Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations (2009)
Salanti, Georgia, Southam, Lorraine, Altshuler, David, Ardlie, Kristin, Barroso, Inês, Boehnke, Michael, ...
For most associations of common single nucleotide polymorphisms (SNPs) with common diseases, the genetic model of inheritance is unknown. The authors extended and applied a Bayesian meta-analysis...
Discovery Properties of Genome-wide Association Signals From Cumulatively Combined Data Sets (2009)
Pereira, Tiago V., Patsopoulos, Nikolaos A., Salanti, Georgia, Ioannidis, John P. A.
Genetic effects for common variants affecting complex disease risk are subtle. Single genome-wide association (GWA) studies are typically underpowered to detect these effects, and combination of...
Mauri, Davide, Polyzos, Nikolaos P., Salanti, Georgia, Pavlidis, Nicholas, Ioannidis, John P. A.
Background Many systemic nonhormonal regimens have been evaluated across several hundreds of randomized trials in advanced breast cancer. We aimed to quantify the relative merits of these regimens in...
Sagoo, Gurdeep S., Tatt, Iain, Salanti, Georgia, Butterworth, Adam S., Sarwar, Nadeem, Van Maarle, Merel, ...
Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism and a major candidate gene for coronary heart disease (CHD). The authors assessed associations between 7 LPL polymorphisms and lipid...
Higgins, Julian P. T., Little, Julian, Ioannidis, John P. A., Bray, Molly S., Manolio, Teri A., Smeeth, Liam, ...
Sanderson, Simon, Salanti, Georgia, Higgins, Julian
Bladder cancer is an increasingly important international public health problem, with over 330,000 new cases being diagnosed each year worldwide. In a systematic review and evidence synthesis, the...
Kyrgiou, Maria, Salanti, Georgia, Pavlidis, Nicholas, Paraskevaidis, Evangelos, Ioannidis, John P. A.
Background: Numerous randomized trials have compared different chemotherapy regimens in women with ovarian cancer. Although ovarian cancer survival has improved in recent years, the magnitude of...
Family-Based versus Unrelated Case-Control Designs for Genetic Associations (2006)
Evangelos Evangelou, Thomas A. Trikalinos, Georgia Salanti
The most simple and commonly used approach for genetic associations is the case-control study design of unrelated people. This design is susceptible to population stratification. This problem is...
Family-based vs. unrelated case-control designs for genetic associations (2006)
Evangelos Evangelou, Thomas Trikalinos, Georgia Salanti
The most simple and commonly used approach for genetic associations is the case-control study design of unrelated subjects. This design is susceptible to population stratification. This problem is...
Trikalinos, Thomas A., Salanti, Georgia, Khoury, Muin J., Ioannidis, John P. A.
The authors evaluated whether statistically significant violations of Hardy-Weinberg equilibrium (HWE) or the magnitude of deviations from HWE may contribute to the problem of replicating postulated...
A non-parametric framework for estimating threshold limit values (2005)
Abstract Background To estimate a threshold limit value for a compound known to have harmful health effects, an 'elbow' threshold model is usually applied. We are interested on non-parametric...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
Gilbert, Ruth, Salanti, Georgia, Harden, Melissa, See, Sarah
Background Before the early 1990s, parents were advised to place infants to sleep on their front contrary to evidence from clinical research. Methods We systematically reviewed associations between...
Gilbert, Ruth, Salanti, Georgia, Harden, Melissa, See, Sarah
Background Before the early 1990s, parents were advised to place infants to sleep on their front contrary to evidence from clinical research. Methods We systematically reviewed associations between...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
A Network of Investigator Networks in Human Genome Epidemiology (2005)
Ioannidis, John P. A., Bernstein, Jonine, Boffetta, Paolo, Danesh, John, Dolan, Siobhan, Hartge, Patricia, ...
The task of identifying genetic determinants for complex, multigenetic diseases is hampered by small studies, publication and reporting biases, and lack of common standards worldwide. The authors...
The Isotonic Regression Framework (2003)
Categorizing continuous variables arises as an important task in statistical analysis, especially in analyzing dose-response relationships. Creating meaningful groups of the predictor variables...
The Isotonic Regression Framework (2003)
Categorizing continuous variables arises as an important task in statistical analysis, especially in analyzing dose-response relationships. Creating meaningful groups of the predictor variables...
The isotonic regression framework : estimating and testing under order restrictions / (2003)
München, Univ., Diss, 2003 (Nur beschränkt für den Austausch).
Multidimensional isotonic regression and estimation of
Family-Based versus Unrelated Case-Control Designs for Genetic Associations
Evangelou, Evangelos, Trikalinos, Thomas A, Salanti, Georgia, Ioannidis, John P. A
The most simple and commonly used approach for genetic associations is the case-control study design of unrelated people. This design is susceptible to population stratification. This problem is...
Family-Based versus Unrelated Case-Control Designs for Genetic Associations
Evangelou, Evangelos, Trikalinos, Thomas A, Salanti, Georgia, Ioannidis, John P. A
The most simple and commonly used approach for genetic associations is the case-control study design of unrelated people. This design is susceptible to population stratification. This problem is...