Gerlach, Lars-Ole, Hatse, Sigrid, Skerlj, Renato T, Bridger, Gary J, ...
AMD3465 is a novel, nonpeptide CXCR4 antagonist and a potent inhibitor of HIV cell entry in that one of the four-nitrogen cyclam rings of the symmetrical, prototype bicyclam antagonist AMD3100 has...
Princen, Katrien, Bridger, Gary J, ...
The chemokine receptor CXCR3 can exhibit weak coreceptor function for several HIV-1 and HIV-2 strains and clinical isolates. These viruses produced microscopically visible cytopathicity in...
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor (2005)
Rosenkilde, Mette M, Schwartz, Thue W, Hernandez-Abad, Pedro E, ...
The chemokine receptors CCR5 and CXCR4 function as coreceptors for human immunodeficiency virus (HIV) and are attractive targets for the development of anti-HIV drugs. The most potent CXCR4...
Collier, Ann C, Lederman, Michael M, Pollard, Richard B, Brown, Stephen, ...
AMD3100 is a CXCR4 receptor inhibitor with anti-HIV-1 activity in vitro. We tested the safety, pharmacokinetics, and antiviral effect of AMD3100 administered for 10 days by continuous intravenous...
Bridger, Gary J, Skerlj, Renato T, ...
The chemokine receptor CXCR4 is the main coreceptor used by T-tropic X4 HIV-1 strains to infect its target T cells. It has been proven that the CXCR4 expression level in T cells is strongly...
AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity (2002)
Berlin, Aaron, Skerlj, Renato T, Bridger, Gary J
The role of specific chemokine receptors during allergic asthmatic responses has been relatively undefined. A number of receptors are preferentially expressed on Th2 cells, including CCR4, CCR8, and...
Egberink, Herman F., De Clercq, Erik, Balzarini, Jan, Bridger, Gary J., Henson, Geoffrey, ...
Bicyclams are low-molecular-weight anti-human immunodeficiency virus (HIV) agents that have been shown to act as potent and selective CXC chemokine receptor 4 (CXCR4) antagonists. Here, we...
Egberink, Herman F., De Clercq, Erik, Balzarini, Jan, Bridger, Gary J., Henson, Geoffrey, ...
Bicyclams are low-molecular-weight anti-human immunodeficiency virus (HIV) agents that have been shown to act as potent and selective CXC chemokine receptor 4 (CXCR4) antagonists. Here, we...
Hu, Jerry S., Freeman, Christine M., Stolberg, Valerie R., Chiu, Bo Chin, Bridger, Gary J., Fricker, Simon P., ...
CXCR4 is a major receptor for CXCL12 and is known to participate in multiple physiological systems. The present study tested a second generation CXCR4 antagonist, AMD3465, for effects on highly...
AMD3100, a CxCR4 Antagonist, Attenuates Allergic Lung Inflammation and Airway Hyperreactivity
Lukacs, Nicholas W., Berlin, Aaron, Schols, Dominique, Skerlj, Renato T., Bridger, Gary J.
The role of specific chemokine receptors during allergic asthmatic responses has been relatively undefined. A number of receptors are preferentially expressed on Th2 cells, including CCR4, CCR8, and...
Hatse, Sigrid, Huskens, Dana, Princen, Katrien, Vermeire, Kurt, Bridger, Gary J., De Clercq, Erik, ...
The chemokine receptor CXCR3 can exhibit weak coreceptor function for several human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains and clinical isolates. These viruses produced...