George L. Spitalny

A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1) (2005)

Repik, Alexander, Pincus, Steve E., Ghiran, Ionita, Nicholson-Weller, Anne, Asher, Damon R., Cerny, Anna M., ...

Complement receptor 1 (CR1) on the surface of human erythrocytes facilitates intravascular clearance of complement-opsonized pathogens. The need for complement activation can be circumvented by...

Actions of Interferons on Macrophages. (2002)

Havell,Edward A., Vogel,Stephanie N., Spitalny,George L.

A rat anti-murine gamma interferon (MuIFN gamma) neutralizing monoclonal antibody (MAB) was used ot investigate the effect of MuIFN gamma on te development of antiviral resistance, Fc receptor...

Heteropolymers: A New Class of Therapeutics for Treating Lethal Bacterial and Viral Infections (1998)

Mohamed, Nehal, Jones, Steven M., Li, Juan, Ferreira, Claudia, Chen, Xun, Kreiswirth, Barry, ...

Heteropolymers (HPs) contain a MAb directed against the Complement Receptor type 1 (CR1) on primate RBCs, chemically cross-linked to MAbs that recognize pathogens. Upon administration of HPs...

Enhancement of Anthrax Lethal Toxin Cytotoxicity: a Subset of Monoclonal Antibodies against Protective Antigen Increases Lethal Toxin-Mediated Killing of Murine Macrophages

Mohamed, Nehal, Li, Juan, Ferreira, Claudia S., Little, Stephen F., Friedlander, Arthur M., Spitalny, George L., ...

We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage...

Enhancement of Anthrax Lethal Toxin Cytotoxicity: a Subset of Monoclonal Antibodies against Protective Antigen Increases Lethal Toxin-Mediated Killing of Murine Macrophages

Mohamed, Nehal, Li, Juan, Ferreira, Claudia S., Little, Stephen F., Friedlander, Arthur M., Spitalny, George L., ...

We investigated the ability of using monoclonal antibodies (MAbs) against anthrax protective antigen (PA), an anthrax exotoxin component, to modulate exotoxin cytotoxic activity on target macrophage...