George L. Mendz

Characterisation of Campylobacter jejunigenes potentially involved in phosphonate degradation (2009)

Hartley, Lauren E, Kaakoush, Nadeem O, Ford, Justin L, Korolik, Victoria, Mendz, George L

Abstract Potential biological roles of the Campylobacter jejuni genes cj0641, cj0774c and cj1663 were investigated. The proteins encoded by these genes showed sequence similarities to the phosphonate...

Genetic microheterogeneity and phenotypic variation of Helicobacter pyloriarginase in clinical isolates (2007)

Hovey, Justin G, Watson, Emily L, Langford, Melanie L, Hildebrandt, Ellen, Bathala, Sangeetha, Bolland, Jeffrey R, ...

Abstract Background Clinical isolates of the gastric pathogen Helicobacter pylori display a high level of genetic macro- and microheterogeneity, featuring a panmictic, rather than clonal structure....

The Complete Genome Sequence and Analysis of the Epsilonproteobacterium Arcobacter butzleri (2007)

Miller, William G, Parker, Craig T, Rubenfield, Mark, Mendz, George L, Wo, Marc MSM, Ussery, David W, ...

Arcobacter butzleri is a member of the epsilon subdivision of the Proteobacteria and a close taxonomic relative of established pathogens, such as Campylobacter jejuni and Helicobacter pylori. Here we...

Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: A strategy for bacterial survival

Gobert, Alain P., McGee, David J., Akhtar, Mahmood, Mendz, George L., Newton, Jamie C., Cheng, Yulan, ...

The antimicrobial effect of nitric oxide (NO) is an essential part of innate immunity. The vigorous host response to the human gastric pathogen Helicobacter pylori fails to eradicate the organism,...

Helicobacter pylori rocF Is Required for Arginase Activity and Acid Protection In Vitro but Is Not Essential for Colonization of Mice or for Urease Activity

McGee, David J., Radcliff, Fiona J., Mendz, George L., Ferrero, Richard L., Mobley, Harry L. T.

Arginase of the Helicobacter pylori urea cycle hydrolyzes l-arginine to l-ornithine and urea. H. pylori urease hydrolyzes urea to carbon dioxide and ammonium, which neutralizes acid. Both enzymes are...

Metabolism and Genetics of Helicobacter pylori: the Genome Era

Marais, Armelle, Mendz, George L., Hazell, Stuart L., Mégraud, Francis

The publication of the complete sequence of Helicobacter pylori 26695 in 1997 and more recently that of strain J99 has provided new insight into the biology of this organism. In this review, we...

A Novel Mechanism for Resistance to the Antimetabolite N-Phosphonoacetyl-l-Aspartate by Helicobacter pylori

Burns, Brendan P., Mendz, George L., Hazell, Stuart L.

The mechanism of resistance to N-phosphonoacetyl-l-aspartate (PALA), a potent inhibitor of aspartate carbamoyltransferase (which catalyzes the first committed step of de novo pyrimidine...

The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus

Suerbaum, Sebastian, Josenhans, Christine, Sterzenbach, Torsten, Drescher, Bernd, Brandt, Petra, Bell, Monica, ...

Helicobacter hepaticus causes chronic hepatitis and liver cancer in mice. It is the prototype enterohepatic Helicobacter species and a close relative of Helicobacter pylori, also a recognized...

Helicobacter pylori arginase inhibits nitric oxide production by eukaryotic cells: A strategy for bacterial survival

Gobert, Alain P., McGee, David J., Akhtar, Mahmood, Mendz, George L., Newton, Jamie C., Cheng, Yulan, ...

The antimicrobial effect of nitric oxide (NO) is an essential part of innate immunity. The vigorous host response to the human gastric pathogen Helicobacter pylori fails to eradicate the organism,...

Helicobacter pylori rocF Is Required for Arginase Activity and Acid Protection In Vitro but Is Not Essential for Colonization of Mice or for Urease Activity

McGee, David J., Radcliff, Fiona J., Mendz, George L., Ferrero, Richard L., Mobley, Harry L. T.

Arginase of the Helicobacter pylori urea cycle hydrolyzes l-arginine to l-ornithine and urea. H. pylori urease hydrolyzes urea to carbon dioxide and ammonium, which neutralizes acid. Both enzymes are...

Metabolism and Genetics of Helicobacter pylori: the Genome Era

Marais, Armelle, Mendz, George L., Hazell, Stuart L., Mégraud, Francis

The publication of the complete sequence of Helicobacter pylori 26695 in 1997 and more recently that of strain J99 has provided new insight into the biology of this organism. In this review, we...

A Novel Mechanism for Resistance to the Antimetabolite N-Phosphonoacetyl-l-Aspartate by Helicobacter pylori

Burns, Brendan P., Mendz, George L., Hazell, Stuart L.

The mechanism of resistance to N-phosphonoacetyl-l-aspartate (PALA), a potent inhibitor of aspartate carbamoyltransferase (which catalyzes the first committed step of de novo pyrimidine...

The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus

Suerbaum, Sebastian, Josenhans, Christine, Sterzenbach, Torsten, Drescher, Bernd, Brandt, Petra, Bell, Monica, ...

Helicobacter hepaticus causes chronic hepatitis and liver cancer in mice. It is the prototype enterohepatic Helicobacter species and a close relative of Helicobacter pylori, also a recognized...

Roles of α and β Carbonic Anhydrases of Helicobacter pylori in the Urease-Dependent Response to Acidity and in Colonization of the Murine Gastric Mucosa▿

Bury-Moné, Stéphanie, Mendz, George L., Ball, Graham E., Thibonnier, Marie, Stingl, Kerstin, Ecobichon, Chantal, ...

Carbon dioxide occupies a central position in the physiology of Helicobacter pylori owing to its capnophilic nature, the large amounts of carbon dioxide produced by urease-mediated urea hydrolysis,...

Characterisation of Campylobacter jejuni genes potentially involved in phosphonate degradation

Hartley, Lauren E, Kaakoush, Nadeem O, Ford, Justin L, Korolik, Victoria, Mendz, George L

Potential biological roles of the Campylobacter jejuni genes cj0641, cj0774c and cj1663 were investigated. The proteins encoded by these genes showed sequence similarities to the phosphonate...