Georg M. N. Behrens

Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and anti-viral immunity (2006)

Wilson, Nicholas S., Behrens, Georg M. N., Lundie, Rachel J., Smith, Christopher M., Waithman, Jason, Young, Louise, ...

The mechanisms responsible for the immunosuppression associated with sepsis or some chronic blood infections remain poorly understood. Here we show that infection with a malaria parasite (Plasmodium...

Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1–infected patients with lipodystrophy

Behrens, Georg M.N., Boerner, Anne-Rose, Weber, Klaus, Van Den Hoff, Joerg, Ockenga, Johann, Brabant, Georg, ...

Insulin resistance is a frequently observed side effect of highly active antiretroviral therapy (HAART). Currently, very little is known about the mechanisms or specific tissues involved. We aimed to...

Impaired glucose phosphorylation and transport in skeletal muscle cause insulin resistance in HIV-1–infected patients with lipodystrophy

Behrens, Georg M.N., Boerner, Anne-Rose, Weber, Klaus, Van Den Hoff, Joerg, Ockenga, Johann, Brabant, Georg, ...

Insulin resistance is a frequently observed side effect of highly active antiretroviral therapy (HAART). Currently, very little is known about the mechanisms or specific tissues involved. We aimed to...

The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture

Schnorrer, Petra, Behrens, Georg M. N., Wilson, Nicholas S., Pooley, Joanne L., Smith, Christopher M., El-Sukkari, Dima, ...

Mouse spleens contain three populations of conventional (CD11chigh) dendritic cells (DCs) that play distinct functions. The CD8+ DC are unique in that they can present exogenous antigens on their MHC...

The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens

Belz, Gabrielle T., Behrens, Georg M.N., Smith, Chris M., Jones, Claerwen, Lejon, Kristina, ...

We previously described a mechanism for the maintenance of peripheral self-tolerance. This involves the cross-presentation of tissue-associated antigens by a bone marrow–derived cell type that...

Zidovudine Impairs Adipogenic Differentiation through Inhibition of Clonal Expansion▿

Stankov, Metodi V., Schmidt, Reinhold E., Behrens, Georg M. N.

Lipoatrophy is a prevalent side effect of treatment with thymidine analogues. We wished to confine the time point of the antiadipogenic effect of zidovudine (AZT) during adipogenesis and to evaluate...