Ge, Gaoxiang, Hopkins, Delana R., Ho, Wen-Bin, Greenspan, Daniel S.
All transforming growth factor β (TGF-β) superfamily members are synthesized as precursors with prodomain sequences that are proteolytically removed by subtilisin-like proprotein convertases...
Ge, Gaoxiang, Hopkins, Delana R., Ho, Wen-Bin, Greenspan, Daniel S.
All transforming growth factor β (TGF-β) superfamily members are synthesized as precursors with prodomain sequences that are proteolytically removed by subtilisin-like proprotein convertases...
TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2
Wang, Wei-Man, Ge, Gaoxiang, Lim, N. H., Nagase, Hideaki, Greenspan, Daniel S.
ADAMTS-2 is an extracellular metalloproteinase responsible for cleaving the N-propeptides of procollagens I–III; an activity necessary for the formation of collagenous ECM (extracellular matrix)....
BMP1 controls TGFβ1 activation via cleavage of latent TGFβ-binding protein
Ge, Gaoxiang, Greenspan, Daniel S.
Transforming growth factor β1 (TGFβ1), an important regulator of cell behavior, is secreted as a large latent complex (LLC) in which it is bound to its cleaved prodomain (latency-associated peptide...
Bone morphogenetic protein 1 processes prolactin to a 17-kDa antiangiogenic factor
Ge, Gaoxiang, Fernández, Cecilia A., Moses, Marsha A., Greenspan, Daniel S.
In addition to classical expression patterns in pituitary and placenta and functions in growth and reproduction, members of the small family of hormones that includes prolactin (PRL), growth hormone...