Gen Wen

An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension (2007)

Wen, Gen, Wessel, Jennifer, Zhou, Weidong, Ehret, Georg B., Rao, Fangwen, Stridsberg, Mats, ...

Granins regulate secretory vesicle formation in neuroendocrine cells and granin-derived peptides are co-released with neurotransmitters as modulatory signals at sympathetic sites. We report evidence...

Mutation Rate and Predicted Phenotypic Target Sizes in Ethylnitrosourea-Treated Mice

Concepcion, Dorothy, Seburn, Kevin L., Wen, Gen, Frankel, Wayne N., Hamilton, Bruce A.

Chemical mutagenesis of the mouse is ongoing in several centers around the world, with varying estimates of mutation rate and number of sites mutable to phenotype. To address these questions, we...

Both Rare and Common Polymorphisms Contribute Functional Variation at CHGA, a Regulator of Catecholamine Physiology

Wen, Gen, Mahata, Sushil K., Cadman, Peter, Mahata, Manjula, Ghosh, Sajalendu, Mahapatra, Nitish R., ...

The chromogranin/secretogranin proteins are costored and coreleased with catecholamines from secretory vesicles in chromaffin cells and noradrenergic neurons. Chromogranin A (CHGA) regulates...

Mutation Rate and Predicted Phenotypic Target Sizes in Ethylnitrosourea-Treated Mice

Concepcion, Dorothy, Seburn, Kevin L., Wen, Gen, Frankel, Wayne N., Hamilton, Bruce A.

Chemical mutagenesis of the mouse is ongoing in several centers around the world, with varying estimates of mutation rate and number of sites mutable to phenotype. To address these questions, we...

Chromogranin A Polymorphisms Are Associated With Hypertensive Renal Disease

Salem, Rany M., Cadman, Peter E., Chen, Yuqing, Rao, Fangwen, Wen, Gen, Hamilton, Bruce A., ...

Chromogranin A is released together with epinephrine and norepinephrine from catecholaminergic cells. Specific endopeptidases cleave chromogranin A into biologically active peptide fragments,...