Georges Snounou

Effective and cheap removal of leukocytes and platelets from Plasmodium vivaxinfected blood (2009)

Sriprawat, Kanlaya, Kaewpongsri, Supaporn, Suwanarusk, Rossarin, Leimanis, Mara L, Lek-Uthai, Usa, Phyo, Aung, ...

Abstract Background Investigations of Plasmodium vivax are restricted to samples collected from infected persons or primates, because this parasite cannot be maintained in in vitro cultures....

A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages (2006)

Maëlle Carraz, Akino Jossang, Jean-François Franetich, Anthony Siau, Liliane Ciceron, Laurent Hannoun, ...

BackgroundThe global spread of multidrug–resistant malaria parasites has led to an urgent need for new chemotherapeutic agents. Drug discovery is primarily directed to the asexual blood stages, and...

Practical PCR genotyping protocols for Plasmodium vivaxusing Pvcsand Pvmsp1 (2005)

Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...

Abstract Background Plasmodium vivax is the second most prevalent malaria parasite affecting more than 75 million people each year, mostly in South America and Asia. In addition to major morbidity...

Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1. (2005)

Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne Charlotte, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...

BACKGROUND: Plasmodium vivax is the second most prevalent malaria parasite affecting more than 75 million people each year, mostly in South America and Asia. In addition to major morbidity this...

Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1. (2005)

Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne Charlotte, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...

BACKGROUND: Plasmodium vivax is the second most prevalent malaria parasite affecting more than 75 million people each year, mostly in South America and Asia. In addition to major morbidity this...

Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1. (2005)

Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne Charlotte, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...

BACKGROUND: Plasmodium vivax is the second most prevalent malaria parasite affecting more than 75 million people each year, mostly in South America and Asia. In addition to major morbidity this...

Practical PCR genotyping protocols for Plasmodium vivax using Pvcs and Pvmsp1. (2005)

Imwong, Mallika, Pukrittayakamee, Sasithon, Grüner, Anne Charlotte, Rénia, Laurent, Letourneur, Frank, Looareesuwan, Sornchai, ...

BACKGROUND: Plasmodium vivax is the second most prevalent malaria parasite affecting more than 75 million people each year, mostly in South America and Asia. In addition to major morbidity this...

MEIOTIC RECOMBINATION, CROSS-REACTIVITY, AND PERSISTENCE IN PLASMODIUM FALCIPARUM (2001)

F. Ellis McKenzie, Marcelo U. Ferreira, J. Kevin Baird, Georges Snounou, William H. Bossert

We incorporate a representation of Plasmodium falciparum recombination within a discrete-event model of malaria transmission. We simulate the introduction of a new parasite genotype into a human...

Influence of polymorphism in the genes for the interleukin (IL)-1 receptor antagonist and IL-1beta on tuberculosis. (1999)

Wilkinson, Robert J., Patel, Punita, Llewelyn, Martin, Hirsch, Christina S., Pasvol, Geoffrey, Snounou, Georges, ...

Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. The proinflammatory cytokine interleukin (IL)-1beta and...

Association of Genetic Mutations in Plasmodium vivax dhfr with Resistance to Sulfadoxine-Pyrimethamine: Geographical and Clinical Correlates

Imwong, Mallika, Pukrittakayamee, Sasithon, Looareesuwan, Sornchai, Pasvol, Geoffrey, Poirreiz, Jean, White, Nicholas J., ...

Mutations in the Plasmodium falciparum gene (dhfr) encoding dihydrofolate reductase are associated with resistance to antifols. Plasmodium vivax, the more prevalent malaria parasite in Asia and the...

Only Viable Parasites Are Detected by PCR following Clearance of Rodent Malarial Infections by Drug Treatment or Immune Responses

Jarra, William, Snounou, Georges

Detection and analysis of pathogens by PCR plays an important role in infectious disease research. The value of these studies would be diminished if nuclear material from dead parasites were found to...

Novel Point Mutations in the Dihydrofolate Reductase Gene of Plasmodium vivax: Evidence for Sequential Selection by Drug Pressure

Imwong, Mallika, Pukrittayakamee, Sasithon, Rénia, Laurent, Letourneur, Franck, Charlieu, Jean-Paul, Leartsakulpanich, Ubolsree, ...

Mutations in the dihydrofolate reductase (dhfr) genes of Plasmodium falciparum and P. vivax are associated with resistance to the antifolate antimalarial drugs. P. vivax dhfr sequences were obtained...

Resistance and Susceptibility to Filarial Infection with Litomosoides sigmodontis Are Associated with Early Differences in Parasite Development and in Localized Immune Reactions

Babayan, Simon, Ungeheuer, Marie-Noëlle, Martin, Coralie, Attout, Tarik, Belnoue, Elodie, Snounou, Georges, ...

In order to understand natural resistance to filariasis, we compared Litomosoides sigmodontis primary infection of C57BL/6 mice, which eliminate the worms before patency, and BALB/c mice, in which...

Species-Specific Inhibition of Cerebral Malaria in Mice Coinfected with Plasmodium spp.

Voza, Tatiana, Vigário, Ana M., Belnoue, Elodie, Grüner, Anne Charlotte, Deschemin, Jean-Christophe, Kayibanda, Michèle, ...

Recent epidemiological observations suggest that clinical evolution of Plasmodium falciparum infections might be influenced by the concurrent presence of another Plasmodium species, and such...

Limited Polymorphism in the Dihydropteroate Synthetase Gene (dhps) of Plasmodium vivax Isolates from Thailand

Imwong, Mallika, Pukrittayakamee, Sasithon, Cheng, Qin, Moore, Catrin, Looareesuwan, Sornchai, Snounou, Georges, ...

The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of...

Association of Genetic Mutations in Plasmodium vivax dhfr with Resistance to Sulfadoxine-Pyrimethamine: Geographical and Clinical Correlates

Imwong, Mallika, Pukrittakayamee, Sasithon, Looareesuwan, Sornchai, Pasvol, Geoffrey, Poirreiz, Jean, White, Nicholas J., ...

Mutations in the Plasmodium falciparum gene (dhfr) encoding dihydrofolate reductase are associated with resistance to antifols. Plasmodium vivax, the more prevalent malaria parasite in Asia and the...

Only Viable Parasites Are Detected by PCR following Clearance of Rodent Malarial Infections by Drug Treatment or Immune Responses

Jarra, William, Snounou, Georges

Detection and analysis of pathogens by PCR plays an important role in infectious disease research. The value of these studies would be diminished if nuclear material from dead parasites were found to...

Novel Point Mutations in the Dihydrofolate Reductase Gene of Plasmodium vivax: Evidence for Sequential Selection by Drug Pressure

Imwong, Mallika, Pukrittayakamee, Sasithon, Rénia, Laurent, Letourneur, Franck, Charlieu, Jean-Paul, Leartsakulpanich, Ubolsree, ...

Mutations in the dihydrofolate reductase (dhfr) genes of Plasmodium falciparum and P. vivax are associated with resistance to the antifolate antimalarial drugs. P. vivax dhfr sequences were obtained...

Resistance and Susceptibility to Filarial Infection with Litomosoides sigmodontis Are Associated with Early Differences in Parasite Development and in Localized Immune Reactions

Babayan, Simon, Ungeheuer, Marie-Noëlle, Martin, Coralie, Attout, Tarik, Belnoue, Elodie, Snounou, Georges, ...

In order to understand natural resistance to filariasis, we compared Litomosoides sigmodontis primary infection of C57BL/6 mice, which eliminate the worms before patency, and BALB/c mice, in which...

Species-Specific Inhibition of Cerebral Malaria in Mice Coinfected with Plasmodium spp.

Voza, Tatiana, Vigário, Ana M., Belnoue, Elodie, Grüner, Anne Charlotte, Deschemin, Jean-Christophe, Kayibanda, Michèle, ...

Recent epidemiological observations suggest that clinical evolution of Plasmodium falciparum infections might be influenced by the concurrent presence of another Plasmodium species, and such...

Limited Polymorphism in the Dihydropteroate Synthetase Gene (dhps) of Plasmodium vivax Isolates from Thailand

Imwong, Mallika, Pukrittayakamee, Sasithon, Cheng, Qin, Moore, Catrin, Looareesuwan, Sornchai, Snounou, Georges, ...

The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A → G) in 33 isolates, all from Thailand. Mutations of...

A Plant-Derived Morphinan as a Novel Lead Compound Active against Malaria Liver Stages

Carraz, Maëlle, Jossang, Akino, Franetich, Jean-François, Siau, Anthony, Ciceron, Liliane, Hannoun, Laurent, ...

A derivative of a morphinan alkaloid, tazopsine, from a plant used against malaria in Madagascar, is active against the hepatic stages ofPlasmodium species.

Plasmodium sporozoites trickle out of the injection site

Yamauchi, Lucy Megumi, Coppi, Alida, Snounou, Georges, Sinnis, Photini

Plasmodium sporozoites make a remarkable journey from the skin, where they are deposited by an infected Anopheline mosquito, to the liver, where they invade hepatocytes and develop into...

Environmental influence on the genetic basis of mosquito resistance to malaria parasites

Lambrechts, Louis, Chavatte, Jean-Marc, Snounou, Georges, Koella, Jacob C

The genetic basis of a host's resistance to parasites has important epidemiological and evolutionary consequences. Understanding this genetic basis can be complicated by non-genetic factors, such as...

Genetic Analysis of the Dihydrofolate Reductase-Thymidylate Synthase Gene from Geographically Diverse Isolates of Plasmodium malariae▿

Tanomsing, Naowarat, Imwong, Mallika, Pukrittayakamee, Sasithon, Chotivanich, Kesinee, Looareesuwan, Sornchai, Mayxay, Mayfong, ...

Plasmodium malariae, the parasite responsible for quartan malaria, is transmitted in most areas of malaria endemicity and is associated with significant morbidity. The sequence of the gene coding for...

Influence of Polymorphism in the Genes for the Interleukin (IL)-1 Receptor Antagonist and IL-1β on Tuberculosis

Wilkinson, Robert J., Patel, Punita, Llewelyn, Martin, Hirsch, Christina S., Pasvol, Geoffrey, Snounou, Georges, ...

Several lines of evidence suggest that host genetic factors controlling the immune response influence infection by Mycobacterium tuberculosis. The proinflammatory cytokine interleukin (IL)-1β and...

Temperature Shift and Host Cell Contact Up-Regulate Sporozoite Expression of Plasmodium falciparum Genes Involved in Hepatocyte Infection

Siau, Anthony, Silvie, Olivier, Franetich, Jean-François, Yalaoui, Samir, Marinach, Carine, Hannoun, Laurent, ...

Plasmodium sporozoites are deposited in the skin by Anopheles mosquitoes. They then find their way to the liver, where they specifically invade hepatocytes in which they develop to yield merozoites...

A Role for Immune Responses against Non-CS Components in the Cross-Species Protection Induced by Immunization with Irradiated Malaria Sporozoites

Mauduit, Marjorie, Grüner, Anne Charlotte, Tewari, Rita, Depinay, Nadya, Kayibanda, Michèle, Chavatte, Jean-Marc, ...

Immunization with irradiated Plasmodium sporozoites induces sterile immunity in rodents, monkeys and humans. The major surface component of the sporozoite the circumsporozoite protein (CS) long...