Gen Wang

Myxoma Virus M11L Prevents Apoptosis through Constitutive Interaction with Bak

Wang, Gen, Barrett, John W., Nazarian, Steven H., Everett, Helen, Gao, Xiujuan, Bleackley, Chris, ...

M11L, a 166-amino-acid antiapoptotic protein of myxoma virus, was previously shown to bind to the peripheral benzodiazepine receptor by hydrophobic interactions at the outer mitochondrial membrane....

Myxoma Virus M11L Blocks Apoptosis through Inhibition of Conformational Activation of Bax at the Mitochondria

Su, Jin, Wang, Gen, Barrett, John W., Irvine, Timothy S., Gao, Xiujuan, McFadden, Grant

Many viruses inhibit or retard apoptosis, a strategy that subverts one of the most ancient antiviral mechanisms. M11L, a myxoma virus-encoded antiapoptotic protein, has been previously shown to...

Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor

Wang, Gen, Barrett, John W., Stanford, Marianne, Werden, Steven J., Johnston, James B., Gao, Xiujuan, ...

We demonstrate that the susceptibility of human cancer cells to be infected and killed by an oncolytic poxvirus, myxoma virus (MV), is related to the basal level of endogenous phosphorylated Akt. We...

Myxoma Virus M11L Prevents Apoptosis through Constitutive Interaction with Bak

Wang, Gen, Barrett, John W., Nazarian, Steven H., Everett, Helen, Gao, Xiujuan, Bleackley, Chris, ...

M11L, a 166-amino-acid antiapoptotic protein of myxoma virus, was previously shown to bind to the peripheral benzodiazepine receptor by hydrophobic interactions at the outer mitochondrial membrane....

Myxoma Virus M11L Blocks Apoptosis through Inhibition of Conformational Activation of Bax at the Mitochondria

Su, Jin, Wang, Gen, Barrett, John W., Irvine, Timothy S., Gao, Xiujuan, McFadden, Grant

Many viruses inhibit or retard apoptosis, a strategy that subverts one of the most ancient antiviral mechanisms. M11L, a myxoma virus-encoded antiapoptotic protein, has been previously shown to...

Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor

Wang, Gen, Barrett, John W., Stanford, Marianne, Werden, Steven J., Johnston, James B., Gao, Xiujuan, ...

We demonstrate that the susceptibility of human cancer cells to be infected and killed by an oncolytic poxvirus, myxoma virus (MV), is related to the basal level of endogenous phosphorylated Akt. We...

AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells

Sun, Mei, Wang, Gen, Paciga, June E., Feldman, Richard I., Yuan, Zeng-Qiang, Ma, Xiao-Ling, ...

Extensive studies have demonstrated that the Akt/AKT1 pathway is essential for cell survival and inhibition of apoptosis; however, alterations of Akt/AKT1 in human primary tumors have not been well...

M-T5, the Ankyrin Repeat, Host Range Protein of Myxoma Virus, Activates Akt and Can Be Functionally Replaced by Cellular PIKE-A▿

Werden, Steven J., Barrett, John W., Wang, Gen, Stanford, Marianne M., McFadden, Grant

The myxoma virus (MV) ankyrin repeat, host range factor M-T5 has the ability to bind and activate cellular Akt, leading to permissive MV replication in a variety of diverse human cancer cell lines...