Holton, J.L., Lashley, T., Ghiso, J., Braendgaard, H., Vidal, R., Guerin, C., ...
Familial Danish dementia (FDD) is pathologically characterized by widespread cerebral amyloid angiopathy (CAA), parenchymal protein deposits, and neurofibrillary degeneration. FDD is associated with...
Holton, J.L., Ghiso, J., Lashle, T., Rostagno, A., Guerin, C.J., Gibb, G., ...
Familial British dementia (FBD), pathologically characterized by cerebral amyloid angiopathy (CAA), amyloid plaques, and neurofibrillary degeneration, is associated with a stop codon mutation in the...
Epidemic optic neuropathy in primary school children in Dar es Salaam, Tanzania
Bourne, R, Dolin, P, Mtanda, A, Plant, G, Mohamed, A
BACKGROUND—An epidemic of bilateral optic neuropathy is affecting large numbers of people aged between 10 and 40 in Dar es Salaam, the capital city of Tanzania. The disease is characterised by...
Brown, P, Demaerel, P, McNaught, A, Revesz, T, Graham, E, Kendall, B E, ...
Two cases of non-invasive aspergillosis of the nose and paranasal sinuses are described. The first presented with left proptosis and ophthalmoplegia. Imaging and histology showed a maxillary sinus...
Saldanha, G, Hongo, J, Plant, G, Acheson, J, Levy, I, Anand, P
The peptidergic sensory innervation of cranial blood vessels may play an important part in vascular head pain. The neuropeptides calcitonin gene-related peptide (CGRP) and substance P in sensory...
Werring, D., Bullmore, E., Toosy, A., Miller, D., Barker, G., MacManus, D., ...
OBJECTIVES—Recovery to normal or near normal visual acuity is usual after acute demyelinating optic neuritis, despite the frequent persistence of conduction abnormalities as evidenced by the visual...
Brex, P, Miszkiel, K, O'Riordan, J, Plant, G, Moseley, I, Thompson, A, ...
OBJECTIVES—With increasing evidence that permanent tissue damage occurs early in the course of multiple sclerosis, it is important that treatment trials include patients in the earliest stages of...
Measurement of spinal cord area in clinically isolated syndromes suggestive of multiple sclerosis
Brex, P, Leary, S, O'Riordan, J, Miszkiel, K, Plant, G, Thompson, A, ...
Atrophy of the spinal cord is known to occur in multiple sclerosis but the cause and the timing of its onset are not clear. Recent evidence suggests that atrophy may start to occur early in the...
GEORGE, M, ROTHWELL, J., BARKER, R, ZEKI, S, FFYTCHE, D, BALLARD, C, ...
Infundibulohypophysitis in a man presenting with diabetes insipidus and cavernous sinus involvement
Tubridy, N, Saunders, D, Thom, M, Asa, S, Powell, M, Plant, G, ...
Infundibulohypophysitis is an unusual inflammatory condition that affects the infundibulum, the pituitary stalk, and the neurohypophysis and may be part of a range that includes lymphocytic...
Mead, S, Proukakis, C, Wood, N, Crosby, A, Plant, G, Warner, T
Hereditary spastic paraparesis (HSP) is a clinically and genetically heterogeneous neurodegenerative disorder characterised by progressive lower limb spasticity and weakness. Some forms have been...
Dalton, C, Brex, P, Jenkins, R, Fox, N, Miszkiel, K, Crum, W, ...
Background: In patients with clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS), the extent of brain magnetic resonance imaging (MRI) lesion load influences the probability and...
Spinal cord MRI in clinically isolated optic neuritis
Dalton, C, Brex, P, Miszkiel, K, Fernando, K, MacManus, D, Plant, G, ...
Results: Eighty one (70%) patients had brain lesions and 31 (27%) had cord lesions. Cord lesions were seen in 12% with a normal brain MRI, 21% with between one and eight brain lesions, and 45% with...
Corticosteroids do not prevent optic nerve atrophy following optic neuritis
Hickman, S, Kapoor, R, Jones, S, Altmann, D, Plant, G, Miller, D
Axonal degeneration and inflammation in acute optic neuritis
Petzold, A, Rejdak, K, Plant, G
Methods: Eighteen patients with ON and 14 controls were investigated in a longitudinal, prospective study. Plasma phosphorylated neurofilament heavy chain (NfHSMI35; a surrogate marker of axonal...
"Bottom-up" and "top-down" effects on reading saccades: a case study
Upton, N, Hodgson, T, Plant, G, Wise, R, Leff, A
Objective: To investigate the role right foveal/parafoveal sparing plays in reading single words, word arrays, and eye movement patterns in a single case with an incongruous hemianopia.
Twenty four patients who had undergone temporal lobe surgery for epilepsy were assessed to determine (a) whether or not they had developed a visual field defect and (b) if a field defect was present,...
Relapsing intracranial Rosai-Dorfman disease
Petzold, A, Thom, M, Powell, M, Plant, G.
Two patients presenting with recurrent visual impairment due to relapsing intracranial Rosai-Dorfman disease are described. In both patients a preoperative diagnosis of meningioma was made....