Timothy B. Hallett, Simon Gregson, Sabada Dube, Geoff P. Garnett
BackgroundThe roll-out of antiretroviral treatment (ART) in developing countries concentrates on finding patients currently in need, but over time many HIV-infected individuals will be identified who...
Lopman, Ben, Nyamukapa, Constance, Mushati, Phyllis, Mupambireyi, Zivai, Mason, Peter, Garnett, Geoff P, ...
Background In recent years, HIV prevalence has begun to decline in Zimbabwe, which has been associated with reductions in sexual risk behaviour. Here, we analyse the determinants of HIV incidence in...
Who is getting Pap smears in urban Peru? (2008)
Paz Soldan, Valerie A, Lee, Frank H, Carcamo, Cesar, Holmes, King K, Garnett, Geoff P, Garcia, Patricia
Background Cervical cancer, although usually preventable by Pap smear screening, remains the leading cause of cancer-related deaths among women in Peru. The percentages and characteristics of women...
Geoff P. Garnett, Kamal Desai, John Williams
The influence of a vaccine with a range of different properties has been explored in a mathematical model of the spread of HIV in a heterosexual population, reflecting the generalized epidemics...
Geoff P. Garnett, Kamal Desai, John Williams
The influence of a vaccine with a range of different properties has been explored in a mathematical model of the spread of HIV in a heterosexual population, reflecting the generalized epidemics...
Desai, Kamal, Boily, Marie-Claude, Garnett, Geoff P, Mâsse, Benoît R, Moses, Stephen, Bailey, Robert C
Abstract Background A landmark randomised trial of male circumcision (MC) in Orange Farm, South Africa recently showed a large and significant reduction in risk of HIV infection, reporting MC...
Ben A. Lopman, Ruanne V. Barnabas, J. Ties Boerma, Godwin Chawira, Kezia Gaitskell, Tara Harrop, ...
BackgroundVital registration and cause of death reporting is incomplete in the countries in which the HIV epidemic is most severe. A reliable tool that is independent of HIV status is needed for...
Ruanne V. Barnabas, Päivi Laukkanen, Pentti Koskela, Osmo Kontula, Matti Lehtinen, Geoff P. Garnett
Using a mathematical model of transmission of HPV 16 infection and progression to cervical cancer, Ruanne Barnabas and colleagues show that HPV vaccination could significantly decrease HPV...
Ruanne V. Barnabas, Päivi Laukkanen, Pentti Koskela, Osmo Kontula, Matti Lehtinen, Geoff P. Garnett
BackgroundCandidate human papillomavirus (HPV) vaccines have demonstrated almost 90%-100% efficacy in preventing persistent, type-specific HPV infection over 18 mo in clinical trials. If these...
Modelling the Impact of Antiretroviral Use in Resource-Poor Settings (2006)
Rebecca F. Baggaley, Geoff P. Garnett, Neil M. Ferguson
Modelling results suggest that antiretrovirals will not work as direct prevention tools, and that concurrent promotion of safe sex practices is essential to prevent increased transmission.
Modelling the Impact of Antiretroviral Use in Resource-Poor Settings (2006)
Rebecca F. Baggaley, Geoff P. Garnett, Neil M. Ferguson
Background The anticipated scale-up of antiretroviral therapy (ART) in high-prevalence, resource-constrained settings requires operational research to guide policy on the design of treatment...
The epidemiological impact of antiretroviral use predicted by mathematical models: a review (2005)
Baggaley, Rebecca F, Ferguson, Neil M, Garnett, Geoff P
Abstract This review summarises theoretical studies attempting to assess the population impact of antiretroviral therapy (ART) use on mortality and HIV incidence. We describe the key parameters that...
Authors' Reply: Don't Let the Hypothesis Slip (2005)
Ben A. Lopman, Geoff P. Garnett, Simon Gregson, Simon Gregson, Peter R. Mason
Authors' Reply: Don't Let the Hypothesis Slip (2005)
Ben A. Lopman, Geoff P. Garnett, Simon Gregson, Simon Gregson, Peter R. Mason
Ben A. Lopman, Geoff P. Garnett, Peter R. Mason, Simon Gregson
A debate is raging over whether unsafe medical injections are an important cause of HIV infection in Africa; in rural Zimbabwe evidence suggests they are not.
Ben A. Lopman, Geoff P. Garnett, Peter R. Mason, Simon Gregson
Background It has recently been argued that unsafe medical injections are a major transmission route of HIV infection in the generalised epidemics of sub-Saharan Africa. Methods and Findings We have...
Rebecca F Baggaley, Neil M Ferguson, Geoff P Garnett, Rebecca F Baggaley, Neil M Ferguson, Geoff P Garnett
This review summarises theoretical studies attempting to assess the population impact of antiretroviral therapy (ART) use on mortality and HIV incidence. We describe the key parameters that determine...
Antiviral therapy and the transmission dynamics of HIV-1 (1996)
Garnett, Geoff P., Anderson, Roy M.
The factors influencing the transmission dynamics of HIV are discussed in the context of the community wide use of antiviral therapy. A mathematical framework is constructed to examine the impact of...
Ferguson, Neil M., DeWolf, Frank, Ghani, Azra C., Fraser, Christophe, Donnelly, Christl A., Reiss, Peter, ...
Antigen-induced stimulation of the immune system can generate heterogeneity in CD4+ T cell division rates capable of explaining the temporal patterns seen in the decay of HIV-1 plasma RNA levels...
Individual Level Injection History: A Lack of Association with HIV Incidence in Rural Zimbabwe
Lopman, Ben A, Garnett, Geoff P, Mason, Peter R, Gregson, Simon
A debate is raging over whether unsafe medical injections are an important cause of HIV infection in Africa; in rural Zimbabwe evidence suggests they are not
Back to basics in HIV prevention: focus on exposure
Pisani, Elizabeth, Garnett, Geoff P, Grassly, Nicholas C, Brown, Tim, Stover, John, Hankins, Catherine, ...
Despite worldwide efforts to prevent HIV infection, the number of people affected continues to rise. The authors of this article argue that a commonsense approach based on simple country by country...
Authors' Reply: Don't Let the Hypothesis Slip
Lopman, Ben A, Garnett, Geoff P, Gregson, Simon, Gregson, Simon, Mason, Peter R
The epidemiological impact of antiretroviral use predicted by mathematical models: a review
Baggaley, Rebecca F, Ferguson, Neil M, Garnett, Geoff P
This review summarises theoretical studies attempting to assess the population impact of antiretroviral therapy (ART) use on mortality and HIV incidence. We describe the key parameters that determine...
Modelling the Impact of Antiretroviral Use in Resource-Poor Settings
Baggaley, Rebecca F, Garnett, Geoff P, Ferguson, Neil M
Modelling results suggest that antiretrovirals will not work as direct prevention tools, and that concurrent promotion of safe sex practices is essential to prevent increased transmission.
Barnabas, Ruanne V, Laukkanen, Päivi, Koskela, Pentti, Kontula, Osmo, Lehtinen, Matti, Garnett, Geoff P
Using a mathematical model of transmission of HPV 16 infection and progression to cervical cancer, Ruanne Barnabas and colleagues show that HPV vaccination could significantly decrease HPV...
Lopman, Ben A, Barnabas, Ruanne V, Boerma, J. Ties, Chawira, Godwin, Gaitskell, Kezia, Harrop, Tara, ...
Based on verbal autopsy from patients in rural Zimbabwe, 69% of deaths were correctly classified as AIDS/non-AIDS. The authors say the method can be used in demographic surveillance on AIDS deaths.
Ferguson, Neil M., DeWolf, Frank, Ghani, Azra C., Fraser, Christophe, Donnelly, Christl A., Reiss, Peter, ...
Antigen-induced stimulation of the immune system can generate heterogeneity in CD4+ T cell division rates capable of explaining the temporal patterns seen in the decay of HIV-1 plasma RNA levels...
Individual Level Injection History: A Lack of Association with HIV Incidence in Rural Zimbabwe
Lopman, Ben A, Garnett, Geoff P, Mason, Peter R, Gregson, Simon
A debate is raging over whether unsafe medical injections are an important cause of HIV infection in Africa; in rural Zimbabwe evidence suggests they are not
Back to basics in HIV prevention: focus on exposure
Pisani, Elizabeth, Garnett, Geoff P, Grassly, Nicholas C, Brown, Tim, Stover, John, Hankins, Catherine, ...
Despite worldwide efforts to prevent HIV infection, the number of people affected continues to rise. The authors of this article argue that a commonsense approach based on simple country by country...
Authors' Reply: Don't Let the Hypothesis Slip
Lopman, Ben A, Garnett, Geoff P, Gregson, Simon, Gregson, Simon, Mason, Peter R
The epidemiological impact of antiretroviral use predicted by mathematical models: a review
Baggaley, Rebecca F, Ferguson, Neil M, Garnett, Geoff P
This review summarises theoretical studies attempting to assess the population impact of antiretroviral therapy (ART) use on mortality and HIV incidence. We describe the key parameters that determine...
Modelling the Impact of Antiretroviral Use in Resource-Poor Settings
Baggaley, Rebecca F, Garnett, Geoff P, Ferguson, Neil M
Modelling results suggest that antiretrovirals will not work as direct prevention tools, and that concurrent promotion of safe sex practices is essential to prevent increased transmission.
Barnabas, Ruanne V, Laukkanen, Päivi, Koskela, Pentti, Kontula, Osmo, Lehtinen, Matti, Garnett, Geoff P
Using a mathematical model of transmission of HPV 16 infection and progression to cervical cancer, Ruanne Barnabas and colleagues show that HPV vaccination could significantly decrease HPV...
Lopman, Ben A, Barnabas, Ruanne V, Boerma, J. Ties, Chawira, Godwin, Gaitskell, Kezia, Harrop, Tara, ...
Based on verbal autopsy from patients in rural Zimbabwe, 69% of deaths were correctly classified as AIDS/non-AIDS. The authors say the method can be used in demographic surveillance on AIDS deaths.
Desai, Kamal, Boily, Marie-Claude, Garnett, Geoff P, Mâsse, Benoît R, Moses, Stephen, Bailey, Robert C
Hallett, Timothy B, Gregson, Simon, Dube, Sabada, Garnett, Geoff P
Using a stochastic model based on data from Africa, Timothy Hallett and colleagues find that starting HIV treatment based on regular CD4 monitoring, rather than on symptoms, would substantially...
The epidemiological impact of an HIV/AIDS vaccine in developing countries
Stover, John, Garnett, Geoff P., Seitz, Steve, Forsythe, Steven
Many people see an effective preventive AIDS vaccine as the best solution to the HIV/AIDS pandemic. Ten years ago many scientists had hoped that a vaccine would be available by now. Most scientists...
Understanding the Impact of Male Circumcision Interventions on the Spread of HIV in Southern Africa
Hallett, Timothy B., Singh, Kanwarjit, Smith, Jennifer A., White, Richard G., Abu-Raddad, Laith J., Garnett, Geoff P.
Bernabé-Ortiz, Antonio, White, Peter J., Carcamo, Cesar P., Hughes, James P., Gonzales, Marco A., Garcia, Patricia J., ...
AIDS: the makings of a development disaster?
Geoff P Garnett, Nicholas C Grassly, Simon Gregson
No abstract
Errors in ‘BED’-Derived Estimates of HIV Incidence Will Vary by Place, Time and Age
Hallett, Timothy B., Ghys, Peter, Bärnighausen, Till, Yan, Ping, Garnett, Geoff P.
Assessing adult mortality in HIV-1-afflicted Zimbabwe (1998 -2003).
Lopman, Ben A., Barnabas, Ruanne, Hallett, Timothy B., Nyamukapa, Constance, Mundandi, Costa, Mushati, Phyllis, ...
OBJECTIVE: To compare alternative methods to vital registration systems for estimating adult mortality, and describe patterns of mortality in Manicaland, Zimbabwe, which has been severely affected by...
Monitoring the scale-up of antiretroviral therapy programmes: methods to estimate coverage.
Boerma, J. Ties, Stanecki, Karen A., Newell, Marie-Louise, Luo, Chewe, Beusenberg, Michel, Garnett, Geoff P., ...
This paper reviews the data sources and methods used to estimate the number of people on, and coverage of, antiretroviral therapy (ART) programmes in low- and middle-income countries and to monitor...
Who is getting Pap smears in urban Peru?
Paz Soldan, Valerie A, Lee, Frank H, Carcamo, Cesar, Holmes, King K, Garnett, Geoff P, Garcia, Patricia
Background Cervical cancer, although usually preventable by Pap smear screening, remains the leading cause of cancer-related deaths among women in Peru. The percentages and characteristics of women...