The ‘‘Alternative’ ’ Choice of Constitutive Exons throughout Evolution (2008)
Galit Lev-maor, Amir Goren, Noa Sela, Eddo Kim, Hadas Keren, Adi Doron-faigenboim, ...
Alternative cassette exons are known to originate from two processes—exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced...
1Department of Human Molecular Genetics and Biochemistry (2008)
Amir Goren, Oren Ram, Maayan Amit, Hadas Keren, Galit Lev-maor, Ida Vig, ...
Exonic splicing regulatory sequences (ESRs) are cisacting factor binding sites that regulate constitutive and alternative splicing. A computational method based on the conservation level of wobble...
Sela, Noa, Mersch, Britta, Gal-Mark, Nurit, Lev-Maor, Galit, Ast, Gil
Background: Transposed elements (TEs) have a substantial impact on mammalian evolution and are involved in numerous genetic diseases. We compared the impact of TEs on the human transcriptome and the...
The Alternative Choice of Constitutive Exons throughout Evolution (2008)
Lev-Maor, Galit, Goren, Amir, Sela, Noa, Kim, Eddo, Keren, Hadas, Doron-Faigenboim, Adi, ...
Alternative cassette exons are known to originate from two processes exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced...
Intronic Alus Influence Alternative Splicing (2008)
Lev-Maor, Galit, Ram, Oren, Kim, Eddo, Sela, Noa, Goren, Amir, Levanon, Erez Y, ...
Examination of the human transcriptome reveals higher levels of RNA editing than in any other organism tested to date. This is indicative of extensive double-stranded RNA (dsRNA) formation within the...
Alternative approach to a heavy weight problem (2008)
Goren, Amir, Kim, Eddo, Amit, Maayan, Bochner, Ron, Lev-Maor, Galit, Ahituv, Nadav, ...
Obesity is reaching epidemic proportions in developed countries and represents a significant risk factor for hypertension, heart disease, diabetes, and dyslipidemia. Splicing mutations constitute at...
The “Alternative” Choice of Constitutive Exons throughout Evolution (2007)
Galit Lev-Maor, Amir Goren, Noa Sela, Eddo Kim, Hadas Keren, Adi Doron-Faigenboim, ...
Alternative cassette exons are known to originate from two processes—exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced...
Sela, Noa, Mersch, Britta, Gal-Mark, Nurit, Lev-Maor, Galit, Hotz-Wagenblatt, Agnes, Ast, Gil
Abstract Background Transposed elements (TEs) have a substantial impact on mammalian evolution and are involved in numerous genetic diseases. We compared the impact of TEs on the human transcriptome...
The Emergence of Alternative 3′ and 5′ Splice Site Exons from Constitutive Exons (2007)
Eli Koren, Galit Lev-Maor, Gil Ast
Alternative 3′ and 5′ splice site (ss) events constitute a significant part of all alternative splicing events. These events were also found to be related to several aberrant splicing diseases....
RNA-editing-mediated exon evolution (2007)
Lev-Maor, Galit, Sorek, Rotem, Levanon, Erez Y, Paz, Nurit, Eisenberg, Eli, Ast, Gil
Abstract Background Alu retroelements are specific to primates and abundant in the human genome. Through mutations that create functional splice sites within intronic Alu s, these elements can become...
Kol, Guy, Lev-Maor, Galit, Ast, Gil
The formation of base-pairing between the branch-site (BS) sequence and the U2 snRNP is an important step in mRNA splicing. We developed a new algorithm to identify both the BS sequence and the...
Kol, Guy, Lev-Maor, Galit, Ast, Gil
The formation of base-pairing between the branch-site sequence and U2 snRNP is an important step in mRNA splicing. We developed a new algorithm to identify both the branch-site sequence and the...
RNA-editing-mediated exon evolution
Lev-Maor, Galit, Sorek, Rotem, Levanon, Erez Y, Paz, Nurit, Eisenberg, Eli, Ast, Gil
A primate-specific exon is found to be dependent on RNA editing for its exonization.
The Emergence of Alternative 3′ and 5′ Splice Site Exons from Constitutive Exons
Koren, Eli, Lev-Maor, Galit, Ast, Gil
Alternative 3′ and 5′ splice site (ss) events constitute a significant part of all alternative splicing events. These events were also found to be related to several aberrant splicing diseases....
The “Alternative” Choice of Constitutive Exons throughout Evolution
Lev-Maor, Galit, Goren, Amir, Sela, Noa, Kim, Eddo, Keren, Hadas, Doron-Faigenboim, Adi, ...
Alternative cassette exons are known to originate from two processes—exonization of intronic sequences and exon shuffling. Herein, we suggest an additional mechanism by which constitutively spliced...
Sela, Noa, Mersch, Britta, Gal-Mark, Nurit, Lev-Maor, Galit, Hotz-Wagenblatt, Agnes, Ast, Gil
Analysis of transposed elements in the human and mouse genomes reveals many effects on the transcriptomes, including a higher level of exonization of Alu elements than other elements.
Alternative approach to a heavy weight problem
Goren, Amir, Kim, Eddo, Amit, Maayan, Bochner, Ron, Lev-Maor, Galit, Ahituv, Nadav, ...
Obesity is reaching epidemic proportions in developed countries and represents a significant risk factor for hypertension, heart disease, diabetes, and dyslipidemia. Splicing mutations constitute at...
Intronic Alus Influence Alternative Splicing
Lev-Maor, Galit, Ram, Oren, Kim, Eddo, Sela, Noa, Goren, Amir, Levanon, Erez Y., ...
Examination of the human transcriptome reveals higher levels of RNA editing than in any other organism tested to date. This is indicative of extensive double-stranded RNA (dsRNA) formation within the...