Transcription is required for establishment of germline methylation marks at imprinted genes (2009)
Chotalia, Mita, Smallwood, Sebastien A., Ruf, Nico, Dawson, Claire, Lucifero, Diana, Frontera, Marga, ...
Genomic imprinting requires the differential marking by DNA methylation of genes in male and female gametes. In the female germline, acquisition of methylation imprint marks depends upon the de novo...
Ruf, Nico, Bähring, Sylvia, Galetzka, Danuta, Pliushch, Galyna, Luft, Friedrich C., Nürnberg, Peter, ...
Genomic imprinting is the epigenetic marking of gene subsets resulting in monoallelic or predominant expression of one of the two parental alleles according to their parental origin. We describe the...
Stochastic imprinting in the progeny of Dnmt3L-/- females (2006)
Arnaud, Philippe, Hata, Kenichiro, Kaneda, Masahiro, Li, En, Sasaki, Hiroyuki, Feil, Robert, ...
The cis-acting regulatory sequences of imprinted genes are subject to germline-specific epigenetic modifications, the imprints, so that this class of genes is exclusively expressed from either the...
Stochastic imprinting in the progeny of Dnmt3L-/- females (2006)
Arnaud, Philippe, Hata, Kenichiro, Kaneda, Masahiro, Li, En, Sasaki, Hiroyuki, Feil, Robert, ...
The cis-acting regulatory sequences of imprinted genes are subject to germline-specific epigenetic modifications, the imprints, so that this class of genes is exclusively expressed from either the...
Identification of Novel Imprinted Genes in a Genome-Wide Screen for Maternal Methylation (2003)
Smith, Rachel J., Dean, Wendy, Konfortova, Galia, Kelsey, Gavin
A characteristic of imprinted genes is that the maternal and paternal alleles show differences in methylation. To perform a genome-wide screen for novel imprinted loci, we applied...
Arnaud, Philippe, Monk, David, Hitchins, Megan, Gordon, Emma, Dean, Wendy, Beechey, Colin V., ...
Grb10/GRB10 encodes a cytoplasmic adapter protein which modulates coupling of a number of cell surface receptor tyrosine kinases with specific signalling pathways. Mouse Grb10 is an imprinted...
Placental-specific IGF-II is a major modulator of placental and fetal growth (2002)
Constância,Miguel, Hemberger,Myriam, Hughes,Jennifer, Dean,Wendy, Ferguson-Smith,Anne, Fundele,Reinald, ...
Imprinted genes in mammals are expressed from only one of the parental chromosomes, and are crucial for placental development and fetal growth. The insulin-like growth factor II gene (Igf2) is...
Placental-specific IGF-II is a major modulator of placental and fetal growth (2002)
Constância, Miguel, Hemberger, Myriam, Hughes, Jennifer, Dean, Wendy, Ferguson-Smith, Anne, Fundele, Reinald, ...
Imprinted genes in mammals are expressed from only one of the parental chromosomes, and are crucial for placental development and fetal growth. The insulin-like growth factor II gene (Igf2) is...
Takada, Shuji, Paulsen, Martina, Tevendale, Maxine, Tsai, Chen-En, Kelsey, Gavin, Cattanach, Bruce M., ...
Dlk1 and Gtl2 are reciprocally imprinted genes located 80 kb apart on mouse chromosome 12. Similarities between this domain and that of the well characterized Igf2–H19 locus have been previously...
A method for the generation of YAC transgenic mice by pronuclear microinjection (1993)
Sched, Andreas, Larin, Zonia, Montoliu, Lluéis, Thies, Edda Thies, Kelsey, Gavin, Lehrach, Hans, ...
Yeast artificial chromosomes (YACs) represent the latest generation of vectors which have the great advantage of large insert size. The introduction of YACs into mammalian cells and organisms has...
Transgenic mice generated by pronuclear injection of a yeast artificial chromosome (1992)
Schedl, Andreas, Beermann, Friedrich, Thies, Edda, Montoliu, Lluís, Kelsey, Gavin, Schütz, Günther
Transgenic mice have become invaluable for analysing gene function and regulation in vivo. However, the size of constructs injected has been limited by the cloning capacity of conventional vectors, a...
Wroe, Stephanie F., Kelsey, Gavin, Skinner, Judith A., Bodle, Dorothy, Ball, Simon T., Beechey, Colin V., ...
The Gnas locus in distal mouse chromosome (Chr) 2 is emerging as a complex genomic region. It contains three imprinted genes in the order Nesp-Gnasxl-Gnas. Gnas encodes a G protein α-subunit, and...
Peters, Jo, Wroe, Stephanie F., Wells, Christine A., Miller, Howard J., Bodle, Dorothy, Beechey, Colin V., ...
Imprinted genes tend to occur in clusters. We have identified a cluster in distal mouse chromosome (Chr) 2, known from early genetic studies to contain both maternally and paternally imprinted, but...
Coombes, Candice, Arnaud, Philippe, Gordon, Emma, Dean, Wendy, Coar, Elizabeth A., Williamson, Christine M., ...
The Gnas locus in the mouse is imprinted with a complex arrangement of alternative transcripts defined by promoters with different patterns of monoallelic expression. The Gnas transcript is subject...
Identification of Novel Imprinted Genes in a Genome-Wide Screen for Maternal Methylation
Smith, Rachel J., Dean, Wendy, Konfortova, Galia, Kelsey, Gavin
A characteristic of imprinted genes is that the maternal and paternal alleles show differences in methylation. To perform a genome-wide screen for novel imprinted loci, we applied...
Ma, Dan, Shield, Julian P.H., Dean, Wendy, Leclerc, Isabelle, Knauf, Claude, Burcelin, Rémy, ...
Transient neonatal diabetes mellitus (TNDM) is a rare inherited diabetic syndrome apparent in the first weeks of life and again during early adulthood. The relative contributions of reduced islet β...
Imprinted Nesp55 Influences Behavioral Reactivity to Novel Environments
Plagge, Antonius, Isles, Anthony R., Gordon, Emma, Humby, Trevor, Dean, Wendy, Gritsch, Sabine, ...
Genomic imprinting results in parent-of-origin-dependent monoallelic expression of selected genes. Although their importance in development and physiology is recognized, few imprinted genes have been...
An intragenic methylated region in the imprinted Igf2 gene augments transcription
Murrell, Adele, Heeson, Sarah, Bowden, Lucy, Constância, Miguel, Dean, Wendy, Kelsey, Gavin, ...
DNA methylation is usually associated with transcriptional silencing, but in the imprinted mouse Igf2 gene, the paternally expressed copy is methylated in two discrete differentially methylated...
Constância, Miguel, Angiolini, Emily, Sandovici, Ionel, Smith, Paul, Smith, Rachel, Kelsey, Gavin, ...
The mammalian fetus is unique in its dependence during gestation on the supply of maternal nutrients through the placenta. Maternal supply and fetal demand for nutrients need to be fine tuned for...
Wroe, Stephanie F., Kelsey, Gavin, Skinner, Judith A., Bodle, Dorothy, Ball, Simon T., Beechey, Colin V., ...
The Gnas locus in distal mouse chromosome (Chr) 2 is emerging as a complex genomic region. It contains three imprinted genes in the order Nesp-Gnasxl-Gnas. Gnas encodes a G protein α-subunit, and...
Peters, Jo, Wroe, Stephanie F., Wells, Christine A., Miller, Howard J., Bodle, Dorothy, Beechey, Colin V., ...
Imprinted genes tend to occur in clusters. We have identified a cluster in distal mouse chromosome (Chr) 2, known from early genetic studies to contain both maternally and paternally imprinted, but...
Coombes, Candice, Arnaud, Philippe, Gordon, Emma, Dean, Wendy, Coar, Elizabeth A., Williamson, Christine M., ...
The Gnas locus in the mouse is imprinted with a complex arrangement of alternative transcripts defined by promoters with different patterns of monoallelic expression. The Gnas transcript is subject...
Identification of Novel Imprinted Genes in a Genome-Wide Screen for Maternal Methylation
Smith, Rachel J., Dean, Wendy, Konfortova, Galia, Kelsey, Gavin
A characteristic of imprinted genes is that the maternal and paternal alleles show differences in methylation. To perform a genome-wide screen for novel imprinted loci, we applied...
Ma, Dan, Shield, Julian P.H., Dean, Wendy, Leclerc, Isabelle, Knauf, Claude, Burcelin, Rémy, ...
Transient neonatal diabetes mellitus (TNDM) is a rare inherited diabetic syndrome apparent in the first weeks of life and again during early adulthood. The relative contributions of reduced islet β...
Imprinted Nesp55 Influences Behavioral Reactivity to Novel Environments
Plagge, Antonius, Isles, Anthony R., Gordon, Emma, Humby, Trevor, Dean, Wendy, Gritsch, Sabine, ...
Genomic imprinting results in parent-of-origin-dependent monoallelic expression of selected genes. Although their importance in development and physiology is recognized, few imprinted genes have been...
An intragenic methylated region in the imprinted Igf2 gene augments transcription
Murrell, Adele, Heeson, Sarah, Bowden, Lucy, Constância, Miguel, Dean, Wendy, Kelsey, Gavin, ...
DNA methylation is usually associated with transcriptional silencing, but in the imprinted mouse Igf2 gene, the paternally expressed copy is methylated in two discrete differentially methylated...
Constância, Miguel, Angiolini, Emily, Sandovici, Ionel, Smith, Paul, Smith, Rachel, Kelsey, Gavin, ...
The mammalian fetus is unique in its dependence during gestation on the supply of maternal nutrients through the placenta. Maternal supply and fetal demand for nutrients need to be fine tuned for...
Transcription is required for establishment of germline methylation marks at imprinted genes
Chotalia, Mita, Smallwood, Sebastien A., Ruf, Nico, Dawson, Claire, Lucifero, Diana, Frontera, Marga, ...
Genomic imprinting requires the differential marking by DNA methylation of genes in male and female gametes. In the female germline, acquisition of methylation imprint marks depends upon the de novo...