Scientific Commons: G. Superti-Furga

Nature Biotechnology, 25(2007) S.894-98

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling (2006)

Angrand, P. O., Segura, I., Volkel, P., Ghidelli, S., Terry, R., Brajenovic, M., ...

Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl. (2005)

Hantschel, O., Wiesner, S., Guettler, T., Mackereth, C. D., Remsing Rix, L. L., Mikes, Z., ...

Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin (1989)

Barberis, A, Superti-Furga, G, Vitelli, L, Kemler, I, Busslinger, M

Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins.

Superti-Furga, G, Bergers, G, Picard, D, Busslinger, M

The protooncogene c-fos has been implicated in the control of proliferation and transformation of fibroblasts, and its protein product is an essential component of transcription factor AP1. The...

The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway.

Toda, T, Dhut, S, Superti-Furga, G, Gotoh, Y, Nishida, E, Sugiura, R, ...

We have isolated a gene, pmk1+, a third mitogen-activated protein kinase (MAPK) gene homolog from the fission yeast Schizosaccharomyces pombe. The predicted amino acid sequence shows the most...

The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins.

Mandl, B, Brandt, W F, Superti-Furga, G, Graninger, P G, Birnstiel, M L, Busslinger, M

The cleavage-stage (CS) histones of the sea urchin are known to be maternally expressed in the egg, have been implicated in chromatin remodeling of the male pronucleus following fertilization, and...

The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein.

Mantovani, R, Superti-Furga, G, Gilman, J, Ottolenghi, S

Non-deletion Hereditary Persistence of Fetal Hemoglobin (HPFH) is characterized by great elevation of the synthesis, in adult age, of fetal hemoglobin (HbF), of either the A gamma or G gamma type....

The testis-specific octamer-binding protein of the sea urchin has a molecular weight of 85 kDa.

Barberis, A, Superti-Furga, G, Busslinger, M

Mutational analysis of the Src SH3 domain: the same residues of the ligand binding surface are important for intra- and intermolecular interactions.

Erpel, T, Superti-Furga, G, Courtneidge, S A

The protein tyrosine kinase c-Src is negatively regulated by phosphorylation of Tyr527 in its C-terminal tail. The repressed state is achieved through intramolecular interactions involving the...

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

Superti-Furga, G, Fumagalli, S, Koegl, M, Courtneidge, S A, Draetta, G

The protein tyrosine kinase c-Src is negatively regulated by phosphorylation of Tyr527 in its carboxy-terminal tail. A kinase that phosphorylates Tyr527, called Csk, has recently been identified. We...

The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene.

Superti-Furga, G, Barberis, A, Schaffner, G, Busslinger, M

The Greek form of hereditary persistence of fetal hemoglobin (HPFH) is associated with a point mutation immediately upstream of the distal of the two CCAAT elements of the A gamma-globin gene. Three...

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

Migliaccio, E, Mele, S, Salcini, A E, Pelicci, G, Lai, K M, Superti-Furga, G, ...

Shc proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to Ras. The p46shc and p52shc isoforms share a C-terminal SH2 domain, a proline-...

The role of the linker between the SH2 domain and catalytic domain in the regulation and function of Src.

Gonfloni, S, Williams, J C, Hattula, K, Weijland, A, Wierenga, R K, Superti-Furga, G

The crystal structures of the regulated Src and Hck tyrosine kinases show intramolecular interactions between the phosphorylated tail and the SH2 domain as well as between the SH3 domain, the...

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation.

Mason, C S, Springer, C J, Cooper, R G, Superti-Furga, G, Marshall, C J, Marais, R

The Raf family of serine/threonine protein kinases couple growth factor receptor stimulation to mitogen activated protein kinase activation, but their own regulation is poorly understood. Using...