (A1AR) protects the heart from ischemic injury. In this study transgenic mice were created using the cardiac-specific α-myosin heavy chain promoter...

Functional studies in atrium overexpressing A1-adenosine receptors

Neumann, Joachim, Vahlensieck, Ute, Boknik, Peter, Linck, Bettina, Lüss, Hartmut, Müller, Frank U, ...

Adenosine and the A1-adenosine receptor agonist R-PIA, exerted a negative inotropic effect in isolated, electrically driven left atria of wild-type mice.In left atria of mice overexpressing the...

Pertussis toxin sensitive and insensitive effects of adenosine and carbachol in murine atria overexpressing A1-adenosine receptors

Neumann, Joachim, Boknik, Peter, Matherne, G Paul, Lankford, Amy, Schmitz, Wilhelm

It was investigated how A1-adenosine receptor overexpression alters the effects of carbachol on force of contraction and beating rate in isolated murine atria. Moreover, the influence of pertussis...

Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression

Headrick, John P, Willems, Laura, Ashton, Kevin J, Holmgren, Kirsten, Peart, Jason, Matherne, G Paul

The genesis of the ischaemia intolerant phenotype in aged myocardium is poorly understood. We tested the hypothesis that impaired adenosine-mediated protection contributes to ischaemic intolerance,...

Cardiovascular magnetic resonance of pulmonary artery growth and ventricular function after Norwood procedure with Sano modification

Lim, D Scott, Peeler, Benjamin B, Matherne, G Paul, Kramer, Christopher M

For hypoplastic left heart syndrome (HLHS), there have been concerns regarding pulmonary artery growth and ventricular dysfunction after first stage surgery consisting of the Norwood procedure...