Gen Suzuki

Primary central nervous system lymphoma in Japan: Changes in clinical features, treatment, and prognosis during 1985-2004 (2008)

Shibamoto, Yuta, Ogino, Hiroyuki, Suzuki, Gen, Takemoto, Mitsuhiro, Araki, Norio, Isobe, Koichi, ...

We have conducted nationwide surveys of primary central nervous system lymphoma (PCNSL) treated since 1985. In the present study, we newly collected data between 2000 and 2004 and investigated...

Effects of Radiation on the Longitudinal Trends of Hemoglobin Levels in the Japanese Atomic Bomb Survivors (2005)

F. Lennie Wong, Michiko Yamada, Tan Tominaga, Saeko Fujiwara, Gen Suzuki

Wong, F. L., Yamada, M., Tominaga, T., Fujiwara, S. and Suzuki, G. Effects of Radiation on the Longitudinal Trends of Hemoglobin Levels in the Japanese Atomic Bomb Survivors. Radiat. Res. 164,...

Noncancer Disease Incidence in Atomic Bomb Survivors, 1958–1998 (2004)

Michiko Yamada, F. Lennie Wong, Saeko Fujiwara, Masazumi Akahoshi, Gen Suzuki

Yamada, M., Wong, F. L., Fujiwara, S., Akahoshi, M. and Suzuki, G. Noncancer Disease Incidence in the Atomic Bomb Survivors, 1958–1998. Radiat. Res. 161, 622–632 (2004). We examined the...

An Association between Oxidative Stress and Radiation-Induced Lymphomagenesis (2004)

Gen Suzuki, Yoshiya Shimada, Tomonori Hayashi, Makoto Akashi, Toshiyasu Hirama, Yoichiro Kusunoki

Suzuki, G., Shimada, Y., Hayashi, T., Akashi, M., Hirama, T. and Kusunoki, Y. An Association between Oxidative Stress and Radiation-Induced Lymphomagenesis. Radiat. Res. 161, 642–647 (2004). It is...

Prevalence of Hepatitis B Virus Infection among Atomic Bomb Survivors (2003)

Saeko Fujiwara, Gerald B. Sharp, John B. Cologne, Shizuyo Kusumi, Masazumi Akahoshi, Kazunori Kodama, ...

Fujiwara, S., Sharp, G. B., Cologne, J. B., Kusumi, S., Akahoshi, M., Kodama, K., Suzuki, G. and Yoshizawa, H. Prevalence of Hepatitis B Virus Infection among Atomic Bomb Survivors. Radiat. Res. 159,...

Spectrum of Znfn1a1 (Ikaros) Inactivation and its Association with Loss of Heterozygosity in Radiogenic T-Cell Lymphomas in Susceptible B6C3F1 Mice (2002)

Shizuko Kakinuma, Mayumi Nishimura, Syun-Ichi Sasanuma, Kazuei Mita, Gen Suzuki, Yoshimoto Katsura, ...

Kakinuma, S., Nishimura, M., Sasanuma, S-I., Mita, K., Suzuki, G., Katsura, Y., Sado, T. and Shimada, Y. Spectrum of Znfn1a1 (Ikaros) Inactivation and its Association with Loss of Heterozygosity in...

Variability of contractile reserve in hibernating myocardium: dependence on the method of inotropic stimulation (2002)

Malm, Brian J, Suzuki, Gen, Canty, John M, Fallavollita, James A

Objective: Contractile reserve during graded β-adrenergic stimulation identifies viability in patients with left ventricular dysfunction. Nevertheless, contractile reserve is frequently absent in...

Influence of Thoracic Radiotherapy on Exhaled Nitric Oxide Levels in Patients with Lung Cancer (2001)

Koizumi, Masahiko, Yamazaki, Hideya, Toyokawa, Kazushige, Yoshioka, Yasuo, Suzuki, Gen, Ito, Masami, ...

Background: To determine the physiological role of exhaled nitric oxide (NO) in patients with lung cancer. Methods: We investigated changes in exhaled NO levels in 29 patients undergoing thoracic...

Control of CD4 T cell fate by antigen re-stimulation with or without CTLA-4 engagement 24 h after priming (2000)

Nakata, Yukiko, Uzawa, Akiko, Suzuki, Gen

After two consecutive inoculations with Staphylococcus enterotoxin B (SEB) at 24 h intervals in vivo, CD4 T cells became anergic to the antigen challenge in vitro. Administration of anti-CTLA-4 mAb...

An alternate pathway for type 1 T cell differentiation (1999)

Feng, Chiguang, Watanabe, Shohei, Maruyama, Saho, Suzuki, Gen, Sato, Mitsuharu, Furuta, Takahisa, ...

IFN-regulatory factor-1 (IRF-1) gene-disrupted mice are defective in IL-12 and IL-18 gene expression at the transcriptional and post-translational level respectively. The mutant mouse mounts a type 2...

Increased c-Fos/activator protein-1 confers resistance against anergy induction on antigen-specific T cell (1999)

Nakata, Yukiko, Suzuki, Gen, Chihara, Kazuo, Tokuhisa, Takeshi, Shiozawa, Shunichi

We have studied the contribution of c-Fos/activator protein-1 (AP-1) to antigen-specific T cell response with reference to T cell anergy by increasing c-Fos/AP-1 in vivo and in vitro. First, after...

Impaired CD28-mediated co-stimulation in anergic T cells (1995)

Suzuki, Gen, Nomura, Masayuki, Uzawa, Akiko, Akashi, Makoto, Nakata, Yukiko, Taniguchi, M.

We have investigated a CD28 co-stimulation in anergic T cells in staphylococcal enterotoxin Binoculated mice by stimulating the cells with a plate-coated anti-TCR antibody in the presence or absence...

Characterization of p59fyn-mediated signal transduction on T cell activation (1994)

Fusaki, Noemi, Semba, Kentaro, Katagiri, Takuya, Suzuki, Gen, Matsuda, Satoru, Yamamoto, Tadashi

Protein tyrosine kinase p59fyn is associated with the TCR - CD3 complex and is suggested to play a role in T cell activation. To determine the molecular mechanism of p59fyn-medlated signal...

The role of macrophages in antigen presentation and T cell tolerance (1993)

Miyazaki, Toru, Suzuki, Gen, Yamamura, Ken-ichi, Taniguchi, M.

Bone marrow derived cells (dendritic cells, macrophages and B cells) are involved in antigen presentation and T cell tolerance. However, the precise functions of each cell type remain unclear. To...

T cell clones are killed by a thymic stromal cell monolayer following stamulation of T cell receptor with antigen and/or H-2 molecules on the monolayer (1990)

Matsubara, Hidetoshi, Kosaka, Hiroshi, Sogo, Shinji, Maruo, Seiji, Sugihara, Shigetaka, Asano, Yoshihiro, ...

A thymic stromal cell clone, MRL104.8a, expressed class I and class II H-2k antigens after exposure to γ-interferon (γ-IFN) and produced thymic stroma-derived T cell growth factor (TSTGF)...

RNA transcripts for I-J polypeptides are apparently not encoded between the I-A and I-E subregions of the murine major histocompatibility complex (1983)

Kronenberg, Mitchell, Steinmetz, Michael, Kobori, Joan, Kraig, Ellen, Kapp, Judith A., Pierce, Carl W., ...

The I-J subregion of the mouse major histocompatibility complex has been reported to encode antigenic determinants expressed by suppressor T cells. Previously, cosmid clones were obtained from mouse...

Feasibility of Freeze-Dried Sera for Serological and Molecular Biological Detection of Hepatitis B and C Viruses▿

Ohishi, Waka, Fujiwara, Saeko, Suzuki, Gen, Kishi, Takeshi, Sora, Misae, Matsuura, Shinsuke, ...

We compared hepatitis B virus (HBV) surface antigen, anti-hepatitis C virus (HCV) antibody, and HCV RNA quantification in frozen and freeze-dried serum samples to assess the usefulness of...

A Coordinated Change in Chemokine Responsiveness Guides Plasma Cell Movements

Hargreaves, Diana C., Hyman, Paul L., Lu, Theresa T., Ngo, Vu N., Bidgol, Afshin, Suzuki, Gen, ...

Antibody-secreting plasma cells are nonrecirculatory and lodge in splenic red pulp, lymph node medullary cords, and bone marrow. The factors that regulate plasma cell localization are poorly defined....

Disturbed CD4+ T Cell Homeostasis and In Vitro HIV-1 Susceptibility in Transgenic Mice Expressing T Cell Line–tropic HIV-1 Receptors

Sawada, Shinichiro, Gowrishankar, Kavitha, Kitamura, Rui, Suzuki, Misao, Suzuki, Gen, Tahara, Satoko, ...

T cell line–tropic (T-tropic) HIV type 1 strains enter cells by interacting with the cell-surface molecules CD4 and CXCR4. We have generated transgenic mice predominantly expressing human CD4 and...

Primary central nervous system lymphoma in Japan: Changes in clinical features, treatment, and prognosis during 1985–2004

Shibamoto, Yuta, Ogino, Hiroyuki, Suzuki, Gen, Takemoto, Mitsuhiro, Araki, Norio, Isobe, Koichi, ...

We have conducted nationwide surveys of primary central nervous system lymphoma (PCNSL) treated since 1985. In the present study, we newly collected data between 2000 and 2004 and investigated...

Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice

Sidhu, Sukhdeep, Gangasani, Ashish, Korotchkina, Lioubov G., Suzuki, Gen, Fallavollita, James A., Canty, John M., ...

Pyruvate dehydrogenase complex (PDC) plays an important role in energy homeostasis in the heart by catalyzing the oxidative decarboxylation of pyruvate derived primarily from glucose and lactate....