George S. Sheppard

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605 (2009)

Pappano, William N, Jung, Paul M, Meulbroek, Jonathan A, Wang, Yi-Chun, Hubbard, Robert D, Zhang, Qian, ...

Abstract Background The insulin-like growth factor (IGF) axis is an important signaling pathway in the growth and survival of many cell and tissue types. This pathway has also been implicated in many...

Correlation of tumor growth suppression and methionine aminopetidase-2 activity blockade using an orally active inhibitor

Wang, Jieyi, Tucker, Lora A., Stavropoulos, Jason, Zhang, Qian, Wang, Yi-Chun, Bukofzer, Gail, ...

This laboratory and others have shown that agents that inhibit the in vitro catalytic activity of methionine aminopeptidase-2 (MetAP2) are effective in blocking angiogenesis and tumor growth in...

Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605

Pappano, William N, Jung, Paul M, Meulbroek, Jonathan A, Wang, Yi-Chun, Hubbard, Robert D, Zhang, Qian, ...