Lundie, Rachel J., Davey, Gayle M., Nie, Catherine Q., Hansen, Diana S., Lau, Lei Shong, ...
Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infection, there is mounting evidence that they are principal mediators of murine experimental cerebral...
Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity
Hänninen, Arno, Martinez, Nathan R., Davey, Gayle M., Heath, William R., Harrison, Leonard C.
Antigen administration via oral and other mucosal routes can suppress systemic immunity to the antigen and has been used to prevent experimental autoimmune disease. This approach may prove...
Transient blockade of CD40 ligand dissociates pathogenic from protective mucosal immunity
Hänninen, Arno, Martinez, Nathan R., Davey, Gayle M., Heath, William R., Harrison, Leonard C.
Antigen administration via oral and other mucosal routes can suppress systemic immunity to the antigen and has been used to prevent experimental autoimmune disease. This approach may prove...
Loss of Bim Increases T Cell Production and Function in Interleukin 7 Receptor–deficient Mice
Pellegrini, Marc, Bouillet, Philippe, Robati, Mikara, Belz, Gabrielle T., Davey, Gayle M., Strasser, Andreas
Interleukin (IL)-7 receptor (R) signaling is essential for T and B lymphopoiesis by promoting proliferation, differentiation, and survival of cells. Mice lacking either IL-7 or the IL-7Rα chain have...
Davey, Gayle M., Starr, Robyn, Cornish, Ann L., Burghardt, J. Theodore, Alexander, Warren S., Carbone, Francis R., ...
Mice that are deficient in suppressor of cytokine signaling–1 (SOCS-1) succumb to neonatal mortality that is associated with extensive cellular infiltration of many tissues. T cells seem to be...
Davey, Gayle M., Kurts, Christian, Bouillet, Philippe, Strasser, Andreas, Brooks, Andrew G., ...
By transgenic expression of ovalbumin (OVA) as a model self antigen in the β cells of the pancreas, we have shown that self tolerance can be maintained by the cross-presentation of this antigen on...
Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells
Davey, Gayle M., Schober, Sonya L., Endrizzi, Bart T., Dutcher, Angela K., Jameson, Stephen C., Hogquist, Kristin A.
During T cell development, thymocytes which are tolerant to self-peptides but reactive to foreign peptides are selected. The current model for thymocyte selection proposes that self-peptide–major...
Caminschi, Irina, Ahmet, Fatma, Heger, Klaus, Brady, Jason, Nutt, Stephen L., Vremec, David, ...
Interferon-producing killer dendritic cells (IKDCs) have been described as possessing the lytic potential of NK cells and the antigen-presenting capacity of dendritic cells (DCs). In this study, we...
The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement
Caminschi, Irina, Proietto, Anna I., Ahmet, Fatma, Kitsoulis, Susie, Shin Teh, Joo, Lo, Jennifer C. Y., ...
A novel dendritic cell (DC)–restricted molecule, Clec9A, was identified by gene expression profiling of mouse DC subtypes. Based on sequence similarity, a human ortholog was identified. Clec9A...
Lundie, Rachel J., Davey, Gayle M., Nie, Catherine Q., Hansen, Diana S., Lau, Lei Shong, ...
Although CD8+ T cells do not contribute to protection against the blood stage of Plasmodium infection, there is mounting evidence that they are principal mediators of murine experimental cerebral...
The molecular signature of CD8+ T cells undergoing deletional tolerance
Parish, Ian A., Rao, Sudha, Smyth, Gordon K., Juelich, Torsten, Denyer, Gareth S., Davey, Gayle M., ...
Peripheral tolerance induction is critical for the maintenance of self-tolerance and can be mediated by immunoregulatory T cells or by direct induction of T-cell anergy or deletion. Although the...
Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance
Parish, Ian A., Waithman, Jason, Davey, Gayle M., Belz, Gabrielle T., Mintern, Justine D., Kurts, Christian, ...
Autoimmune diseases tend to be chronic and progressive, but how these responses are sustained is not clear. One cell type that might contribute to autoimmunity is the cytotoxic T lymphocyte (CTL),...
Transience of MHC Class I-restricted antigen presentation after influenza A virus infection
Mintern, Justine D., Bedoui, Sammy, Davey, Gayle M., Moffat, Jessica M., Doherty, Peter C., Turner, Stephen J.
Antigen expressed as MHC Class I glycoprotein (pMHCI) complexes on dendritic cells is the primary driver of CD8+ T cell clonal expansion and differentiation. As we seek to define the molecular...