George Davey Smith

Cardiorespiratory risk factors as predictors of 40-year mortality in women and men. (2009)

Ferrie, Jane, Singh-Manoux, Archana, Kivimaki, Mika, Mindell, Jennifer, Breeze, Elizabeth, Davey Smith, George, ...

OBJECTIVE: Most historical studies of cardiorespiratory risk factors as predictors of mortality have been based on men. This study examines whether they predict mortality over long periods in women...

Cardiorespiratory risk factors as predictors of 40-year mortality in women and men. (2009)

Ferrie, Jane, Singh-Manoux, Archana, Kivimaki, Mika, Mindell, Jennifer, Breeze, Elizabeth, Davey Smith, George, ...

OBJECTIVE: Most historical studies of cardiorespiratory risk factors as predictors of mortality have been based on men. This study examines whether they predict mortality over long periods in women...

Cardiorespiratory risk factors as predictors of 40-year mortality in women and men. (2009)

Ferrie, Jane, Singh-Manoux, Archana, Kivimaki, Mika, Mindell, Jennifer, Breeze, Elizabeth, Davey Smith, George, ...

OBJECTIVE: Most historical studies of cardiorespiratory risk factors as predictors of mortality have been based on men. This study examines whether they predict mortality over long periods in women...

The Impact of Residual and Unmeasured Confounding in Epidemiologic Studies: A Simulation Study (2007)

Fewell, Zoe, Davey Smith, George, Sterne, Jonathan A. C.

Measurement error in explanatory variables and unmeasured confounders can cause considerable problems in epidemiologic studies. It is well recognized that under certain conditions, nondifferential...

Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE (2007)

Alharbi, Khalid K., Spanakis, Emmanuel, Tan, Karen, Smith, Matt J., Aldahmesh, Mohammed A., O'Dell, Sandra D., ...

Identification of unknown mutations has remained laborious, expensive, and only viable for studies of selected cases. Population-based "reference ranges" of rarer sequence diversity are not...

The association of the paraoxonase (PON1) Q192R polymorphism with depression in older women: findings from the British women's heart and health study (2007)

Lawlor, Debbie A., Day, Ian N.M., Gaunt, Tom R., Hinks, Lesley J., Timpson, Nick, Ebrahim, Shah, ...

Background: The association between the R allele of PON1 Q192R and symptoms reported by sheep dippers and Gulf War veterans has been used to suggest a biological basis for these symptoms. In the...

Measuring socioeconomic position in health research (2007)

Galobardes, Bruna, Lynch, John, Davey Smith, George

Objective In this article we review different measures of socioeconomic position (SEP) and their uses in health-related research. Areas of agreement Socioeconomic circumstances influence health. ...

Measuring socioeconomic position in health research (2007)

Galobardes, Bruna, Lynch, John, Davey Smith, George

Objective In this article we review different measures of socioeconomic position (SEP) and their uses in health-related research. Areas of agreement Socioeconomic circumstances influence health. ...

Nutritional interventions and outcome in patients with cancer or preinvasive lesions: systematic review (2006)

Davey Smith, George, Harbord, Roger, Sterne, Jonathan A C, Beynon, Rebecca, ...

BACKGROUND: Dietary modifications and supplements are used widely by patients with cancer and preinvasive lesions as an adjunct to standard treatment. Given the widespread use of nutritional...

Adult Blood Pressure and Climate Conditions in Infancy: A Test of the Hypothesis that Dehydration in Infancy Is Associated with Higher Adult Blood Pressure (2006)

Lawlor, Debbie A., Davey Smith, George, Mitchell, Richard, Ebrahim, Shah

The authors hypothesized that individuals born in the early 20th century who experienced the hottest and driest summers during infancy would be more likely to have suffered severe infant diarrhea and...

ZIP-Code-based versus Tract-based Income Measures as Long-Term Risk-adjusted Mortality Predictors (2006)

Thomas, Avis J., Eberly, Lynn E., Davey Smith, George, Neaton, James D.

There is a well-established, strong association between socioeconomic position and mortality. Public health mortality analyses thus routinely consider the confounding effect of socioeconomic position...

Nutritional Interventions and Outcome in Patients With Cancer or Preinvasive Lesions: Systematic Review (2006)

Davies, Anna A., Davey Smith, George, Harbord, Roger, Bekkering, Geertruida E., Sterne, Jonathan A. C., Beynon, Rebecca, ...

Background: Dietary modifications and supplements are used widely by patients with cancer and preinvasive lesions as an adjunct to standard treatment. Given the widespread use of nutritional...

The Relation between Components of Adult Height and Intimal-Medial Thickness in Middle Age: The Atherosclerosis Risk in Communities Study (2006)

Tilling, Kate, Lawlor, Debbie A., Davey Smith, George, Chambless, Lloyd, Szklo, Moyses

The authors aimed to investigate the relation between components of adult height (leg and trunk length) and atherosclerosis in middle age, using data from 12,254 participants (aged 44–65 years) in...

Association of Childhood Socioeconomic Position with Cause-specific Mortality in a Prospective Record Linkage Study of 1,839,384 Individuals (2006)

Lawlor, Debbie A., Sterne, Jonathan A. C., Tynelius, Per, Davey Smith, George, Rasmussen, Finn

Previous studies have lacked sufficient power to assess associations between early-life socioeconomic position and adult cause-specific mortality. The authors examined associations of parental social...

Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality (2005)

Davey Smith, George, Lawlor, Debbie A., Harbord, Roger, Timpson, Nic, Rumley, Ann, Lowe, Gordon D.O., ...

Background: C-reactive protein (CRP) has repeatedly been associated with blood pressure and prevalent and incident hypertension, but whether a causal link exists is uncertain. Methods and Results: We...

C-reactive protein and its role in metabolic syndrome: mendelian randomisation study (2005)

Timpson, Nicholas J., Lawlor, Debbie A., Harbord, Roger M., Gaunt, Tom R., Day, Proflan N.M., Palmer, Lyle J., ...

BACKGROUND: Circulating C-reactive protein (CRP) is associated with the metabolic syndrome and might be causally linked to it. Our aim was to generate estimates of the association between plasma CRP...

Breastfeeding in Infancy and Blood Pressure in Later Life: Systematic Review and Meta-Analysis (2005)

Martin, Richard M., Gunnell, David, Davey Smith, George

The influence of breastfeeding on blood pressure in later life is uncertain. The authors conducted a systematic review of published studies from which estimates of a mean difference (standard error)...

Cause-specific hospital admission and mortality among working men: association with socioeconomic circumstances in childhood and adult life, and the mediating role of daily stress (2005)

Metcalfe, Chris, Davey Smith, George, Sterne, Jonathan A. C., Heslop, Pauline, Macleod, John, Hart, Carole L.

Background: The aim of this study was to investigate the association of childhood and adulthood social class with the occurrence of specific diseases, including those not associated with a high...

Advanced Paternal Age and Risk of Fetal Death: A Cohort Study (2004)

Nybo Andersen, Anne-Marie, Hansen, Kasper Daniel, Andersen, Per Kragh, Davey Smith, George

A possible detrimental paternal age effect on offspring health due to mutations of paternal origin should be reflected in an association between paternal age and fetal loss. The authors used data...

(Mis)use of Factor Analysis in the Study of Insulin Resistance Syndrome (2004)

Lawlor, Debbie A., Ebrahim, Shah, May, Margaret, Davey Smith, George

Over the last decade, factor analysis has been used increasingly to describe patterns of simultaneous occurrence of the central components of the insulin resistance syndrome. In this paper, the...

Breastfeeding and cardiovascular mortality: the Boyd Orr cohort and a systematic review with meta-analysis (2004)

Martin, Richard M, Davey Smith, George, Mangtani, Punam, Tilling, Kate, Frankel, Stephen, Gunnell, David

Aims To investigate the association of breastfeeding with all-cause, cardiovascular, and ischaemic heart disease mortality. Methods and results A long-term follow-up of 4999 children originally...

Life and death of the people of London: a historical GIS of Charles Booth's inquiry (2002)

Orford, Scott, Dorling, Danny, Mitchell, Richard, Shaw, Mary, Davey Smith, George

Social reformer Charles Booth undertook a massive survey into the social and economic conditions of the people of London at the end of the 19th century. An important innovation of his Inquiry was the...

Life and death of the people of London: a historical GIS of Charles Booth's inquiry (2002)

Orford, Scott, Dorling, Danny, Mitchell, Richard, Shaw, Mary, Davey Smith, George

Social reformer Charles Booth undertook a massive survey into the social and economic conditions of the people of London at the end of the 19th century. An important innovation of his Inquiry was the...

Is There a Sex Difference in the Association between Birth Weight and Systolic Blood Pressure in Later Life? Findings from a Meta-Regression Analysis (2002)

Lawlor, Debbie A., Ebrahim, Shah, Davey Smith, George

The aim of this study was to determine whether a sex difference exists in the association between birth weight and systolic blood pressure. A meta-analysis of all observational studies (n =...

Lifestyle, health, and health promotion in Nazi Germany

Davey Smith, George

Several health related behaviours came under scrutiny in the 1930s and '40s in Germany, but did the associated campaigns achieve any benefits?

Coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and prevalence of infection in the United Kingdom general population: cross sectional study

Macleod, John, Salisbury, Chris, Low, Nicola, McCarthy, Anne, Sterne, Jonathan A C, Holloway, Aisha, ...

Objective To measure the coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and the prevalence of infection in the general population in the United Kingdom. To...

Health inequalities and New Labour: how the promises compare with real progress

Shaw, Mary, Davey Smith, George, Dorling, Danny

Inequalities in health between rich and poor areas of Britain widened in the 1980s and 1990s, and the current government has repeatedly expressed its intention to reduce these inequalities. In this...

What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?

Davey Smith, George, Ebrahim, Shah

Using genetic variants as a proxy for modifiable environmental factors that are associated with disease can circumvent some of the problems of observational studies

Association of socioeconomic position with insulin resistance among children from Denmark, Estonia, and Portugal: cross sectional study

Lawlor, Debbie A, Harro, Maarike, Wedderkopp, Niels, Andersen, Lars Bo, Sardinha, Luis B, Riddoch, Chris J, ...

Objectives To examine the association between socioeconomic position and insulin resistance in children from three countries in northern Europe (Denmark), eastern Europe (Estonia), and southern...

Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?

Lewis, Sarah J, Ebrahim, Shah, Davey Smith, George

Objectives To investigate the association between the MTHFR 677C→T polymorphism and coronary heart disease, assessing small study bias and heterogeneity between studies.

Is Social Capital the Key to Inequalities in Health?

Pearce, Neil, Davey Smith, George

There has been vigorous debate between the “social capital” and “neomaterialist” interpretations of the epidemiological evidence regarding socioeconomic determinants of health. We argue that...

Leisure Time Physical Activity and Disease-Specific Mortality Among Men With Chronic Bronchitis: Evidence From the Whitehall Study

Batty, G. David, Shipley, Martin J., Marmot, Michael G., Davey Smith, George

Objectives. This study examined the association between leisure time physical activity and cause-specific mortality among male Whitehall Study participants with chronic bronchitis.

Socioeconomic Position and Hormone Replacement Therapy Use: Explaining the Discrepancy in Evidence From Observational and Randomized Controlled Trials

Lawlor, Debbie A, Davey Smith, George, Ebrahim, Shah

Objectives. We assessed the association between life-course socioeconomic status or position (SEP) and hormone replacement therapy (HRT).

Lifestyle, health, and health promotion in Nazi Germany

Davey Smith, George

Several health related behaviours came under scrutiny in the 1930s and '40s in Germany, but did the associated campaigns achieve any benefits?

Coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and prevalence of infection in the United Kingdom general population: cross sectional study

Macleod, John, Salisbury, Chris, Low, Nicola, McCarthy, Anne, Sterne, Jonathan A C, Holloway, Aisha, ...

Objective To measure the coverage and uptake of systematic postal screening for genital Chlamydia trachomatis and the prevalence of infection in the general population in the United Kingdom. To...

Health inequalities and New Labour: how the promises compare with real progress

Shaw, Mary, Davey Smith, George, Dorling, Danny

Inequalities in health between rich and poor areas of Britain widened in the 1980s and 1990s, and the current government has repeatedly expressed its intention to reduce these inequalities. In this...

What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?

Davey Smith, George, Ebrahim, Shah

Using genetic variants as a proxy for modifiable environmental factors that are associated with disease can circumvent some of the problems of observational studies

Association of socioeconomic position with insulin resistance among children from Denmark, Estonia, and Portugal: cross sectional study

Lawlor, Debbie A, Harro, Maarike, Wedderkopp, Niels, Andersen, Lars Bo, Sardinha, Luis B, Riddoch, Chris J, ...

Objectives To examine the association between socioeconomic position and insulin resistance in children from three countries in northern Europe (Denmark), eastern Europe (Estonia), and southern...

Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?

Lewis, Sarah J, Ebrahim, Shah, Davey Smith, George

Objectives To investigate the association between the MTHFR 677C→T polymorphism and coronary heart disease, assessing small study bias and heterogeneity between studies.

Is Social Capital the Key to Inequalities in Health?

Pearce, Neil, Davey Smith, George

There has been vigorous debate between the “social capital” and “neomaterialist” interpretations of the epidemiological evidence regarding socioeconomic determinants of health. We argue that...

Leisure Time Physical Activity and Disease-Specific Mortality Among Men With Chronic Bronchitis: Evidence From the Whitehall Study

Batty, G. David, Shipley, Martin J., Marmot, Michael G., Davey Smith, George

Objectives. This study examined the association between leisure time physical activity and cause-specific mortality among male Whitehall Study participants with chronic bronchitis.

Socioeconomic Position and Hormone Replacement Therapy Use: Explaining the Discrepancy in Evidence From Observational and Randomized Controlled Trials

Lawlor, Debbie A, Davey Smith, George, Ebrahim, Shah

Objectives. We assessed the association between life-course socioeconomic status or position (SEP) and hormone replacement therapy (HRT).

Life-Course Socioeconomic Position, Area Deprivation, and Coronary Heart Disease: Findings From the British Women’s Heart and Health Study

Lawlor, Debbie A., Davey Smith, George, Patel, Rita, Ebrahim, Shah

Objectives. We sought to determine whether residential area deprivation, over and above the effect of life-course socioeconomic status or position (SEP), is associated with coronary heart disease.

Socioeconomic Position in Childhood and Early Adult Life and Risk of Mortality: A Prospective Study of the Mothers of the 1958 British Birth Cohort

Power, Chris, Hyppönen, Elina, Davey Smith, George

Objectives. We sought to establish whether women’s childhood socioeconomic position influenced their risk of mortality separately from the effects of adult socioeconomic position.

Race/Ethnicity, Income, Major Risk Factors, and Cardiovascular Disease Mortality

Thomas, Avis J., Eberly, Lynn E., Davey Smith, George, Neaton, James D., Stamler, Jeremiah

Objectives. We explored differences between Black and White men for cardiovascular disease (CVD) mortality across major risk factor levels.

Associations Between Income Inequality and Mortality Among US States: The Importance of Time Period and Source of Income Data

Lynch, John, Harper, Sam, Kaplan, George A., Davey Smith, George

Objectives. We used census data to examine associations between income inequality and mortality among US states for each decade from 1949 to 1999 and tax return income data to estimate associations...

Socioeconomic Status and Cardiovascular Disease Among Men: The Korean National Health Service Prospective Cohort Study

Song, Yun-Mi, Ferrer, Robert L., Cho, Sung-il, Sung, Joohon, Ebrahim, Shah, Davey Smith, George

Objectives. We examined the association between socioeconomic status (SES) and myocardial infarction and stroke subtypes, including the possible mediating influence of cardiovascular risk factors.

Alcohol Intake and Blood Pressure: A Systematic Review Implementing a Mendelian Randomization Approach

Chen, Lina, Davey Smith, George, Harbord, Roger M, Lewis, Sarah J

Using a mendelian randomization approach Sarah Lewis and colleagues find strong support for the hypothesis that alcohol intake has a marked effect on blood pressure and the risk of hypertension.

The Mortality Divide in India: The Differential Contributions of Gender, Caste, and Standard of Living Across the Life Course

Subramanian, S.V., Nandy, Shailen, Irving, Michelle, Gordon, Dave, Lambert, Helen, Davey Smith, George

Objectives. We investigated the contributions of gender, caste, and standard of living to inequalities in mortality across the life course in India.

Effect of integration of supplemental nutrition with public health programmes in pregnancy and early childhood on cardiovascular risk in rural Indian adolescents: long term follow-up of Hyderabad nutrition trial

Kinra, Sanjay, Rameshwar Sarma, K V, Mendu, Vishnu Vardhana Rao, Ravikumar, Radhakrishnan, Mohan, Viswanthan, ...

Objective To determine whether integration of nutritional supplementation with other public health programmes in early life reduces the risk of cardiovascular disease in undernourished populations.

Role of socioeconomic markers and state prohibition policy in predicting alcohol consumption among men and women in India: a multilevel statistical analysis.

Subramanian, S. V., Nandy, Shailen, Irving, Michelle, Gordon, David, Davey Smith, George

OBJECTIVE: To investigate the independent contribution of individual socioeconomic markers and state prohibition policy on alcohol consumption among men and women in India. METHODS: The study used a...

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, ...

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist...