Stone, Jeremy G., Rolston, Raj K., Ueda, Masumi, Lee, Hyoung-Gon, Richardson, Sandy L., Castellani, Rudy J., ...
Human kallikrein-related peptidase 3 (hK3), also known as prostate-specific antigen (PSA), is a 33 kDa single chain glycoprotein belonging to the kallikrein family of serine proteases. With...
Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches (2009)
Rudy J. Castellani, Xiongwei Zhu, Hyoung-Gon Lee, Mark A. Smith, George Perry
Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Molecular Pathogenesis of Alzheimer's Disease: Reductionist versus Expansionist Approaches. (2009)
Castellani, Rudy J., Zhu, Xiongwei, Lee, Hyoung-Gon, Smith, Mark A., Perry, George
Alzheimer's disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Journal of Bioequivalence & Bioavailability (2009)
Huixiao Hong, George Perry, Fritz Sörgel, Srinubabu Gedela, Sudhakar Akulapalli
What is the Journal of Bioequivalence & Bioavailability (JBB)?Journal of Bioequivalence & Bioavailability(JBB) is a peer reviewed, international, interdisciplinary scholarly open access journal of...
Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
ABSTRACT: Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas alpha-synuclein has been found to be...
Mark A. Smith, George Perry, Xiongwei Zhu, Abdelali Haoudi, Neurodegenerative Diseases, Mark A. Smith, ...
distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Millington, James, Romero-Calcerrada, Raúl, Wainwright, John, Perry, George
Humans have a long history of activity in Mediterranean Basin landscapes. Spatial heterogeneity in these landscapes hinders our understanding about the impacts of changes in human activity on...
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease (2008)
Bryan, Kathryn J, Zhu, Xiongwei, Harris, Peggy L, Perry, George, Castellani, Rudy J, Smith, Mark A, ...
Abstract Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of...
The role of metabotropic glutamate receptors in Alzheimer’s disease (2008)
Neu Obiologi E, Hyoung-gon Lee, Xiongwei Zhu, Michael J. O’neill, Gemma Casadesus, ...
Abstract. While glutamatergic transmission is severely altered by early degeneration of cortico-cortical connections and hippocampal projections in Alzheimer’s disease (AD), the role of glutamate...
Spanel-Borowski, Katharina, Smith, Mark A., Simone, Cristiano, Simonsen, Anne, Simon, Hans-Uwe, ...
Research in autophagy continues to accelerate, and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring...
Thakur, Akanksha, Siedlak, Sandra L, James, Sheronica L, Bonda, David J, Rao, Akanksha, Webber, Kate M, ...
The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitotic pyramidal neurons suggests that neurons in Alzheimer disease (AD) attempt to re-enter the cell...
Pathology's New Role: Defining Disease Process and Protective Responses. (2008)
Perry, George, Castellani, Rudy J, Moreira, Paula I, Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A
Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease (2008)
Rudy J. Castellani, Akihiko Nunomura, Raj K. Rolston, Paula I. Moreira, Atsushi Takeda, George Perry, ...
Although cellular RNA is subjected to the same oxidative insults as DNA and other cellular macromolecules, oxidative damage to RNA has not been a major focus in investigations of the biological...
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease. (2008)
Bryan, Kathryn J, Zhu, Xiongwei, Harris, Peggy L, Perry, George, Castellani, Rudy J, Smith, Mark A, ...
ABSTRACT: Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of...
Teresa A. Evans, Sandra L. Siedlak, Liang Lu, Xiaoming Fu, Zeneng Wang, Woody R. McGinnis, ...
Oxidative damage has been documented in the peripheral tissues of autism patients. In this study, we sought evidence of oxidative injury in autistic brain. Carboxyethyl pyrrole (CEP) and...
Cow Condition and Reproductive Performance (2007)
It has been understood for decades that reproductive performance is the most important factor affecting production efficiency of a cow-calf enterprise. To maintain a yearly calving interval (one calf...
The contribution of luteinizing hormone to Alzheimer disease pathogenesis. (2007)
Webber, Kate M., Perry, George, Smith, Mark A., Casadesus, Gemma
Several hypotheses have been proposed that attempt to explain the pathogenesis of Alzheimer Disease (AD) including theories involving senile plaque and neurofibrillary tangle formation, increased...
Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease. (2007)
Casadesus, Gemma, Smith, Mark A, Basu, Samar, Hua, Jing, Capobianco, Dae E, Siedlak, Sandra L, ...
BACKGROUND: Inflammation and oxidative stress are both involved in the pathogenesis of Alzheimer disease and have been shown to be reciprocally linked. One group of molecules that have been directly...
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease. (2007)
Evans, Teresa A., Raina, Arun K., Delacourte, Andr, Aprelikova, Olga, Lee, Hyoung-gon, Zhu, Xiongwei, ...
In Alzheimer disease, neuronal degeneration and the presence of neurofibrillary tangles correlate with the severity of cognitive decline. Neurofibrillary tangles contain the antigenic profile of many...
The contribution of luteinizing hormone to Alzheimer disease pathogenesis. (2007)
Webber, Kate M., Perry, George, Smith, Mark A., Casadesus, Gemma
Several hypotheses have been proposed that attempt to explain the pathogenesis of Alzheimer Disease (AD) including theories involving senile plaque and neurofibrillary tangle formation, increased...
The Pathology of Alzheimer Disease Elicits an In Vivo Immunological Response (2007)
David J. Bonda, Kate M. Webber, Sandra L. Siedlak, George Perry, Robert P. Friedland, Mark A. Smith
The mechanism(s) responsible for the loss of neurons that characterizes Alzheimer disease is incompletely understood. Nonetheless, there is considerable evidence suggestive of immuneabnormalities...
Targeting gonadotropins: an alternative option for Alzheimer disease treatment. (2006)
Casadesus, Gemma, Puig, Emma Ramiro, Webber, Kate M., Atwood, Craig S., Escuer, Margarida Castell, Bowen, Richard L., ...
Recent evidence indicates that, alongside oxidative stress, dysregulation of the cell cycle in neurons susceptible to degeneration in Alzheimer disease may play a crucial role in the initiation of...
Oxidative damage to RNA in neurodegenerative diseases. (2006)
Nunomura, Akihiko, Honda, Kazuhiro, Takeda, Atsushi, Hirai, Keisuke, Zhu, Xiongwei, Smith, Mark A., ...
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion...
LRRK2 in Parkinson's disease and dementia with Lewy bodies. (2006)
Zhu, Xiongwei, Babar, Asim, Siedlak, Sandra L, Yang, Qiwei, Ito, Genta, Iwatsubo, Takeshi, ...
BACKGROUND: Mutations in LRRK2 encoding leucine-rich repeat kinase 2 are thus far the most frequent genetic cause associated with autosomal dominant and idiopathic Parkinson's disease (PD). To...
Neurodegenerative diseases: mechanisms and therapies. (2006)
Smith, Mark A., Perry, George, Zhu, Xiongwei, Haoudi, Abdelali
Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose! (2006)
Lee, Hyoung-gon, Zhu, Xiongwei, Nunomura, Akihiko, Perry, George, Smith, Mark A.
Webber, Kate M, Stocco, Douglas M, Casadesus, Gemma, Bowen, Richard L, Atwood, Craig S, Previll, Laura A, ...
BACKGROUND: Alzheimer disease (AD) is clinically characterized by progressive memory loss, impairments in behavior, language and visual-spatial skills and ultimately, death. Epidemiological data...
Heme deficiency in Alzheimer's disease: a possible connection to porphyria. (2006)
Dwyer, Barney E., Stone, Meghan L., Zhu, Xiongwei, Perry, George, Smith, Mark A.
Mechanisms that cause Alzheimer's disease (AD), an invariably fatal neurodegenerative disease, are unknown. Important recent data indicate that neuronal heme deficiency may contribute to AD...
Heme Deficiency in Alzheimer's Disease: A Possible Connection to Porphyria (2006)
Barney E. Dwyer, Meghan L. Stone, Xiongwei Zhu, George Perry, Mark A. Smith
Mechanisms that cause Alzheimer's disease (AD), an invariably fatal neurodegenerative disease, are unknown. Important recent data indicate that neuronal heme deficiency may contribute to AD...
Targeting Gonadotropins: An Alternative Option for Alzheimer Disease Treatment (2006)
Gemma Casadesus, Emma Ramiro Puig, Kate M. Webber, Craig S. Atwood, Margarida Castell Escuer, Richard L. Bowen, ...
Recent evidence indicates that, alongside oxidative stress, dysregulation of the cell cycle in neurons susceptible to degeneration in Alzheimer disease may play a crucial role in the initiation of...
Oxidative Damage to RNA in Neurodegenerative Diseases (2006)
Akihiko Nunomura, Kazuhiro Honda, Atsushi Takeda, Keisuke Hirai, Xiongwei Zhu, Mark A. Smith, ...
Since 1999, oxidative damage to RNA molecules has been described in several neurological diseases including Alzheimer's disease, Parkinson's disease, Down syndrome, dementia with Lewy bodies, prion...
Factors Affecting Breeding Success (2005)
Reproductive failure is a major source of economic loss in the beef industry. The majority of this loss occurs because cows do not become pregnant during a defined breeding season. Therefore, the...
Involvement of complex carbohydrate chemistry in Alzheimerâs disease (2005)
Dewitt, David A., Castellani, Rudy J., Perry, George, Smith, Mark A.
The cardinal feature of Alzheimer disease is the extracellular deposition of proteinaceous amyloid-β fibrils as senile plaques. Amyloid-β plays an essential role in disease diagnosis and is...
Staying connected: synapses in Alzheimer disease. (2004)
Lee, Hyoung-gon, Moreira, Paula I., Zhu, Xiongwei, Smith, Mark A., Perry, George
Hypoperfusion, Mitochondria Failure, Oxidative Stress, and Alzheimer Disease. (2003)
Aliev, Gjumrakch, Obrenovich, Mark E., Smith, Mark A., Perry, George
Cash, Adam D., Aliev, Gjumrakch, Siedlak, Sandra L., Nunomura, Akihiko, Fujioka, Hisashi, Zhu, Xiongwei, ...
Biochemical studies show that phosphorylated tau, like that found in paired helical filaments (PHFs), does not promote microtubule assembly leading to the view that PHF formation leads to microtubule...
Hypoperfusion, Mitochondria Failure, Oxidative Stress, and Alzheimer Disease (2003)
Gjumrakch Aliev, Mark E. Obrenovich, Mark A. Smith, George Perry
Alzheimer Disease and Oxidative Stress. (2002)
Perry, George, Cash, Adam D., Smith, Mark A.
Research in Alzheimer disease has recently demonstrated compelling evidence on the importance of oxidative processes in its pathogenesis. Cellular changes show that oxidative stress is an event that...
Alzheimer Disease and Oxidative Stress (2002)
George Perry, Adam D. Cash, Mark A. Smith
Research in Alzheimer disease has recently demonstrated compelling evidence on the importance of oxidative processes in its pathogenesis. Cellular changes show that oxidative stress is an event that...
Hibernation, a model of neuroprotection. (2001)
Zhou, Fang, Zhu, Xiongwei, Castellani, Rudy J., Stimmelmayr, Raphaela, Perry, George, Smith, Mark A., ...
Hibernation, a natural model of tolerance to cerebral ischemia, represents a state of pronounced fluctuation in cerebral blood flow where no brain damage occurs. Numerous neuroprotective aspects may...
Mah, Alex L., Perry, George, Smith, Mark A., Monteiro, Mervyn J.
Mutations in the highly homologous presenilin genes encoding presenilin-1 and presenilin-2 (PS1 and PS2) are linked to early-onset Alzheimer's disease (AD). However, apart from a role in early...
Cynthia Balogh, Josh Chaitin, George Perry
and small quantity generator businesses in King County by providing information and technical assistance to protect human health and the environment. For more information or to order additional...
Zhang, Jing, Perry, George, Smith, Mark A., Robertson, David, Olson, Sandra J., Graham, Doyle G., ...
Oxidative damage, including modification of nucleic acids, may contribute to dopaminergic neurodegeneration in the substantia nigra (SN) of patients with Parkinson's disease (PD). To investigate the...
The High Pressure U.S. Labor Market of the 1990s (1999)
Lawrence F. Katz, Alan B. Krueger, Jeff Kling, Bob Gordon, George Perry, Jim Stock, ...
This paper examines the impact of selected labor market changes on the decline in the unemployment rate in the 1990s. The first section provides an overview of aggregate unemployment trends,...
Astrocytes Regulate Microglial Phagocytosis of Senile Plaque Cores of Alzheimerâs Disease (1998)
Dewitt, David A., Perry, George, Cohen, Mark, Doller, Catherine, Silver, Jerry
We have developed an in vitro model in which isolated senile plaque (SP) cores are presented to rat microglial cells in culture. Microglia rapidly phagocytosed, broke apart, and cleared SP cores....
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. (1997)
Smith, Mark A., Harris, Peggy L. R., Sayre, Lawrence M., Perry, George
Damage from free radicals has been demonstrated in susceptible neuronal populations in cases of Alzheimer disease. In this study, we investigated whether iron, a potent source of the highly reactive...
Senile Plaques and Neurofibrillary Tangles: The Concurrent Lesions of Alzheimerâs Disease (1995)
Dewitt, David A., Proprotnik, Darja, Perry, George, Smith, Mark A.
Glial Cell Extracellular Matrix in Alzheimerâs Disease (1995)
DeWitt, David A, Canning, David R., Perry, George
Many studies have yielded conflicting results regarding the toxicity of AB, the peptide which is the principal component of senile plaques in brains of patients with Alzheimer's disease. Using in...
B-Amyloid of Alzheimer's Disease Induces Reactive Gliosis that Inhibits Axonal Outgrowth (1993)
Dewitt, David A., Canning, David R., McKeon, Robert J., Perry, George, Silver, Jerry, Wujek, Jerome R., ...
Pathological lesions in the brains of patients with Alzheimer's disease (AD) are characterized by dense deposits of the protein ,B-amyloid. The link between the deposition of B-amyloid in senile...
Chondroitin Sulfate Proteoglycans Are Associated with the Lesions of Alzheimer's Disease (1993)
Dewitt, David A., Silver, Jerry, Canning, David R., Perry, George
Chondroitin sulfate proteoglycans (CSPG) are extracellular matrix proteins inhibitory to neurite outgrowth in vitro and correlated with decreased neurite outgrowth after CNS injury. Previously,...
Monty Python's Life of Brian (1979)
Jones, Terry (realización), Monty Python (guión), Biziou, Peter (fotografía), Doyle, Julian (montaje), Burgon, Geoffrey (música), Monty Python (actuación), ...
1-55940-901-0
Smith, Mark A., Zhu, Xiongwei, Lee, Hyoung-gon, Harris, Peggy L.R., Fortino, Anne E., Perry, George, ...
A number of recent studies have suggested that cardiac myocytes, previously considered post-mitotic, re-enter the cell cycle and possess the ability to proliferate with certain pathogenic stimuli. To...
Pathology's New Role: Defining Disease Process and Protective Responses
Perry, George, Castellani, Rudy J, Moreira, Paula I, Lee, Hyoung-gon, Zhu, Xiongwei, Smith, Mark A
Thakur, Akanksha, Siedlak, Sandra L, James, Sheronica L, Bonda, David J, Rao, Akanksha, Webber, Kate M, ...
The re-expression of multiple cell cycle markers representing various cell cycle phases in postmitotic pyramidal neurons suggests that neurons in Alzheimer disease (AD) attempt to re-enter the cell...
Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease
Bryan, Kathryn J, Zhu, Xiongwei, Harris, Peggy L, Perry, George, Castellani, Rudy J, Smith, Mark A, ...
Alzheimer disease (AD) is a chronic neurodegenerative disease that is characterized by progressive memory loss. Pathological markers of AD include neurofibrillary tangles, accumulation of amyloid-β...
Aliev, Gjumrakch, Gasimov, Eldar, Obrenovich, Mark E, Fischbach, Kathryn, Shenk, Justin C, Smith, Mark A, ...
The pathogenesis that is primarily responsible for Alzheimer’s disease (AD) and cerebrovascular accidents (CVA) appears to involve chronic hypoperfusion. We studied the ultrastructural features of...
An Agent-Based Model of Mediterranean Agricultural Land-Use/Cover Change for Examining Wildfire Risk
James Millington, Raúl Romero-Calcerrada, John Wainwright, George Perry
Humans have a long history of activity in Mediterranean Basin landscapes. Spatial heterogeneity in these landscapes hinders our understanding about the impacts of changes in human activity on...
Chan, Hsien W., Liu, Tianbing, Verdile, Giuseppe, Bishop, Glenda, Haasl, Ryan J., Smith, Mark A., ...
The basic mechanism(s) by which altered Cu homeostasis is toxic to hepatocytes and neurons, the two major cell types affected in copper storage diseases such as Wilson's disease (WD), remain unclear....
Stone, Jeremy G., Rolston, Raj K., Ueda, Masumi, Lee, Hyoung-Gon, Richardson, Sandy L., Castellani, Rudy J., ...
Human kallikrein-related peptidase 3 (hK3), also known as prostate-specific antigen (PSA), is a 33 kDa single chain glycoprotein belonging to the kallikrein family of serine proteases. With...
Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease
Castellani, Rudy J., Nunomura, Akihiko, Rolston, Raj K., Moreira, Paula I., Takeda, Atsushi, Perry, George, ...
Although cellular RNA is subjected to the same oxidative insults as DNA and other cellular macromolecules, oxidative damage to RNA has not been a major focus in investigations of the biological...
Molecular Pathogenesis of Alzheimer’s Disease: Reductionist versus Expansionist Approaches
Castellani, Rudy J., Zhu, Xiongwei, Lee, Hyoung-Gon, Smith, Mark A., Perry, George
Alzheimer’s disease (AD) is characterized clinically by dementia and pathologically by two hallmark lesions, senile plaques and neurofibrillary tangles. About a quarter century ago these hallmark...
Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease
Su, Bo, Liu, Haihua, Wang, Xinglong, Chen, Shu G, Siedlak, Sandra L, Kondo, Eisaku, ...
Lewy bodies and Lewy neurites constitute the cardinal neuropathological features of both Parkinson's disease (PD) and Lewy body dementia (LBD). Whereas α-synuclein has been found to be the major...
Antibodies to Potato Virus Y Bind the Amyloid β Peptide: IMMUNOHISTOCHEMICAL AND NMR STUDIES*
Friedland, Robert P., Tedesco, Johnathan M., Wilson, Andrea C., Atwood, Craig S., Smith, Mark A., Perry, George, ...
Studies in transgenic mice bearing mutated human Alzheimer disease (AD) genes show that active vaccination with the amyloid β (Aβ) protein or passive immunization with anti-Aβ antibodies has...
The Neuronal Expression of MYC Causes a Neurodegenerative Phenotype in a Novel Transgenic Mouse
Lee, Hyoung-gon, Casadesus, Gemma, Nunomura, Akihiko, Zhu, Xiongwei, Castellani, Rudy J., Richardson, Sandy L., ...
Many different proteins associated with the cell cycle, including cyclins, cyclin-dependent kinases, and proto-oncogenes such as c-MYC (MYC), are increased in degenerating neurons. Consequently, an...