Geoffrey A. Donnan

Good laboratory practice: preventing introduction of bias at the bench (2009)

Macleod, Malcolm R., Fisher, Marc, O'Collins, Victoria, Sena, Emily S., Dirnagl, Ulrich, Bath, Philip M.W., ...

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human...

PUT THEIR LIVES BACK IN THEIR HANDS (2009)

Geoffrey A Donnan

Pretend you’re warm and leave cardigan undone Get someone to do it up for you – again Just do cardigan up yourself

Telmisartan to prevent recurrent stroke and cardiovascular events (2008)

Yusuf, S, Diener, HC, Sacco, RL, Cotton, D, Ounpuu, S, Lawton, WA, ...

Background Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients reduces the rate...

Telmisartan to prevent recurrent stroke and cardiovascular events (2008)

Yusuf, Salim, Diener, Hans-Christoph, Sacco, Ralph L., Cotton, Daniel, Ounpuu, Stephanie, Lawton, William A., ...

Background Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients reduces the rate...

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke (2008)

Sacco, Ralph L., Diener, Hans-Christoph, Yusuf, Salim, Cotton, Daniel, Ounpuu, Stephanie, Lawton, William A., ...

Background Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens — aspirin plus extendedrelease...

The Virtual International Stroke Trials Archive (2007)

Myzoon, Ali, Bath, Philip M.W., Curram, John, Davis, Stephen M, Diener, Hans-Christoph, Donnan, Geoffrey A, ...

Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of...

The Virtual International Stroke Trials Archive (2007)

Myzoon, Ali, Bath, Philip M.W., Curram, John, Davis, Stephen M., Diener, Hans-Christoph, Donnan, Geoffrey A., ...

Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of...

The Virtual International Stroke Trials Archive (2007)

Ali, Myzoon, Bath, Philip M.W., Curram, John, Davis, Stephen M., Diener, Hans-Christoph, Donnan, Geoffrey A., ...

BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of...

Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis (2007)

Van Der Worp, H. Bart, Sena, Emily S., Donnan, Geoffrey A., Howells, David W., Macleod, Malcolm R.

Induced hypothermia is proposed as a treatment for acute ischaemic stroke, but there have been too few clinical trials involving too few patients to draw any conclusions about the therapeutic benefit...

Improving access to evidence-based acute stroke services: development and evaluation of a health systems model to address equity of access issues (2006)

Cadilhac, Dominique A, Moodie, Marjory, Lalor, Erin E., Donnan, Geoffrey A.

Level 1 evidence for management of patients with stroke in a dedicated Stroke Care Unit (SCU) demonstrates improved outcomes by about 20%. It has been estimated that 21% of Australian hospitals...

Improving access to evidence-based acute stroke services: development and evaluation of a health systems model to address equity of access issues (2006)

Cadilhac, Dominique A, Moodie, Marjory, Lalor, Erin E., Donnan, Geoffrey A.

Level 1 evidence for management of patients with stroke in a dedicated Stroke Care Unit (SCU) demonstrates improved outcomes by about 20%. It has been estimated that 21% of Australian hospitals...

Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable (2005)

Fisher, Marc, Albers, Gregory W., Donnan, Geoffrey A., Furlan, Anthony J., Grotta, James, Kidwell, Chelsea S., ...

BACKGROUND: Previous Stroke Therapy Academic Industry Roundtable (STAIR) meetings focused on preclinical evidence of drug efficacy and enhancing acute stroke trial design and performance. A fourth...

Smoking as a Crucial Independent Determinant of Stroke (2004)

Paul, Seana L, Thrift, Amanda G, Donnan, Geoffrey A

Abstract Background Although smoking is known to be powerful risk factor for other vascular diseases, such as cardiac and peripheral vascular disease, only relatively recently has evidence for the...

Trial application of a model of resource utiliztion, costs, and outcomes for stroke (MORUCOS) to assist priority setting in stroke. (2004)

Moodie, Marjory, Carter, Rob, Mihalopoulos, Cathy, Thrift, Amanda G., Chambers, Brian R., Donnan, Geoffrey A., ...

Background and Purpose— Cost-effectiveness data for stroke interventions are limited, and comparisons between studies are confounded by methodological inconsistencies. The aim of this study was...

Trial application of a model of resource utiliztion, costs, and outcomes for stroke (MORUCOS) to assist priority setting in stroke. (2004)

Moodie, Marjory, Carter, Rob, Mihalopoulos, Cathy, Thrift, Amanda G., Chambers, Brian R., Donnan, Geoffrey A., ...

Background and Purpose— Cost-effectiveness data for stroke interventions are limited, and comparisons between studies are confounded by methodological inconsistencies. The aim of this study was...

The functional magnetic resonance imaging hemodynamic response to faces remains stable until the ninth decade (2003)

Brodtmann, Amy, Darby, David, Donnan, Geoffrey A., Puce, Aina, Syngeniotis, Ari

The effects of aging on blood oxygen level dependent signal changes and the hemodynamic response (HDR) remain controversial. Using functional magnetic resonance (MR) imaging, we examined the HDR...

The functional magnetic resonance imaging hemodynamic response to faces remains stable until the ninth decade (2003)

Brodtmann, Amy, Darby, David, Donnan, Geoffrey A., Puce, Aina, Syngeniotis, Ari

The effects of aging on blood oxygen level dependent signal changes and the hemodynamic response (HDR) remain controversial. Using functional magnetic resonance (MR) imaging, we examined the HDR...

The functional magnetic resonance imaging hemodynamic response to faces remains stable until the ninth decade (2003)

Brodtmann, Amy, Darby, David, Donnan, Geoffrey A., Puce, Aina, Syngeniotis, Ari

The effects of aging on blood oxygen level dependent signal changes and the hemodynamic response (HDR) remain controversial. Using functional magnetic resonance (MR) imaging, we examined the HDR...

The functional magnetic resonance imaging hemodynamic response to faces remains stable until the ninth decade (2003)

Brodtmann, Amy, Darby, David, Donnan, Geoffrey A., Puce, Aina, Syngeniotis, Ari

The effects of aging on blood oxygen level dependent signal changes and the hemodynamic response (HDR) remain controversial. Using functional magnetic resonance (MR) imaging, we examined the HDR...

`Out of pocket` costs to stroke patients during the first year after stroke - results from the North East Melbourne stroke incidence study (2003)

Dewey, Helen M., Thrift, Amanda G., Mihalopoulos, Cathy, Carter, Rob, Macdonell, Richard A. L., McNeil, John J., ...

Non-reimbursed ‘out of pocket’ costs to stroke patients have not been included in existing cost of illness studies. We aimed to determine the nature and magnitude of ‘out of...

Lifetime cost of stroke subtypes in Australia: findings from the North East Melbourne stroke incidence study (NEMESIS) (2003)

Dewey, Helen M., Thrift, Amanda G., Mihalopoulos, Cathy, Carter, Rob, Macdonell, Richard A. L., McNeil, John J., ...

Background and Purpose-: Little is known about any variations in resource use and costs of care between stroke subtypes, especially nonhospital costs. The purpose of this study was to describe the...

The functional magnetic resonance imaging hemodynamic response to faces remains stable until the ninth decade (2003)

Brodtmann, Amy, Darby, David, Donnan, Geoffrey A., Puce, Aina, Syngeniotis, Ari

The effects of aging on blood oxygen level dependent signal changes and the hemodynamic response (HDR) remain controversial. Using functional magnetic resonance (MR) imaging, we examined the HDR...

`Out of pocket` costs to stroke patients during the first year after stroke - results from the North East Melbourne stroke incidence study (2003)

Dewey, Helen M., Thrift, Amanda G., Mihalopoulos, Cathy, Carter, Rob, Macdonell, Richard A. L., McNeil, John J., ...

Non-reimbursed ‘out of pocket’ costs to stroke patients have not been included in existing cost of illness studies. We aimed to determine the nature and magnitude of ‘out of...

Lifetime cost of stroke subtypes in Australia: findings from the North East Melbourne stroke incidence study (NEMESIS) (2003)

Dewey, Helen M., Thrift, Amanda G., Mihalopoulos, Cathy, Carter, Rob, Macdonell, Richard A. L., McNeil, John J., ...

Background and Purpose-: Little is known about any variations in resource use and costs of care between stroke subtypes, especially nonhospital costs. The purpose of this study was to describe the...

Reemergence of activation with poststroke somatosensory recovery: a serial fMRI case study (2002)

Abbott, David F., Carey, Leanne M., Donnan, Geoffrey A., Jackson, Graeme D., Puce, Aina, Syngeniotis, Ari, ...

The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory...

Reemergence of activation with poststroke somatosensory recovery: a serial fMRI case study (2002)

Abbott, David F., Carey, Leanne M., Donnan, Geoffrey A., Jackson, Graeme D., Puce, Aina, Syngeniotis, Ari

The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory...

Reemergence of activation with poststroke somatosensory recovery: a serial fMRI case study (2002)

Abbott, David F., Carey, Leanne M., Donnan, Geoffrey A., Jackson, Graeme D., Puce, Aina, Syngeniotis, Ari

The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory...

Reemergence of activation with poststroke somatosensory recovery: a serial fMRI case study (2002)

Abbott, David F., Carey, Leanne M., Donnan, Geoffrey A., Jackson, Graeme D., Puce, Aina, Syngeniotis, Ari

The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory...

Reemergence of activation with poststroke somatosensory recovery: a serial fMRI case study (2002)

Abbott, David F., Carey, Leanne M., Donnan, Geoffrey A., Jackson, Graeme D., Puce, Aina, Syngeniotis, Ari

The authors demonstrate the potential for poststroke return of activation in regions normally involved in touch discrimination in a serial, whole-brain fMRI study of a patient with marked sensory...

Cost of stroke in Australia from a societal perspective: results from the north east Melbourne stroke incidence study (NEMESIS) (2001)

Dewey, Helen M., Thrift, Amanda G., Mihalopoulos, Cathy, Carter, Rob, Macdonell, Richard A. L., McNeil, John J., ...

Background and Purpose—— Accurate information about resource use and costs of stroke is necessary for informed health service planning. The purpose of this study was to determine the...

Cost of stroke in Australia from a societal perspective: results from the north east Melbourne stroke incidence study (NEMESIS) (2001)

Dewey, Helen M., Thrift, Amanda G., Mihalopoulos, Cathy, Carter, Rob, Macdonell, Richard A. L., McNeil, John J., ...

Background and Purpose—— Accurate information about resource use and costs of stroke is necessary for informed health service planning. The purpose of this study was to determine the...

Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke

Sacco, RL, Diener, Hans-Christoph, Yusuf, S, Cotton, D, Ounpuu, S, Lawton, WA, ...

Background Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens — aspirin plus extendedrelease...