IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis
Grabie, Nir, Delfs, Michael W., Westrich, Jason R., Love, Victoria A., Stavrakis, George, Ahmad, Ferhaan, ...
Cardiac antigen–specific CD8+ T cells are involved in the autoimmune component of human myocarditis. Here, we studied the differentiation and migration of pathogenic CD8+ T cell effector cells in a...
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses
Buono, Chiara, Binder, Christoph J., Stavrakis, George, Witztum, Joseph L., Glimcher, Laurie H., Lichtman, Andrew H.
The influence of the immune system on atherosclerosis involves both helper T (Th) cell and antibody responses to plaque antigens. These responses may have proatherogenic and protective effects. T-bet...
Vielhauer, Volker, Stavrakis, George, Mayadas, Tanya N.
TNF is essential for the development of glomerulonephritis, an immune-mediated disorder that is a major cause of renal failure worldwide. However, TNF has proinflammatory and immunosuppressive...
IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis
Grabie, Nir, Delfs, Michael W., Westrich, Jason R., Love, Victoria A., Stavrakis, George, Ahmad, Ferhaan, ...
Cardiac antigen–specific CD8+ T cells are involved in the autoimmune component of human myocarditis. Here, we studied the differentiation and migration of pathogenic CD8+ T cell effector cells in a...
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses
Buono, Chiara, Binder, Christoph J., Stavrakis, George, Witztum, Joseph L., Glimcher, Laurie H., Lichtman, Andrew H.
The influence of the immune system on atherosclerosis involves both helper T (Th) cell and antibody responses to plaque antigens. These responses may have proatherogenic and protective effects. T-bet...
Vielhauer, Volker, Stavrakis, George, Mayadas, Tanya N.
TNF is essential for the development of glomerulonephritis, an immune-mediated disorder that is a major cause of renal failure worldwide. However, TNF has proinflammatory and immunosuppressive...
Early Adaptive Responses of the Vascular Wall during Venous Arterialization in Mice
Kwei, Stephanie, Stavrakis, George, Takahas, Masaya, Taylor, George, Folkman, M. Judah, Gimbrone, Michael A., ...
Venous arterialization occurs when a vein segment is transposed as a bypass graft into the arterial circulation, resulting in a structural and functional reorganization of the vascular wall in...
Neutrophils Sustain Pathogenic CD8+ T Cell Responses in the Heart
Grabie, Nir, Hsieh, Dennis T., Buono, Chiara, Westrich, Jason R., Allen, Jessica A., Pang, Hong, ...
This study explores the influence of innate immunity on CD8+ T-cell responses against heart tissue. Adoptive transfer of ovalbumin-specific CD8+ effector T cells into CMy-mOva mice, which express...
Stokol, Tracy, O'Donnell, Peter, Xiao, Ling, Knight, Sara, Stavrakis, George, Botto, Marina, ...
Inflammation induced by circulating immunoglobulin G–immune complexes (ICs) characterizes many immune-mediated diseases. In this work, the molecular requirements for the deposition of circulating...