G. Peter Beardsley

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway (2002)

Marsilje, Thomas H., Labroli, Marc A., Hedrick, Michael P., Jin, Qing, Desharnais, Joel, Baker, Stephen J., ...

The synthesis of 10-formyl-DDACTHF (3) as a potential inhibitor of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide ribonucleotide transformylase (AICAR Tfase) is...

Chemical synthesis of DNA oligomers containing cytosine arabinoside (1988)

Beardsley, G. Peter, Mikita, Thomas, Klaus, Melissa M., Nussbaum, Alexander L.

The solid phase phospite triester synthesis of oligodeaxynucleotides containing cytosine arabinoside (araC) is described. A protected araC phosphor-amadite was prepared for the introduction of araC...

Thymlne glycol lesions terminate chain elongation by DNA polymerase I in vitro (1986)

Clark, James M., Beardsley, G.Peter

Single-strand circular DNA from bacteriopbage H13mp9 was chemically modified with osmium tetroxide to introduce specifically cis-thymine glycol lesions, a major type of DNA damage produced by...

Pharmacologic studies on the dibutyl and γ-monobutyl esters of methotrexate in the rhesus monkey (1982)

Modest, Edward J., Abelson, Herbert T., Rosowsky, Andre, Beardsley, G. Peter, Ensminger, William D., Kufe, Donald W., ...

The pharmacokinetics and metabolism of dibutyl methotrexate (DBMTX) and γ-monobutyl methotrexate (γ-MBMTX) were studied in Rhesus monkeys. When a bolus IV dose of either [ 3 H]DBMTX or [ 3...