In an effort to improve the antiviral potency of ribavirin, several selected derivatives of ribavirin have been prepared. A number of heterocycles and nucleosides in the 1,2,3-triazole,...
Ojwang, J O, Bhattacharya, B K, Marshall, H B, Korba, B E, Revankar, G R, Rando, R F
The nucleoside analog 2,4-diamino-7-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)pyrrolo[2,3-d]pyrimidine (T70080) and several related compounds were evaluated for anti-hepatitis B virus (HBV) activity...
Novel pyrazolo[3,4-d]pyrimidine nucleoside analog with broad-spectrum antiviral activity.
Smee, D F, McKernan, P A, Nord, L D, Willis, R C, Petrie, C R, Riley, T M, ...
A novel nucleoside analog, 4(5H)-oxo-1-beta-D- ribofuranosylpyrazolo[3,4-d]pyrimidine-3-thiocarboxamide (N10169), was evaluated in cell culture and in animals for antiviral activity against DNA and...
Activity of purine analogs against Leishmania tropica within human macrophages in vitro.
Berman, J D, Lee, L S, Robins, R K, Revankar, G R
The activity of purine analogs against Leishmania tropica in human monocyte-derived macrophages in vitro was determined. Formycin B, formycin A, formycin B and A monophosphate, and formycin A...
Lewis, A F, Drach, J C, Fennewald, S M, Huffman, J H, Ptak, R G, Sommadossi, J P, ...
A series of alkyl and alkenyl guanine analogs containing a thiazolo[4,5-d]pyrimidine ring system were prepared by reaction of the appropriate alkyl halide with the sodium salt of the heterocycle. In...
Immunoenhancing properties and antiviral activity of 7-deazaguanosine in mice.
Smee, D F, Alaghamandan, H A, Gilbert, J, Burger, R A, Jin, A, Sharma, B S, ...
The nucleotide analog 7-deazaguanosine has not previously been reported to possess biological (antiviral or antitumor) properties in cell culture or in vivo. Up to 10(5) U of interferon per ml was...
Ghose, A K, Viswanadhan, V N, Sanghvi, Y S, Nord, L D, Willis, R C, Revankar, G R, ...
A rationale for the antitumor activity of 4-methoxy- and 4-amino-8-(beta-D-ribofuranosylamino)pyrimido-[5,4-d]pyrimidine (beta-MRPP and beta-ARPP, respectively) was studied by a molecular modeling...
Durland, R H, Rao, T S, Bodepudi, V, Seth, D M, Jayaraman, K, Revankar, G R
The ability of certain azole substituted oligodeoxy-ribonucleotides to promote antiparallel triple helix formation with duplex targets having CG or TA interruptions in the otherwise homopurine...
Binding of T and T analogs to CG base pairs in antiparallel triplexes.
Durland, R H, Rao, T S, Revankar, G R, Tinsley, J H, Myrick, M A, Seth, D M, ...
The goal of this study was to address antiparallel triplex formation at duplex targets that do not conform to a strict oligopurine.oligopyrimidine motif. We focused on the ability of natural bases...
Kazimierczuk, Z, Revankar, G R, Robins, R K
Direct glycosylation of the sodium salt of 4,6-dichloro- or 4,6-dibromo-2-methylthiopyrrolo[2,3-d]pyrimidine with 2,3,5-tri-O-benzoyl-D-ribofuranosyl bromide gave good yield of the corresponding...
Gupta, P K, Robins, R K, Revankar, G R
A facile synthesis of 7-beta-D-ribofuranosyl-3-deazaguanine (1) and certain 8-substituted derivatives of 1 via the sodium salt glycosylation method has been developed. Glycosylation of the sodium...
Cottam, H B, Revankar, G R, Robins, R K
The glycosylation of 4,6-dichloropyrazolo[3,4-d]pyrimidine and 4-chloro-6-methylthiopyrazolo[3,4-d]pyrimidine via the corresponding trimethylsilyl intermediate and tetra-O-acetyl-beta-D-ribofuranose...
Upadhya, K G, Sanghvi, Y S, Robins, R K, Revankar, G R, Ugarkar, B G
A facile synthesis of 7-amino-5-chloro-3-beta-D-ribofuranosylpyrazolo [4,3-d]pyrimidine (5-chloroformycin A, 6), 7-amino-5-chloro-3-(2-deoxy-beta-D-erythro-pentofuranosyl) pyrazolo [4,3-d]-pyrimidine...
Ojwang, J O, Bhattacharya, B K, Marshall, H B, Korba, B E, Revankar, G R, Rando, R F
The nucleoside analog 2,4-diamino-7-(2-deoxy-2-fluoro-beta-D- arabinofuranosyl)pyrrolo[2,3-d]pyrimidine (T70080) and several related compounds were evaluated for anti-hepatitis B virus (HBV) activity...
Novel pyrazolo[3,4-d]pyrimidine nucleoside analog with broad-spectrum antiviral activity.
Smee, D F, McKernan, P A, Nord, L D, Willis, R C, Petrie, C R, Riley, T M, ...
A novel nucleoside analog, 4(5H)-oxo-1-beta-D- ribofuranosylpyrazolo[3,4-d]pyrimidine-3-thiocarboxamide (N10169), was evaluated in cell culture and in animals for antiviral activity against DNA and...
Activity of purine analogs against Leishmania tropica within human macrophages in vitro.
Berman, J D, Lee, L S, Robins, R K, Revankar, G R
The activity of purine analogs against Leishmania tropica in human monocyte-derived macrophages in vitro was determined. Formycin B, formycin A, formycin B and A monophosphate, and formycin A...
Lewis, A F, Drach, J C, Fennewald, S M, Huffman, J H, Ptak, R G, Sommadossi, J P, ...
A series of alkyl and alkenyl guanine analogs containing a thiazolo[4,5-d]pyrimidine ring system were prepared by reaction of the appropriate alkyl halide with the sodium salt of the heterocycle. In...
Immunoenhancing properties and antiviral activity of 7-deazaguanosine in mice.
Smee, D F, Alaghamandan, H A, Gilbert, J, Burger, R A, Jin, A, Sharma, B S, ...
The nucleotide analog 7-deazaguanosine has not previously been reported to possess biological (antiviral or antitumor) properties in cell culture or in vivo. Up to 10(5) U of interferon per ml was...
Ghose, A K, Viswanadhan, V N, Sanghvi, Y S, Nord, L D, Willis, R C, Revankar, G R, ...
A rationale for the antitumor activity of 4-methoxy- and 4-amino-8-(beta-D-ribofuranosylamino)pyrimido-[5,4-d]pyrimidine (beta-MRPP and beta-ARPP, respectively) was studied by a molecular modeling...
Durland, R H, Rao, T S, Bodepudi, V, Seth, D M, Jayaraman, K, Revankar, G R
The ability of certain azole substituted oligodeoxy-ribonucleotides to promote antiparallel triple helix formation with duplex targets having CG or TA interruptions in the otherwise homopurine...
Binding of T and T analogs to CG base pairs in antiparallel triplexes.
Durland, R H, Rao, T S, Revankar, G R, Tinsley, J H, Myrick, M A, Seth, D M, ...
The goal of this study was to address antiparallel triplex formation at duplex targets that do not conform to a strict oligopurine.oligopyrimidine motif. We focused on the ability of natural bases...
Kazimierczuk, Z, Revankar, G R, Robins, R K
Direct glycosylation of the sodium salt of 4,6-dichloro- or 4,6-dibromo-2-methylthiopyrrolo[2,3-d]pyrimidine with 2,3,5-tri-O-benzoyl-D-ribofuranosyl bromide gave good yield of the corresponding...
Gupta, P K, Robins, R K, Revankar, G R
A facile synthesis of 7-beta-D-ribofuranosyl-3-deazaguanine (1) and certain 8-substituted derivatives of 1 via the sodium salt glycosylation method has been developed. Glycosylation of the sodium...
Cottam, H B, Revankar, G R, Robins, R K
The glycosylation of 4,6-dichloropyrazolo[3,4-d]pyrimidine and 4-chloro-6-methylthiopyrazolo[3,4-d]pyrimidine via the corresponding trimethylsilyl intermediate and tetra-O-acetyl-beta-D-ribofuranose...
Upadhya, K G, Sanghvi, Y S, Robins, R K, Revankar, G R, Ugarkar, B G
A facile synthesis of 7-amino-5-chloro-3-beta-D-ribofuranosylpyrazolo [4,3-d]pyrimidine (5-chloroformycin A, 6), 7-amino-5-chloro-3-(2-deoxy-beta-D-erythro-pentofuranosyl) pyrazolo [4,3-d]-pyrimidine...