Georgia Panopoulou

Monte Carlo analysis of an ODE Model of the Sea Urchin Endomesoderm Network (2009)

Kühn, Clemens, Wierling, Christoph, Kühn, Alexander, Klipp, Edda, Panopoulou, Georgia, Lehrach, Hans, ...

Abstract Background Gene Regulatory Networks (GRNs) control the differentiation, specification and function of cells at the genomic level. The levels of interactions within large GRNs are of enormous...

Deeply conserved chordate noncoding sequences preserve genome synteny but do not drive gene duplicate retention (2009)

Hufton, Andrew L., Mathia, Susanne, Braun, Helene, Georgi, Udo, Lehrach, Hans, Vingron, Martin, ...

Animal genomes possess highly conserved cis-regulatory sequences that are often found near genes that regulate transcription and development. Researchers have proposed that the strong conservation of...

GOblet: Annotation of anonymous sequence data with Gene Ontology and Pathway terms (2008)

Groth, Detlef, Hartmann, Stefanie, Panopoulou, Georgia, Poustka, Albert J., Hennig, Steffen

The functional annotation of genomic data has become a major task for the ever-growing number of sequencing projects. In order to address this challenge, we recently developed GOblet, a free web...

Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement (2008)

Hufton, Andrew L., Groth, Detlef, Vingron, Martin, Lehrach, Hans, Poustka, Albert, Panopoulou, Georgia

Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important...

GOblet : annotation of anonymous sequence data with Gene Ontology and pathway terms (2008)

Groth, Detlef, Hartmann, Stefanie, Panopoulou, Georgia, Poustka, Albert J., Hennig, Steffen

The functional annotation of genomic data has become a major task for the ever-growing number of sequencing projects. In order to address this challenge, we recently developed GOblet, a free web...

Evolution of a core gene network for skeletogenesis in chordates (2008)

Hecht, Jochen, Stricker, Sigmar, Wiecha, Ulrike, Stiege, Asita, Panopoulou, Georgia, Podsiadlowski, Lars, ...

The skeleton is one of the most important features for the reconstruction of vertebrate phylogeny but few data are available to understand its molecular origin. In mammals the Runt genes are central...

Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement (2008)

Hufton, Andrew L., Groth, Detlef, Vingron, Martin, Lehrach, Hans, Poustka, Albert J., Panopoulou, Georgia

Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important...

Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement (2008)

Hufton, Andrew L., Groth, Detlef, Vingron, Martin, Lehrach, Hans, Poustka, Albert J., Panopoulou, Georgia

Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important...

A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks (2007)

Poustka, Albert J, Kühn, Alexander, Groth, Detlef, Weise, Vesna, Yaguchi, Shunsuke, Burke, Robert D, ...

Abstract Background The genome of the sea urchin Strongylocentrotus purpuratus has recently been sequenced because it is a major model system for the study of gene regulatory networks. Embryonic...

A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks (2007)

Poustka, Albert J., Kühn, Alexander, Groth, Detlef, Weise, Vesna, Yaguchi, Shunsuke, Burke, Robert D., ...

Background The genome of the sea urchin Strongylocentrotus purpuratus has recently been sequenced because it is a major model system for the study of gene regulatory networks. Embryonic expression...

Timing and mechanism of ancient vertebrate genome duplications – the adventure of a hypothesis (2005)

Panopoulou, Georgia, Poustka, Albert J.

Complete genome doubling has long-term consequences for the genome structure and the subsequent evolution of an organism. It has been suggested that two genome duplications occurred at the origin of...

On the origin of the chordate central nervous system : expression of onecut in the sea urchin embryo (2004)

Poustka,Albert J., Kühn,Alexander, Radosavljevic,Vesna, Wellenreuther,Ruth, Lehrach,Hans, Panopoulou,Georgia

We identified a transcription factor of the onecut class in the sea urchin Strongylocentrotus purpuratus that represents an ortholog of the mammalian gene HNF6, the founding member of the onecut...

On the origin of the chordate central nervous system : expression of onecut in the sea urchin embryo (2004)

Poustka, Albert J., Kühn, Alexander, Radosavljevic, Vesna, Wellenreuther, Ruth, Lehrach, Hans, Panopoulou, Georgia

We identified a transcription factor of the onecut class in the sea urchin Strongylocentrotus purpuratus that represents an ortholog of the mammalian gene HNF6, the founding member of the onecut...

Generation, annotation, evolutionary analysis, and database integration of 20,000 unique sea urchin EST clusters (2003)

Poustka,Albert J., Groth,Detlef, Hennig,Steffen, Thamm,Sabine, Cameron,Andrew, Beck,Alfred, ...

Together with the hemichordates, sea urchins represent basal groups of nonchordate invertebrate deuterostomes that occupy a key position in bilaterian evolution. Because sea urchin embryos are also...

The amphioxus Hairy family: differential fate after duplication (2003)

Minguillon,Carolina, Jimenez-Delgado,Senda, Panopoulou,Georgia, Garcia-Fernandez,Jordi

Vertebrate Hairy genes are highly pleiotropic and have been implicated in numerous functions, such as somitogenesis, neurogenesis and endocrine tissue development. In order to gain insight into the...

New evidence for genome-wide duplications at the origin of vertebrates using an amphioxus gene set and completed animal genomes (2003)

Panopoulou,Georgia, Hennig,Steffen, Groth,Detlef, Krause,Antje, Poustka,Albert J., Herwig,Ralf, ...

The 2R hypothesis predicting two genome duplications at the origin of vertebrates is highly controversial. Studies published so far include limited sequence data from organisms close to the...

Generation, annotation, evolutionary analysis, and database integration of 20,000 unique sea urchin EST clusters (2003)

Poustka, Albert J., Groth, Detlef, Hennig, Steffen, Thamm, Sabine, Cameron, Andrew, Beck, Alfred, ...

Together with the hemichordates, sea urchins represent basal groups of nonchordate invertebrate deuterostomes that occupy a key position in bilaterian evolution. Because sea urchin embryos are also...

The amphioxus Hairy family: differential fate after duplication (2003)

Minguillon, Carolina, Jimenez-Delgado, Senda, Panopoulou, Georgia, Garcia-Fernandez, Jordi

Vertebrate Hairy genes are highly pleiotropic and have been implicated in numerous functions, such as somitogenesis, neurogenesis and endocrine tissue development. In order to gain insight into the...

New evidence for genome-wide duplications at the origin of vertebrates using an amphioxus gene set and completed animal genomes (2003)

Panopoulou, Georgia, Hennig, Steffen, Groth, Detlef, Krause, Antje, Poustka, Albert J., Herwig, Ralf, ...

The 2R hypothesis predicting two genome duplications at the origin of vertebrates is highly controversial. Studies published so far include limited sequence data from organisms close to the...

New Evidence for Genome-Wide Duplications at the Origin of Vertebrates Using an Amphioxus Gene Set and Completed Animal Genomes (2003)

Panopoulou, Georgia, Hennig, Steffen, Groth, Detlef, Krause, Antje, Poustka, Albert J., Herwig, Ralf, ...

The 2R hypothesis predicting two genome duplications at the origin of vertebrates is highly controversial. Studies published so far include limited sequence data from organisms close to the...

Generation, Annotation, Evolutionary Analysis, and Database Integration of 20,000 Unique Sea Urchin EST Clusters (2003)

Poustka, Albert J., Groth, Detlef, Hennig, Steffen, Thamm, Sabine, Cameron, Andrew, Beck, Alfred, ...

Together with the hemichordates, sea urchins represent basal groups of nonchordate invertebrate deuterostomes that occupy a key position in bilaterian evolution. Because sea urchin embryos are also...

New Evidence for Genome-Wide Duplications at the Origin of Vertebrates Using an Amphioxus Gene Set and Completed Animal Genomes

Panopoulou, Georgia, Hennig, Steffen, Groth, Detlef, Krause, Antje, Poustka, Albert J., Herwig, Ralf, ...

The 2R hypothesis predicting two genome duplications at the origin of vertebrates is highly controversial. Studies published so far include limited sequence data from organisms close to the...

Generation, Annotation, Evolutionary Analysis, and Database Integration of 20,000 Unique Sea Urchin EST Clusters

Poustka, Albert J., Groth, Detlef, Hennig, Steffen, Thamm, Sabine, Cameron, Andrew, Beck, Alfred, ...

Together with the hemichordates, sea urchins represent basal groups of nonchordate invertebrate deuterostomes that occupy a key position in bilaterian evolution. Because sea urchin embryos are also...

New Evidence for Genome-Wide Duplications at the Origin of Vertebrates Using an Amphioxus Gene Set and Completed Animal Genomes

Panopoulou, Georgia, Hennig, Steffen, Groth, Detlef, Krause, Antje, Poustka, Albert J., Herwig, Ralf, ...

The 2R hypothesis predicting two genome duplications at the origin of vertebrates is highly controversial. Studies published so far include limited sequence data from organisms close to the...

Generation, Annotation, Evolutionary Analysis, and Database Integration of 20,000 Unique Sea Urchin EST Clusters

Poustka, Albert J., Groth, Detlef, Hennig, Steffen, Thamm, Sabine, Cameron, Andrew, Beck, Alfred, ...

Together with the hemichordates, sea urchins represent basal groups of nonchordate invertebrate deuterostomes that occupy a key position in bilaterian evolution. Because sea urchin embryos are also...

A global view of gene expression in lithium and zinc treated sea urchin embryos: new components of gene regulatory networks

Poustka, Albert J, Kühn, Alexander, Groth, Detlef, Weise, Vesna, Yaguchi, Shunsuke, Burke, Robert D, ...

Novel territory-specific markers from the sea urchin Strongylocentrotus purpuratus have been identified using screens for genes that are differentially expressed in lithium-treated embryos, which...

Evolution of a Core Gene Network for Skeletogenesis in Chordates

Hecht, Jochen, Stricker, Sigmar, Wiecha, Ulrike, Stiege, Asita, Panopoulou, Georgia, Podsiadlowski, Lars, ...

The skeleton is one of the most important features for the reconstruction of vertebrate phylogeny but few data are available to understand its molecular origin. In mammals the Runt genes are central...

Early vertebrate whole genome duplications were predated by a period of intense genome rearrangement

Hufton, Andrew L., Groth, Detlef, Vingron, Martin, Lehrach, Hans, Poustka, Albert J., Panopoulou, Georgia

Researchers, supported by data from polyploid plants, have suggested that whole genome duplication (WGD) may induce genomic instability and rearrangement, an idea which could have important...