Scientific Commons: G. R. Siggins

Acamprosate enhances N-Methyl-D-Aspartate Receptor-mediated neurotransmission but inhibits presynaptic GABAB receptors in nucleus accumbens neurons. (1998)

Berton, F., Francesconi, W. G., Madamba, S. G., Zieglgänsberger, W., Siggins, G. R.

Acamprosate (Calcium Acetylhomotaurinate) enhances the N-Methyl-D-Aspartate component of excitatory neurotransmission in rat hippocampal CA1 neurons in vitro (1996)

Madamba, S. G., Schweitzer, P., Zieglgänsberger, W., Siggins, G. R.

Actions of acamprosate on neurons of the central nervous system (1996)

Zieglgänsberger, W., Hauser, C., Wetzel, C., Putzke, J., Siggins, G. R., Spanagel, R.

Low ethanol concentrations enhance GABAergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of GABAB receptors.

Wan, F J, Berton, F, Madamba, S G, Francesconi, W, Siggins, G R

Despite considerable evidence that ethanol can enhance chloride flux through the gamma-aminobutyric acid type A (GABA/A/) receptor-channel complex in several central neuron types, the effect of...

Somatostatin depresses excitability in neurons of the solitary tract complex through hyperpolarization and augmentation of IM, a non-inactivating voltage-dependent outward current blocked by muscarinic agonists.

Jacquin, T, Champagnat, J, Madamba, S, Denavit-Saubié, M, Siggins, G R

The synaptic function of somatostatin-containing fibers in the nervous system is controversial. Therefore, we used a slice preparation of the rat brain stem to test the electrophysiological effects...

Morphine and opioid peptides reduce inhibitory synaptic potentials in hippocampal pyramidal cells in vitro without alteration of membrane potential.

Siggins, G R, Zieglgänsberger, W

We used intracellular recording in the hippocampal slice in vitro to characterize further the mechanisms behind the unusual excitatory action of opiates and opioid peptides on hippocampal pyramidal...

Iontophoresis of Li+ antagonizes noradrenergic synaptic inhibition of rat cerebellar Purkinje cells.

Siggins, G R, Henriksen, S J, Bloom, F

Li salts provide effective therapy for manic-depressive psychosis, but the site and mechanism of this effect are not known. We have tested the ability of Li, applied by microiontophoresis, to modify...

Somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex.

Mancillas, J R, Siggins, G R, Bloom, F E

The neuronal effects of somatostatin-14 (SS-14) and its influence on responses to acetylcholine (AcCho) were studied in vivo in the rat parietal cortex and dorsal hippocampus, using single-unit...

Vasoactive intestinal polypeptide acts synergistically with norepinephrine to depress spontaneous discharge rate in cerebral cortical neurons.

Ferron, A, Siggins, G R, Bloom, F E

Cortical neurons are densely innervated by noradrenergic fibers and by intrinsic cortical interneurons containing vasoactive intestinal polypeptide (VIP). Biochemically, VIP and norepinephrine (NE)...

Chronic treatment with lithium or desipramine alters discharge frequency and norepinephrine responsiveness of cerebellar Purkinje cells.

Siggins, G R, Schultz, J E

Cerebellar Purkinje cells were studied by electrophysiological techniques in rats treated chronically with either desipramine (DMI) or lithium chloride given intragastrically. A striking decrement...

Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.

Nicoll, R A, Siggins, G R, Ling, N, Bloom, F E, Guillemin, R

The brain peptides alpha- and beta-endorphin, leucine- and methionine-enkephalin, as well as the opiate normorphine, have been evaluated by microiontophoresis for their effects on neuronal activity...