Gener Balmes

FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway (2009)

Matsushita, Takehiko, Wilcox, William R., Chan, Yuk Yu, Kawanami, Aya, Bükülmez, Hülya, Balmes, Gener, ...

Activating mutations in FGFR3 cause achondroplasia and thanatophoric dysplasia, the most common human skeletal dysplasias. In these disorders, spinal canal and foramen magnum stenosis can cause...

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype (2004)

Murakami, Shunichi, Balmes, Gener, McKinney, Sandra, Zhang, Zhaoping, Givol, David, De Crombrugghe, Benoit

We generated transgenic mice that express a constitutively active mutant of MEK1 in chondrocytes. These mice showed a dwarf phenotype similar to achondroplasia, the most common human dwarfism, caused...

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype

Murakami, Shunichi, Balmes, Gener, McKinney, Sandra, Zhang, Zhaoping, Givol, David, De Crombrugghe, Benoit

We generated transgenic mice that express a constitutively active mutant of MEK1 in chondrocytes. These mice showed a dwarf phenotype similar to achondroplasia, the most common human dwarfism, caused...

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

Akiyama‡, Haruhiko, Kim‡, Jung-Eun, Nakashima, Kazuhisa, Balmes, Gener, Iwai, Naomi, Deng, Jian Min, ...

The transcription factor Sox9 is expressed in all chondroprogenitors and has an essential role in chondrogenesis. Sox9 is also expressed in other tissues, including central nervous system, neural...

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype

Murakami, Shunichi, Balmes, Gener, McKinney, Sandra, Zhang, Zhaoping, Givol, David, De Crombrugghe, Benoit

We generated transgenic mice that express a constitutively active mutant of MEK1 in chondrocytes. These mice showed a dwarf phenotype similar to achondroplasia, the most common human dwarfism, caused...

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

Akiyama‡, Haruhiko, Kim‡, Jung-Eun, Nakashima, Kazuhisa, Balmes, Gener, Iwai, Naomi, Deng, Jian Min, ...

The transcription factor Sox9 is expressed in all chondroprogenitors and has an essential role in chondrogenesis. Sox9 is also expressed in other tissues, including central nervous system, neural...