Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis (2009)
Beyer, Christian, Schett, Georg, Gay, Steffen, Distler, Oliver, Distler, Jörg HW
Abstract Autoimmunity, microangiopathy and tissue fibrosis are hallmarks of systemic sclerosis (SSc). Vascular alterations and reduced capillary density decrease blood flow and impair tissue...
Osteoimmunology in rheumatic diseases (2009)
Abstract This review summarizes the recent advances of osteoimmunology, a new research field that investigates the interaction of the immune system with the skeleton. Osteoimmunology has contributed...
Sudden visual loss in a patient with microscopic polyangiitis (2009)
Wacker, Jochen, Handschu, Rene, Manger, Bernhard, Schett, Georg, Zwerina, Jochen
Abstract Inflammation and degradation of bone are two closely linked processes. Chronic inflammatory arthritis not only leads to inflammatory bone loss but it also involves local erosion of articular...
Cells of the synovium in rheumatoid arthritis. Osteoclasts (2007)
Abstract Osteoclasts are multinucleated cells of hematopoietic origin and are the primary bone resorbing cells. Numerous osteoclasts are found within the synovial tissue at sites adjacent to bone,...
Zwerina, Jochen, Tuerk, Birgit, Redlich, Kurt, Smolen, Josef S, Schett, Georg
Abstract Chronic arthritis typically leads to loss of periarticular bone, which results from an imbalance between bone formation and bone resorption. Recent research has focused on the role of...
Görtz, Birgit, Hayer, Silvia, Tuerck, Birgit, Zwerina, Jochen, Smolen, Josef S, Schett, Georg
Abstract Tumour necrosis factor (TNF) is considered to be a major factor in chronic synovial inflammation and is an inducer of mitogen-activated protein kinase (MAPK) signalling. In the present study...
JNK1 is not essential for TNF-mediated joint disease (2004)
Köller, Marcus, Hayer, Silvia, Redlich, Kurt, Ricci, Romeo, David, Jean-Pierre, Steiner, Günter, ...
Abstract Tumour necrosis factor (TNF) signalling molecules are considered as promising therapeutic targets of antirheumatic therapy. Among them, mitogen-activated protein kinases are thought to be of...
The role of osteoprotegerin in arthritis (2003)
Schett, Georg, Redlich, Kurt, Smolen, Josef S
Abstract Bone erosion is a hallmark of rheumatoid arthritis. Recent evidence from experimental arthritis suggests that osteoclasts are essential for the formation of local bone erosions. Two...
El negocio de la electricidad (2002)
El sector eléctrico ha cambiado profundamente durante los últimos años: el proceso de desregulación, privatización y liberalización, e incluso de nueva reglamen-tación, está transformando el...
El negocio de la electricidad (2002)
El sector eléctrico ha cambiado profundamente durante los últimos años: el proceso de desregulación, privatización y liberalización, e incluso de nueva reglamen-tación, está transformando el...
Schett, Georg, Tohidast-Akrad, Makiyeh, Steiner, Günter, Smolen, Josef
Abstract This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory...
Schett, Georg, Metzler, Bernhard, Amberger, Albert, Recheis, Heidrun, Xu, Qingbo, ...
Objective: While atherosclerosis is associated with high titers of autoantibodies to bacterial hsp65 crossreacting with human hsp60 (anti-hsp60 autoantibodies), myocardial infarction entails...
Schett, Georg, Tohidast-Akrad, Makiyeh, Steiner, Günter, Smolen, Josef
This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and...
Osteoclasts are essential for TNF-α–mediated joint destruction
Redlich, Kurt, Hayer, Silvia, Ricci, Romeo, David, Jean-Pierre, Tohidast-Akrad, Makiyeh, Kollias, George, ...
The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the question of...
The role of osteoprotegerin in arthritis
Schett, Georg, Redlich, Kurt, Smolen, Josef S
Bone erosion is a hallmark of rheumatoid arthritis. Recent evidence from experimental arthritis suggests that osteoclasts are essential for the formation of local bone erosions. Two essential...
Amberger, Albert, Maczek, Christian, Jürgens, Günther, Michaelis, Dorothea, Schett, Georg, Trieb, Klemens, ...
T-cells and monocytes are the first cells infiltrating the arterial intima during the early stages of atherogenesis. Recently our laboratory has provided evidence that T-cells isolated from...
JNK1 is not essential for TNF-mediated joint disease
Köller, Marcus, Hayer, Silvia, Redlich, Kurt, Ricci, Romeo, David, Jean-Pierre, Steiner, Günter, ...
Tumour necrosis factor (TNF) signalling molecules are considered as promising therapeutic targets of antirheumatic therapy. Among them, mitogen-activated protein kinases are thought to be of central...
Schett, Georg, Herak, Petra, Graninger, Winfried, Smolen, Josef S., Aringer, Martin
Listeriosis can be a cause of infectious arthritis. Here, we present a case of articular listeriosis in a patient with rheumatoid arthritis receiving treatment with etanercept, a tumor necrosis...
Görtz, Birgit, Hayer, Silvia, Tuerck, Birgit, Zwerina, Jochen, Smolen, Josef S, Schett, Georg
Tumour necrosis factor (TNF) is considered to be a major factor in chronic synovial inflammation and is an inducer of mitogen-activated protein kinase (MAPK) signalling. In the present study we...
Zwerina, Jochen, Tuerk, Birgit, Redlich, Kurt, Smolen, Josef S, Schett, Georg
Chronic arthritis typically leads to loss of periarticular bone, which results from an imbalance between bone formation and bone resorption. Recent research has focused on the role of...
Schett, Georg, Tohidast-Akrad, Makiyeh, Steiner, Günter, Smolen, Josef
This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and...
Osteoclasts are essential for TNF-α–mediated joint destruction
Redlich, Kurt, Hayer, Silvia, Ricci, Romeo, David, Jean-Pierre, Tohidast-Akrad, Makiyeh, Kollias, George, ...
The detailed cellular and molecular mechanisms leading to joint destruction in rheumatoid arthritis, a disease driven by proinflammatory cytokines, are still unknown. To address the question of...
The role of osteoprotegerin in arthritis
Schett, Georg, Redlich, Kurt, Smolen, Josef S
Bone erosion is a hallmark of rheumatoid arthritis. Recent evidence from experimental arthritis suggests that osteoclasts are essential for the formation of local bone erosions. Two essential...
Amberger, Albert, Maczek, Christian, Jürgens, Günther, Michaelis, Dorothea, Schett, Georg, Trieb, Klemens, ...
T-cells and monocytes are the first cells infiltrating the arterial intima during the early stages of atherogenesis. Recently our laboratory has provided evidence that T-cells isolated from...
JNK1 is not essential for TNF-mediated joint disease
Köller, Marcus, Hayer, Silvia, Redlich, Kurt, Ricci, Romeo, David, Jean-Pierre, Steiner, Günter, ...
Tumour necrosis factor (TNF) signalling molecules are considered as promising therapeutic targets of antirheumatic therapy. Among them, mitogen-activated protein kinases are thought to be of central...
Schett, Georg, Herak, Petra, Graninger, Winfried, Smolen, Josef S., Aringer, Martin
Listeriosis can be a cause of infectious arthritis. Here, we present a case of articular listeriosis in a patient with rheumatoid arthritis receiving treatment with etanercept, a tumor necrosis...
Görtz, Birgit, Hayer, Silvia, Tuerck, Birgit, Zwerina, Jochen, Smolen, Josef S, Schett, Georg
Tumour necrosis factor (TNF) is considered to be a major factor in chronic synovial inflammation and is an inducer of mitogen-activated protein kinase (MAPK) signalling. In the present study we...
Zwerina, Jochen, Tuerk, Birgit, Redlich, Kurt, Smolen, Josef S, Schett, Georg
Chronic arthritis typically leads to loss of periarticular bone, which results from an imbalance between bone formation and bone resorption. Recent research has focused on the role of...
Redlich, Kurt, Görtz, Birgit, Hayer, Silvia, Zwerina, Jochen, Doerr, Nicholas, Kostenuik, Paul, ...
Local bone erosion and systemic bone loss are hallmarks of rheumatoid arthritis and cause progressive disability. Tumor necrosis factor (TNF) is a key mediator of arthritis and acts catabolically on...
Cells of the synovium in rheumatoid arthritis. Osteoclasts
Osteoclasts are multinucleated cells of hematopoietic origin and are the primary bone resorbing cells. Numerous osteoclasts are found within the synovial tissue at sites adjacent to bone, creating...
Inflammation and degradation of bone are two closely linked processes. Chronic inflammatory arthritis not only leads to inflammatory bone loss but it also involves local erosion of articular bone....
TNF-induced structural joint damage is mediated by IL-1
Zwerina, Jochen, Redlich, Kurt, Polzer, Karin, Joosten, Leo, Krönke, Gerhard, Distler, Joerg, ...
Blocking TNF effectively inhibits inflammation and structural damage in human rheumatoid arthritis (RA). However, so far it is unclear whether the effect of TNF is a direct one or indirect on...
Ruocco, Maria Grazia, Maeda, Shin, Park, Jin Mo, Lawrence, Toby, Hsu, Li-Chung, Cao, Yixue, ...
Transcription factor, nuclear factor κB (NF-κB), is required for osteoclast formation in vivo and mice lacking both of the NF-κB p50 and p52 proteins are osteopetrotic. Here we address the...
CD44 is a determinant of inflammatory bone loss
Hayer, Silvia, Steiner, Günter, Görtz, Birgit, Reiter, Erika, Tohidast-Akrad, Makiyeh, Amling, Michael, ...
Chronic inflammation is a major trigger of local and systemic bone loss. Disintegration of cell–matrix interaction is a prerequisite for the invasion of inflammatory tissue into bone. CD44 is a...
Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis
Beyer, Christian, Schett, Georg, Gay, Steffen, Distler, Oliver, Distler, Jörg HW
Autoimmunity, microangiopathy and tissue fibrosis are hallmarks of systemic sclerosis (SSc). Vascular alterations and reduced capillary density decrease blood flow and impair tissue oxygenation in...
Osteoimmunology in rheumatic diseases
This review summarizes the recent advances of osteoimmunology, a new research field that investigates the interaction of the immune system with the skeleton. Osteoimmunology has contributed...
Urbonaviciute, Vilma, Fürnrohr, Barbara G., Meister, Silke, Munoz, Luis, Heyder, Petra, De Marchis, Francesco, ...
Autoantibodies against double-stranded DNA (dsDNA) and nucleosomes represent a hallmark of systemic lupus erythematosus (SLE). However, the mechanisms involved in breaking the immunological tolerance...
Remodeling of joints is a key feature of inflammatory and degenerative joint disease. Bone erosion, cartilage degeneration and growth of bony spurs termed osteophytes are key features of structural...