Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions (2009)
Sos, Martin L., Michel, Kathrin, Zander, Thomas, Weiss, Jonathan, Frommolt, Peter, Peifer, Martin, ...
Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. (2009)
Sos, Martin L., Michel, Kathrin, Zander, Thomas, Weiss, Jonathan, Frommolt, Peter, Peifer, Martin, ...
Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. However, no tools...
Somatic mutations affect key pathways in lung adenocarcinoma (2008)
Ding, Li, Getz, Gad, Wheeler, David A., Mardis, Elaine R., McLellan, Michael D., Cibulskis, Kristian, ...
Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well- classified primary tumours. Here we report the results of a collaborative...
BIOINFORMATICS APPLICATIONS NOTE Gene expression Comparative gene marker selection suite (2008)
Joshua Gould, Gad Getz, Stefano Monti, Michael Reich, Jill P. Mesirov
Motivation: An important step in analyzing expression profiles from microarray data is to identify genes that can discriminate between distinct classes of samples. Many statistical approaches for...
Department of Physics of Complex Systems, (2008)
Libi Hertzberg, Or Zuk, Gad Getz, Eytan Domany
A central issue in molecular biology is understanding the regulatory mechanisms that control gene expression. The availability of whole genome sequences opens the way for computational methods to...
Uri Einav, Yuval Tabach, Gad Getz, Assif Yitzhaky, Ugur Ozbek, Ninette Amariglio, ...
Gene expression analysis reveals a strong signature of an interferon-induced pathway in childhood lymphoblastic leukemia as well as in breast and
Modeling genomic diversity and tumor dependency in malignant melanoma (2008)
Lin, William M., Baker, Alissa C., Beroukhim, Rameen, Winckler, Wendy, Feng, Whei, Marmion, Jennifer M., ...
Somatic mutations affect key pathways in lung adenocarcinoma (2008)
Ding, Li, Getz, Gad, Wheeler, David A., Mardis, Elaine R., McLellan, Michael D., Cibulskis, Kristian, ...
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
Somatic alterations in cellular DNA underlie almost all human cancers(1). The prospect of targeted therapies(2) and the development of high-resolution, genome-wide approaches(3-8) are now spurring...
Gad Getz, Michele Vendruscolo, Eytan Domany, Eytan Domany
Background: Currently, each week about 50 new protein structures are made available in public databases. The attention is focused on developing automatic methods of classification. The work of...
Ninette Amariglio, Gideon Rechavi, Jasmine Jakob-hirsch, Itai Kela, Naftali Kaminski, Gad Getz, ...
microarrays identi®cation of primary and secondary target genes
Ninette Amariglio, Gideon Rechavi, Jasmine Jakob-hirsch, Itai Kela, Naftali Kaminski, Gad Getz, ...
microarrays identification of primary and secondary target
Francisco J Quintana, Gad Getz, Guy Hed, Eytan Domany, Irun R Cohen
analysis of human autoantibody reactivities in health and in type 1 diabetes
Characterizing the cancer genome in lung adenocarcinoma (2007)
Weir, Barbara A., Woo, Michele S., Getz, Gad, Perner, Sven, Ding, Li, Beroukhim, Rameen, ...
Holger Höfling, Gad Getz, Robert Tibshirani
Identifying genes that are involved in the development of cancer has been a very important research goal. One approach tries to identify genes in tumors that have an increased mutation rate....
Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H Y, Feng, Whei L, Debiasi, Ralph M, ...
BACKGROUND: Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...
Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H Y, Feng, Whei L, Debiasi, Ralph M, ...
Background Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...
Jeffrey C. Lee, Igor Vivanco, Rameen Beroukhim, Whei L. Feng, Ralph M. DeBiasi, ...
BackgroundProtein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory...
Semi-Supervised Learning -- A Statistical Physics Approach (2006)
Getz, Gad, Shental, Noam, Domany, Eytan
We present a novel approach to semi-supervised learning which is based on statistical physics. Most of the former work in the field of semi-supervised learning classifies the points by minimizing a...
EGFR activation in glioblastoma through novel missense mutations in the extracellular domain (2006)
Lee, Jeffrey C., Huang, Julie H.Y., Beroukhim, Rameen, Feng, Whei L., DeBiasi, R.M., King, J.C., ...
Comparative gene marker selection suite (2006)
Gould, Joshua, Getz, Gad, Monti, Stefano, Reich, Michael, Mesirov, Jill P.
Motivation: An important step in analyzing expression profiles from microarray data is to identify genes that can discriminate between distinct classes of samples. Many statistical approaches for...
Einav, Uri, Tabach, Yuval, Getz, Gad, Yitzhaky, Assif, Ozbek, Ugur, Amariglio, Ninette, ...
On the basis of epidemiological studies, infection was suggested to play a role in the etiology of human cancer. While for some cancers such a role was indeed demonstrated, there is no direct...
Finding Motifs in Promoter Regions (2005)
Libi Hertzberg, Or Zuk, Gad Getz, Eytan Domany
A central issue in molecular biology is understanding the regulatory mechanisms that control gene expression. The availability of whole genome sequences opens the way for computational methods to...
Outcome signature genes in breast cancer: is there a unique set? (2005)
Ein-Dor, Liat, Kela, Itai, Getz, Gad, Givol, David, Domany, Eytan
Motivation: Predicting the metastatic potential of primary malignant tissues has direct bearing on the choice of therapy. Several microarray studies yielded gene sets whose expression profiles...
Design Principle of Gene Expression Used by Human Stem Cells; Implication for Pluripotency (2004)
Golan-Mashiach, Michal, Dazard, Jean-Eudes, Gerecht-Nir, Sharon, Amariglio, Ninette, Fisher, Tamar, Jacob-Hirsch, Jasmine, ...
Human embryonic stem cells (ESC) are undifferentiated and are endowed with the capacities of self renewal and pluripotential differentiation. Adult stem cells renew their own tissue, but whether they...
FSSP to SCOP and CATH (F2CS) Prediction Server (2004)
Getz, Gad, Starovolsky, Alina, Domany, Eytan
Summary: The F2CS server provides access to the software, F2CS2.00, that implements an automated prediction method of SCOP and CATH classifications of proteins, based on their FSSP Z-scores (Getz et...
Outcome signature genes in breast cancer: is there a unique set? (2004)
Ein-Dor, Liat, Kela, Itai, Getz, Gad, Givol, David, Domany, Eytan
Motivation: Predicting the metastatic potential of primary malignant tissues has direct bearing on choice of therapy. Several microarray studies yielded gene sets whose expression profiles...
F2CS: FSSP to CATH and SCOP prediction server (2004)
Getz, Gad, Starovolsky, Alina, Domany, Eytan
Summary: The F2CS server provides access to the software, F2CS2.00, which implements an automated prediction method of SCOP and CATH classifications of proteins, based on their FSSP Z-scores....
FSSP to SCOP and CATH (F2CS) prediction server (2004)
Getz, Gad, Starovolsky, Alina, Domany, Eytan
Summary: The F2CS server provides access to the software, F2CS2.00, that implements an automated prediction method of SCOP and CATH classifications of proteins, based on their FSSP Z-scores (Getz et...
Outcome signature genes in breast cancer: is there a unique set? (2004)
Ein-Dor, Liat, Kela, Itai, Getz, Gad, Givol, David, Domany, Eytan
Motivation: Predicting the metastatic potential of primary malignant tissues has direct bearing on choice of therapy. Several microarray studies yielded gene sets whose expression profiles...
FSSP to SCOP and CATH (F2CS) prediction server (2004)
Getz, Gad, Starovolsky, Alina, Domany, Eytan
Summary: The F2CS server provides access to the software, F2CS2.00, that implements an automated prediction method of SCOP and CATH classifications of proteins, based on their FSSP Z-scores (Getz et...
Outcome signature genes in breast cancer: is there a unique set? (2004)
Ein-Dor, Liat, Kela, Itai, Getz, Gad, Givol, David, Domany, Eytan
Motivation: Predicting the metastatic potential of primary malignant tissues has direct bearing on choice of therapy. Several microarray studies yielded gene sets whose expression profiles...
Vol No Pages, Gad Getz, Hilah Gal, Itai Kela, Daniel A. Notterman, Eytan Domany
We present and review coupled two-way clustering, a method designed to mine gene expression data. The method identifies submatrices of the total expression matrix, whose clustering analysis reveals...
Coupled two-way clustering analysis of breast cancer and colon cancer gene expression data (2003)
Getz, Gad, Gal, Hilah, Kela, Itai, Notterman, Daniel A., Domany, Eytan
We present and review coupled two-way clustering, a method designed to mine gene expression data. The method identifies submatrices of the total expression matrix, whose clustering analysis reveals...
Coupled two-way clustering server (2003)
Summary: The CTWC server provides access to the software, CTWC1.00, that implements Coupled Two Way Clustering (Getz et al., 2000), a method designed to mine gene expression data Availability: Free,...
Coupled Two-Way Clustering Analysis of Breast Cancer and Colon Cancer Gene Expression Data (2002)
Getz, Gad, Gal, Hilah, Kela, Itai, Domany, Eytan, Notterman, Dan A.
We present and review Coupled Two Way Clustering, a method designed to mine gene expression data. The method identifies submatrices of the total expression matrix, whose clustering analysis reveals...
Automated Assignment of SCOP and CATH Protein Structure Classifications from FSSP Scores (2002)
Gad Getz, Michele Vendruscolo, David Sachs, Eytan Domany
We present an automated procedure to assign CATH and SCOP classifications to proteins whose FSSP score is available. CATH classification is assigned down to the topology level and SCOP classification...
Automated assignment of SCOP and CATH protein structure classification from FSSP scores (2001)
Getz, Gad, Vendruscolo, Michele, Sachs, David, Domany, Eytan
We present an automated procedure to assign CATH and SCOP classifications to proteins whose FSSP score is available. CATH classification is assigned down to the topology level and SCOP classification...
Coupled two-way clustering analysis of gene microarray data
Getz, Gad, Levine, Erel, Domany, Eytan
We present a coupled two-way clustering approach to gene microarray data analysis. The main idea is to identify subsets of the genes and samples, such that when one of these is used to cluster the...
Coupled two-way clustering analysis of gene microarray data
Getz, Gad, Levine, Erel, Domany, Eytan
We present a coupled two-way clustering approach to gene microarray data analysis. The main idea is to identify subsets of the genes and samples, such that when one of these is used to cluster the...
Lee, Jeffrey C, Vivanco, Igor, Beroukhim, Rameen, Huang, Julie H. Y, Feng, Whei L, DeBiasi, Ralph M, ...
Ingo Mellinghoff and colleagues sequenced theEGFR gene in glioblastoma samples and cell lines and identified missense mutations in the extracellular domain that suggest a new mechanism for EGFR...
Beroukhim, Rameen, Getz, Gad, Nghiemphu, Leia, Barretina, Jordi, Hsueh, Teli, Linhart, David, ...
Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to analyze cancer genomes...
Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions
Sos, Martin L., Michel, Kathrin, Zander, Thomas, Weiss, Jonathan, Frommolt, Peter, Peifer, Martin, ...
Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. However, no tools...