Rogers, J., Schoepp, R.J., Schröder, O., Clements, T.L., Holland, T.F., Li, J.Q., ...
Using a comprehensive set of discovery and optimization tools, antibodies were produced with the ability to neutralize SARS coronavirus (SARS-CoV) infection in Vero E6 cells and in animal models....
Woodnutt, G., Berry, V., Kernutt, I., Mizen, L.
The distribution of amoxycillin, ticarcillin and clavulanic acid into lymph collected from the right lymphatic duct of rabbits was examined after intravenous administration. The compounds were...
Bactericidal and morphological effects of amoxicillin on Helicobacter pylori.
Berry, V, Jennings, K, Woodnutt, G
The growth kinetics of Helicobacter pylori after it has been exposed to amoxicillin have been investigated in conjunction with studies of cell morphology. A potent bactericidal effect was observed at...
Effect of protein binding on penetration of beta-lactams into rabbit peripheral lymph.
Woodnutt, G, Berry, V, Mizen, L
The relevance of protein binding to penetration of beta-lactams into body fluids was investigated by examining the distribution of amoxicillin, ceftriaxone, clavulanic acid, temocillin, and...
Mizen, L, Woodnutt, G, Kernutt, I, Catherall, E J
The penetration into cerebrospinal fluid (CSF) and efficacy of ticarcillin-clavulanic acid, ticarcillin alone, and ceftazidime were compared in rabbits with experimentally induced Klebsiella...
Pharmacokinetics and distribution of ticarcillin-clavulanic acid (Timentin) in experimental animals.
Woodnutt, G, Kernutt, I, Mizen, L
The pharmacokinetics and distribution of ticarcillin and clavulanic acid were studied in rats and rabbits after intravenous coadministration of the compounds. The elimination half-lives for...
Woodnutt, G, Catherall, E J, Kernutt, I, Mizen, L
An infusion system was developed to simulate in the plasma of rabbits the concentrations of temocillin in human serum measured after administration of a 2-g intravenous bolus dose. The efficacy of...
Woodnutt, G, Berry, V, Mizen, L
Studies were performed to determine the effects of BRL 42715, a potent beta-lactamase inhibitor, on the activity of cefazolin and piperacillin against experimental intraperitoneal infections caused...
Rabbit liver acetyl-CoA synthetase.
Acetyl-CoA synthetase (EC 6.2.1.1) was assayed in subcellular fractions of rabbit liver homogenates. The activity was located almost exclusively in the cytosol. There was no decrease in activity when...
Bactericidal and morphological effects of amoxicillin on Helicobacter pylori.
Berry, V, Jennings, K, Woodnutt, G
The growth kinetics of Helicobacter pylori after it has been exposed to amoxicillin have been investigated in conjunction with studies of cell morphology. A potent bactericidal effect was observed at...
Effect of protein binding on penetration of beta-lactams into rabbit peripheral lymph.
Woodnutt, G, Berry, V, Mizen, L
The relevance of protein binding to penetration of beta-lactams into body fluids was investigated by examining the distribution of amoxicillin, ceftriaxone, clavulanic acid, temocillin, and...
Mizen, L, Woodnutt, G, Kernutt, I, Catherall, E J
The penetration into cerebrospinal fluid (CSF) and efficacy of ticarcillin-clavulanic acid, ticarcillin alone, and ceftazidime were compared in rabbits with experimentally induced Klebsiella...
Pharmacokinetics and distribution of ticarcillin-clavulanic acid (Timentin) in experimental animals.
Woodnutt, G, Kernutt, I, Mizen, L
The pharmacokinetics and distribution of ticarcillin and clavulanic acid were studied in rats and rabbits after intravenous coadministration of the compounds. The elimination half-lives for...
Woodnutt, G, Catherall, E J, Kernutt, I, Mizen, L
An infusion system was developed to simulate in the plasma of rabbits the concentrations of temocillin in human serum measured after administration of a 2-g intravenous bolus dose. The efficacy of...
Woodnutt, G, Berry, V, Mizen, L
Studies were performed to determine the effects of BRL 42715, a potent beta-lactamase inhibitor, on the activity of cefazolin and piperacillin against experimental intraperitoneal infections caused...
Rabbit liver acetyl-CoA synthetase.
Acetyl-CoA synthetase (EC 6.2.1.1) was assayed in subcellular fractions of rabbit liver homogenates. The activity was located almost exclusively in the cytosol. There was no decrease in activity when...
Rapid discovery and optimization of therapeutic antibodies against emerging infectious diseases
Rogers, J., Schoepp, R.J., Schröder, O., Clements, T.L., Holland, T.F., Li, J.Q., ...
Using a comprehensive set of discovery and optimization tools, antibodies were produced with the ability to neutralize SARS coronavirus (SARS-CoV) infection in Vero E6 cells and in animal models....