Gerald Thiel

Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+concentration, phosphorylation of ERK and activation of ternary complex factor (2009)

Rössler, Oliver G, Thiel, Gerald

Abstract Background The serine protease thrombin catalyzes fibrin clot formation by converting fibrinogen into fibrin. Additionally, thrombin stimulation leads to an activation of stimulus-responsive...

Regulation of cellular proliferation, differentiation and cell death by activated Raf (2009)

Thiel, Gerald, Ekici, Myriam, Rössler, Oliver G

Abstract The protein kinases Raf-1, A-Raf and B-Raf connect receptor stimulation with intracellular signaling pathways and function as a central intermediate in many signaling pathways....

Signal Transduction in the Footsteps of Goethe and Schiller (2009)

Friedrich, Karlheinz, Lindquist, Jonathan A, Entschladen, Frank, Serfling, Edgar, Thiel, Gerald, Kieser, Arnd, ...

Abstract The historical town of Weimar in Thuringia, the "green heart of Germany" was the sphere of Goethe and Schiller, the two most famous representatives of German literature's classic era. Not...

Tissue-specific regulatory network extractor (TS-REX): a database and software resource for the tissue and cell type-specific investigation of transcription factor-gene networks (2009)

Colecchia, Federico, Kottwitz, Denise, Wagner, Mandy, Pfenninger, Cosima V., Thiel, Gerald, Tamm, Ingo, ...

The prediction of transcription factor binding sites in genomic sequences is in principle very useful to identify upstream regulatory factors. However, when applying this concept to genomes of...

Transcription of genes encoding synaptic vesicle proteins in human neural stem cells - Chromatin accessibility, histone methylation pattern, and the essential role of rest (2008)

Hohl, Mathias, Martinez-Serrano, Alberto, Thiel, Gerald

Human HNSC. 100 neural stem cells up-regulate expression of GFAP following withdrawal of mitogens. Activation of the ERK signaling pathway prevented the up-regulation of GFAP expression. Incubation...

Transient overexpression of alpha-Synuclein in OLN-93 oligodendroglial cells is not cytotoxic and not affected by HSP70 (2007)

Scholz, Petra, Bauer, Nina G, Thiel, Gerald, Richter-Landsberg, Christiane

No abstract available.

Up-regulation of tyrosine hydroxylase gene transcription by tetradecanoylphorbol acetate is mediated by the transcription factors Elk-1 and Egr-1 (2007)

Stefano, Luisa, Al Sarraj, Jude, Rössler, Oliver G, Thiel, Gerald

No abstract available.

Upregulation of Egr-1 biosynthesis in human neuroblastoma cells following activation of epidermal growth factor or muscarinic acetylcholine receptors (2007)

Rössler, Oliver G, Henß, Isabell, Mayer, Manuela, Scheffler, Julia, Thiel, Gerald

No abstract available.

Upregulation of Egr-1 biosynthesis in pituitary gonadotropes following activation of GnRH and muscarinic acetylcholine receptors (2007)

Mayer, Sabine I, Thiel, Gerald

No abstract available.

cAMP response element binding protein (CREB) activates transcription via two distinct genetic elements of the human glucose-6-phosphatase gene (2005)

Thiel, Gerald, Al Sarraj, Jude, Stefano, Luisa

Abstract Background The enzyme glucose-6-phosphatase catalyzes the dephosphorylation of glucose-6-phosphatase to glucose, the final step in the gluconeogenic and glycogenolytic pathways. Expression...

The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor (2003)

Thiel, Gerald, ...

The nuclear protein NIPP1 (nuclear inhibitor of protein Ser/Thr phosphatase-1) interacts with the splicing factors SAP155 and CDC5L and is involved in a late step of spliceosome assembly. In...

cAMP response element binding protein (CREB) activates transcription via two distinct genetic elements of the human glucose-6-phosphatase gene

Thiel, Gerald, Al Sarraj, Jude, Stefano, Luisa

cAMP response element binding protein (CREB) activates transcription via two distinct genetic elements of the human glucose-6-phosphatase gene

Thiel, Gerald, Al Sarraj, Jude, Stefano, Luisa

Blockage of oncostatin M-induced LDL receptor gene transcription by a dominant-negative mutant of C/EBPβ

Zhou, Yue, Zhang, Fang, Abidi, Parveen, Lin, Meihong, Thiel, Gerald, Liu, Jingwen

OM (oncostatin M) activates the human LDLR [LDL (low-density lipoprotein) receptor] gene transcription in HepG2 cells through the SIRE (sterol-independent regulatory element) of LDLR promoter. The...

CREB-1α Is Recruited to and Mediates Upregulation of the Cytochrome c Promoter during Enhanced Mitochondrial Biogenesis Accompanying Skeletal Muscle Differentiation▿ †

Franko, Andras, Mayer, Sabine, Thiel, Gerald, Mercy, Ludovic, Arnould, Thierry, Hornig-Do, Hue-Tran, ...

To further understand pathways coordinating the expression of nuclear genes encoding mitochondrial proteins, we studied mitochondrial biogenesis during differentiation of myoblasts to myotubes. This...

Signal Transduction in the Footsteps of Goethe and Schiller

Friedrich, Karlheinz, Lindquist, Jonathan A, Entschladen, Frank, Serfling, Edgar, Thiel, Gerald, Kieser, Arnd, ...

The historical town of Weimar in Thuringia, the "green heart of Germany" was the sphere of Goethe and Schiller, the two most famous representatives of German literature's classic era. Not yet...

Transcription of Genes Encoding Synaptic Vesicle Proteins in Human Neural Stem Cells: CHROMATIN ACCESSIBILITY, HISTONE METHYLATION PATTERN, AND THE ESSENTIAL ROLE OF REST*

Ekici, Myriam, Hohl, Mathias, Schuit, Frans, Martínez-Serrano, Alberto, Thiel, Gerald

Human HNSC.100 neural stem cells up-regulate expression of GFAP following withdrawal of mitogens. Activation of the ERK signaling pathway prevented the up-regulation of GFAP expression. Incubation of...

Regulation of cellular proliferation, differentiation and cell death by activated Raf

Thiel, Gerald, Ekici, Myriam, Rössler, Oliver G

The protein kinases Raf-1, A-Raf and B-Raf connect receptor stimulation with intracellular signaling pathways and function as a central intermediate in many signaling pathways. Gain-of-function...

Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration, phosphorylation of ERK and activation of ternary complex factor

Rössler, Oliver G, Thiel, Gerald

Tissue-specific regulatory network extractor (TS-REX): a database and software resource for the tissue and cell type-specific investigation of transcription factor-gene networks

Colecchia, Federico, Kottwitz, Denise, Wagner, Mandy, Pfenninger, Cosima V., Thiel, Gerald, Tamm, Ingo, ...

The prediction of transcription factor binding sites in genomic sequences is in principle very useful to identify upstream regulatory factors. However, when applying this concept to genomes of...

Opposing Roles for ATF2 and c-Fos in c-Jun-Mediated Neuronal Apoptosis▿

Yuan, Zhongmin, Gong, Shoufang, Luo, Jingyan, Zheng, Zhihao, Song, Bin, Ma, Shanshan, ...

The activator protein 1 (AP-1) transcription factor c-Jun is crucial for neuronal apoptosis. However, c-Jun dimerization partners and the regulation of these proteins in neuronal apoptosis remain...