Hwang, J H, Perseghin, G, Rothman, D L, Cline, G W, Magnusson, I, Petersen, K F, ...
Hepatic glycogen concentration was measured in six subjects with insulin-dependent diabetes mellitus (IDDM) and nine weight-matched control subjects using 13C nuclear magnetic resonance spectroscopy...
Cline, G W, Rothman, D L, Magnusson, I, Katz, L D, Shulman, G I
To determine the effect of insulin-dependent diabetes mellitus (IDDM) on rates and pathways of hepatic glycogen synthesis, as well as flux through hepatic pyruvate dehydrogenase, we used 13C-nuclear...
Taylor, R, Magnusson, I, Rothman, D L, Cline, G W, Caumo, A, Cobelli, C, ...
Despite extensive recent studies, understanding of the normal postprandial processes underlying immediate storage of substrate and maintenance of glucose homeostasis in humans after a mixed meal has...
Roden, M, Perseghin, G, Petersen, K F, Hwang, J H, Cline, G W, Gerow, K, ...
To determine the respective roles of insulin and glucagon for hepatic glycogen synthesis and turnover, hyperglycemic clamps were performed with somatostatin [0.1 micrograms/(kg.min)] in healthy young...
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M, Price, T B, Perseghin, G, Petersen, K F, Rothman, D L, Cline, G W, ...
To examine the mechanism by which lipids cause insulin resistance in humans, skeletal muscle glycogen and glucose-6-phosphate concentrations were measured every 15 min by simultaneous 13C and 31P...
Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.
Velho, G, Petersen, K F, Perseghin, G, Hwang, J H, Rothman, D L, Pueyo, M E, ...
All glucokinase gene mutations identified to date have been localized to exons that are common to the pancreatic and hepatic isoforms of the enzyme. While impaired insulin secretion has been observed...
Cline, G W, Magnusson, I, Rothman, D L, Petersen, K F, Laurent, D, Shulman, G I
To determine the mechanism of impaired insulin-stimulated muscle glycogen metabolism in patients with poorly controlled insulin-dependent diabetes mellitus (IDDM), we used 13C-NMR spectroscopy to...
Russell, R R, Cline, G W, Guthrie, P H, Goodwin, G W, Shulman, G I, Taegtmeyer, H
Myocardial glucose use is regulated by competing substrates and hormonal influences. However, the interactions of these effectors on the metabolism of exogenous glucose and glucose derived from...
Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans.
Petersen, K F, Laurent, D, Rothman, D L, Cline, G W, Shulman, G I
13C NMR spectroscopy was used to assess flux rates of hepatic glycogen synthase and phosphorylase in overnight-fasted subjects under one of four hypoglucagonemic conditions: protocol I, hyperglycemic...
Hwang, J H, Perseghin, G, Rothman, D L, Cline, G W, Magnusson, I, Petersen, K F, ...
Hepatic glycogen concentration was measured in six subjects with insulin-dependent diabetes mellitus (IDDM) and nine weight-matched control subjects using 13C nuclear magnetic resonance spectroscopy...
Cline, G W, Rothman, D L, Magnusson, I, Katz, L D, Shulman, G I
To determine the effect of insulin-dependent diabetes mellitus (IDDM) on rates and pathways of hepatic glycogen synthesis, as well as flux through hepatic pyruvate dehydrogenase, we used 13C-nuclear...
Taylor, R, Magnusson, I, Rothman, D L, Cline, G W, Caumo, A, Cobelli, C, ...
Despite extensive recent studies, understanding of the normal postprandial processes underlying immediate storage of substrate and maintenance of glucose homeostasis in humans after a mixed meal has...
Roden, M, Perseghin, G, Petersen, K F, Hwang, J H, Cline, G W, Gerow, K, ...
To determine the respective roles of insulin and glucagon for hepatic glycogen synthesis and turnover, hyperglycemic clamps were performed with somatostatin [0.1 micrograms/(kg.min)] in healthy young...
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M, Price, T B, Perseghin, G, Petersen, K F, Rothman, D L, Cline, G W, ...
To examine the mechanism by which lipids cause insulin resistance in humans, skeletal muscle glycogen and glucose-6-phosphate concentrations were measured every 15 min by simultaneous 13C and 31P...
Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.
Velho, G, Petersen, K F, Perseghin, G, Hwang, J H, Rothman, D L, Pueyo, M E, ...
All glucokinase gene mutations identified to date have been localized to exons that are common to the pancreatic and hepatic isoforms of the enzyme. While impaired insulin secretion has been observed...
Cline, G W, Magnusson, I, Rothman, D L, Petersen, K F, Laurent, D, Shulman, G I
To determine the mechanism of impaired insulin-stimulated muscle glycogen metabolism in patients with poorly controlled insulin-dependent diabetes mellitus (IDDM), we used 13C-NMR spectroscopy to...
Russell, R R, Cline, G W, Guthrie, P H, Goodwin, G W, Shulman, G I, Taegtmeyer, H
Myocardial glucose use is regulated by competing substrates and hormonal influences. However, the interactions of these effectors on the metabolism of exogenous glucose and glucose derived from...
Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans.
Petersen, K F, Laurent, D, Rothman, D L, Cline, G W, Shulman, G I
13C NMR spectroscopy was used to assess flux rates of hepatic glycogen synthase and phosphorylase in overnight-fasted subjects under one of four hypoglucagonemic conditions: protocol I, hyperglycemic...