The development of anti-diphtheria serotherapy at the Institut Pasteur immediately follows the crisis known as the Pasteur-Koch debate. Research on diphtheria in Paris is indicative of the importance...
MHC and MHC-related proteins as pleiotropic signal molecules (2008)
David M. Ojcius, Christiane Delarbre, Philippe Kourilsky, Gabriel Gachelin
ABSTRACT Class I molecules of the major histocompatibility complex (MHC) have been studied primarily for their role in presenting peptide antigens to conventional T lymphocytes. An increasing body of...
De l’animal expérimental au modèle en recherche biomédicale. (2008)
Depuis le début de l’expérimentation en biologie, les animaux sont utilisés pour étudier des phénomènes inabordables chez l’homme. Le développement depuis 1985, de procédures...
Le retour de la normalisation hygiéniste ? (2008)
Ce débat porte sur l’application au 1er janvier 2008 du décret d’interdiction de fumer dans les lieux publics. En France, elle n’a provoqué que peu de protestations, des propos désabusés...
De lanimal expérimental au modèle en recherche biomédicale. (2008)
Depuis le début de lexpérimentation en biologie, les animaux sont utilisés pour étudier des phénomènes inabordables chez lhomme. Le développement depuis 1985, de procédures...
Le retour de la normalisation hygiéniste ? (2008)
Ce débat porte sur lapplication au 1er janvier 2008 du décret dinterdiction de fumer dans les lieux publics. En France, elle na provoqué que peu de protestations, des propos désabusés des...
Créationnisme contre théorie de l’évolution : Vraie controverse ou faux débat ? (2007)
Il est de la liberté de chacun de tenir le créationnisme pour la vérité. Le point important commun aux tentatives créationnistes est de tenter de donner à une explication religieuse, le même...
The building up of a culture of standardization at the Institut Pasteur, 1885-1900 (2007)
The present paper thus primarily deals with the manner a “culture of quantification and standardization” has been introduced at the Institut Pasteur or, more precisely, has been imposed by Emile...
Créationnisme contre théorie de lévolution : Vraie controverse ou faux débat ? (2007)
Il est de la liberté de chacun de tenir le créationnisme pour la vérité. Le point important commun aux tentatives créationnistes est de tenter de donner à une explication religieuse, le même...
The building up of a culture of standardization at the Institut Pasteur, 1885-1900 (2007)
The present paper thus primarily deals with the manner a culture of quantification and standardization has been introduced at the Institut Pasteur or, more precisely, has been imposed by Emile...
Molecular biology, a widely used expression for a changeable meaning (2006)
On my side, I believe that I first encountered the expression “molecular biology” at the very beginning of my thesis work, in October 1964, when seeing an issue of the Journal of Molecular...
Molecular biology, a widely used expression for a changeable meaning (2006)
On my side, I believe that I first encountered the expression molecular biology at the very beginning of my thesis work, in October 1964, when seeing an issue of the Journal of Molecular Biology,...
Delarbre, Christiane, Escriva, Hector, Gallut, Cyril, Barriel, Véronique, Kourilsky, Philippe, Janvier, Philippe, ...
There are two competing theories about the interrelationships of craniates: the cyclostome theory assumes that lampreys and hagfishes are a clade, the cyclostomes, whose sister group is the jawed...
Conserved structural motifs among mammalian junB genes (1992)
Kawakami, Zenji, Kitabayashi, Issay, Matsuoka, Tatsuhiko, Gachelin, Gabriel, Yokoyama, Kazushige
E1A dependent up-regulation of c-jun/AP-1 activity (1991)
Kitabayashi, Issay, Chiu, Robert, Gachelin, Gabriel, Yokoyama, Kazushige
E1A, the early region 1A transcription unit of human adenovirus, exhibits multiple functions that regulate the expression of some cellular genes and promote cell growth and division. We found that...
Nucleotide sequence of rat c-jun protooncogene (1990)
Kitabayashi, Issay, Saka, Fujiko, Gachelin, Gabriel, Yokoyama, Kazushige
Comparison of the promoter regions of H-2Kb and H-2Kbm1 class I MHC genes (1990)
Ozawa, Kazuo, Saka, Fujiko, Kitabayashi, Issay, Lmai, Takashi, Soeda, Eiichi, Israel, Alain, ...
The 2.0 kb-long nucleotide sequences of the promoter regions of two closely related class I genes of the mouse major histocompatibility complex (H-2Kb and H-2Kbm1) have been determined and compared....
MURAMATSU, Hisako, ISHIHARA, Hideko, MIYAUCHI, Teruo, GACHELIN, Gabriel, FUJISAKI, Tadashi, TEJIMA, Setsuzo, ...
The high-molecular-weight glycopeptides characteristic of early embryonic cells were isolated from F9 embryonal carcinoma cells grown in vitro and also from the cells grown in vivo as subcutaneous...
Lalanne, Jean-Louis, Delarbre, Christiane, Gachelin, Gabriel, Kourilsky, Philippe
We have isolated a cDNA clone carrying a 1560 bp long insert which contains the entire coding and 3′ untranslated regions of an H-2Kd mouse histocompatibility antigen. Its sequence and overal...
High-Mannose Glycopeptides from Embryonal Carcinoma Cells (1980)
MURAMATSU, Takashi, GACHELIN, Gabriel, JACOB, Francois
Endo-β-N-acetylglucosaminidase H released four major oligosaccharides from high-mannose glycopeptides prepared from embryonal carcinoma cells. The oligosaccharides were indistinguishable from...
Perfettini, Jean-Luc, Darville, Toni, Gachelin, Gabriel, Souque, Philippe, Huerre, Michel, Dautry-Varsat, Alice, ...
The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to...
A cDNA clone containing the entire coding sequence of a mouse H-2Kd histocompatibility antigen
Lalanne, Jean-Louis, Delarbre, Christiane, Gachelin, Gabriel, Kourilsky, Philippe
We have isolated a cDNA clone carrying a 1560 bp long insert which contains the entire coding and 3′ untranslated regions of an H-2Kd mouse histocompatibility antigen. Its sequence and overal...
Presence of a Mouse Embryonic Antigen on Human Spermatozoa
Buc-Caron, Marie-Hélène, Gachelin, Gabriel, Hofnung, Maurice, Jacob, François
A cell-surface antigen common to mouse primitive teratocarcinoma cells, morulae, and spermatozoa and specified by the +t12 allele at the T-locus of the mouse has been shown by serological methods to...
Perfettini, Jean-Luc, Darville, Toni, Gachelin, Gabriel, Souque, Philippe, Huerre, Michel, Dautry-Varsat, Alice, ...
The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to...
A cDNA clone containing the entire coding sequence of a mouse H-2Kd histocompatibility antigen
Lalanne, Jean-Louis, Delarbre, Christiane, Gachelin, Gabriel, Kourilsky, Philippe
We have isolated a cDNA clone carrying a 1560 bp long insert which contains the entire coding and 3′ untranslated regions of an H-2Kd mouse histocompatibility antigen. Its sequence and overal...
Presence of a Mouse Embryonic Antigen on Human Spermatozoa
Buc-Caron, Marie-Hélène, Gachelin, Gabriel, Hofnung, Maurice, Jacob, François
A cell-surface antigen common to mouse primitive teratocarcinoma cells, morulae, and spermatozoa and specified by the +t12 allele at the T-locus of the mouse has been shown by serological methods to...
Mempel, Martin, Flageul, Beatrice, Suarez, Felipe, Ronet, Catherine, Dubertret, Louis, Kourilsky, Philippe, ...
The T-cell-reactive (eg, tuberculoid and reversal) forms of leprosy represent a well-defined granulomatous reaction pattern against an invading pathogen. The immune response in cutaneous sarcoidosis...