Gabriel S. Weatherhead

New methods for catalytic asymmetric ring-closing and ring-opening/ring-closing olefin metathesis: Applications towards the asymmetric synthesis of africanol (2004)

Weatherhead, Gabriel S

Chapter 1 . A brief introduction to asymmetric catalytic desymmetrization is highlighted, with a focus on methods utilized for directed total synthesis. The development of the first asymmetric...

Mo-catalyzed asymmetric olefin metathesis in target-oriented synthesis: Enantioselective synthesis of (+)-africanol

Weatherhead, Gabriel S., Cortez, G. A., Schrock, Richard R., Hoveyda, Amir H.

Catalytic asymmetric ring-opening metathesis (AROM) provides an efficient method for the synthesis of a variety of optically enriched small organic molecules that cannot be easily prepared by...

Mo-catalyzed asymmetric olefin metathesis in target-oriented synthesis: Enantioselective synthesis of (+)-africanol

Weatherhead, Gabriel S., Cortez, G. A., Schrock, Richard R., Hoveyda, Amir H.

Catalytic asymmetric ring-opening metathesis (AROM) provides an efficient method for the synthesis of a variety of optically enriched small organic molecules that cannot be easily prepared by...

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Manfredi, Mark G., Ecsedy, Jeffrey A., Meetze, Kristan A., Balani, Suresh K., Burenkova, Olga, Chen, Wei, ...

Increased Aurora A expression occurs in a variety of human cancers and induces chromosomal abnormalities during mitosis associated with tumor initiation and progression. MLN8054 is a selective...