Kawamoto, Kensaku, Lobach, David F, Willard, Huntington F, Ginsburg, Geoffrey S
Abstract Background In recent years, the completion of the Human Genome Project and other rapid advances in genomics have led to increasing anticipation of an era of genomic and personalized...
Gene Expression Signatures That Predict Radiation Exposure in Mice and Humans (2007)
Holly K. Dressman, Garrett G. Muramoto, Nelson J. Chao, Sarah Meadows, Dawn Marshall, Geoffrey S. Ginsburg, ...
BackgroundThe capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen...
Embracing the complexity of genomic data for personalized medicine (2006)
West, Mike, Ginsburg, Geoffrey S., Huang, Andrew T., Nevins, Joseph R.
Numerous recent studies have demonstrated the use of genomic data, particularly gene expression signatures, as clinical prognostic factors in cancer and other complex diseases. Such studies herald...
Gene Expression Signatures That Predict Radiation Exposure in Mice and Humans
Dressman, Holly K, Muramoto, Garrett G, Chao, Nelson J, Meadows, Sarah, Marshall, Dawn, Ginsburg, Geoffrey S, ...
John Chute and colleagues report that gene expression patterns in peripheral blood mononuclear cells from mice and humans reflect prior radiation exposure.
Genomic medicine: genetic variation and its impact on the future of health care
Willard, Huntington F, Angrist, Misha, Ginsburg, Geoffrey S
Advances in genome technology and other fruits of the Human Genome Project are playing a growing role in the delivery of health care. With the development of new technologies and opportunities for...
Peripheral blood gene expression profiling for cardiovascular disease assessment
Aziz, Hamza, Zaas, Aimee, Ginsburg, Geoffrey S.
Whole blood gene expression profiling has the potential to be informative about dynamic changes in disease states and to provide information on underlying disease mechanisms. Having demonstrated...
Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis
Shah, Svati H., Freedman, Neil J., Zhang, Lisheng, Crosslin, David R., Stone, David H., Haynes, Carol, ...
Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up...
Meadows, Sarah K., Dressman, Holly K., Muramoto, Garrett G., Himburg, Heather, Salter, Alice, Wei, ZhengZheng, ...
High heritability of metabolomic profiles in families burdened with premature cardiovascular disease
Shah, Svati H, Hauser, Elizabeth R, Bain, James R, Muehlbauer, Michael J, Haynes, Carol, Stevens, Robert D, ...
Integration of genetic and metabolic profiling holds promise for providing insight into human disease. Coronary artery disease (CAD) is strongly heritable, but the heritability of metabolomic...
Garman, Katherine S., Acharya, Chaitanya R., Edelman, Elena, Grade, Marian, Gaedcke, Jochen, Sud, Shivani, ...
Gene expression profiles provide an opportunity to dissect the heterogeneity of solid tumors, including colon cancer, to improve prognosis and predict response to therapies. Bayesian binary...
Gene Expression Patterns in Peripheral Blood Correlate with the Extent of Coronary Artery Disease
Sinnaeve, Peter R., Donahue, Mark P., Grass, Peter, Seo, David, Vonderscher, Jacky, Chibout, Salah-Dine, ...
Systemic and local inflammation plays a prominent role in the pathogenesis of atherosclerotic coronary artery disease, but the relationship of whole blood gene expression changes with coronary...