Clough, Geraldine F., Turzyniecka, Magdalena, Walter, Lara, Krentz, Andrew J., Wild, Sarah H., Chipperfield, Andrew J., ...
OBJECTIVE: To test the hypotheses that decreased insulin-mediated glucose disposal in muscle is associated with a reduced muscle microvascular exchange capacity (Kf) and that 6 months of high-dose...
Rodford, Joanne L., Torrens, Christopher, Siow, Richard C.M., Mann, Giovanni E., Hanson, Mark A., Clough, Geraldine F.
Endothelial dysfunction underlies cardiovascular disease (CVD) in humans and is reported in animal models of developmental origins of such disease. We have investigated whether impaired antioxidant...
Clough, Geraldine F., Jackson, Claire L., Lee, Jacob J.P., Jamal, Sarah C., Church, Martin K.
This study examined the suitability of microdialysis to assess the time course of cytokine generation from discrete sites within the skin following intradermal injection of allergen. Cytokines were...
Morgan, Caroline J., Friedmann, Peter S., Church, Martin K., Clough, Geraldine F.
Previous studies of the pharmacological regulation of sweat gland function in humans have administered agonists or antagonists systemically, by local intradermal injection or by iontophoresis. This...
Brazís, Pilar, Barandica, Liliana, García, Félix, Clough, Geraldine F., Church, Martin K., Puigdemont, Anna
Dermal microdialysis, a relatively noninvasive technique, allows investigation of the changes in cellular mediators released during cutaneous allergic responses. This technique was used to evaluate...
Morgan, Caroline J., Friedmann, Peter S., Church, Martin K., Clough, Geraldine F.
Previous studies of the pharmacological regulation of sweat gland function in humans have administered agonists or antagonists systemically, by local intradermal injection or by iontophoresis. This...
Brooke, Rebecca C.C., Sinha, Animesh, Sidhu, K., Watson, Rachel E.B., Church, Martin K., Friedmann, Peter S., ...
Acute skin inflammation occurs following topical aminolevulinic acid-photodynamic therapy (ALA-PDT), but its nature and mediation are ill defined. As we observed an urticarial response, a potential...
Rodford, Joanne, Li, Francois Y., Siow, Richard C.M., Hanson, Mark A., Mann, Giovanni E., Clough, Geraldine F.
In rats, restriction of dietary protein during pregnancy leads to raised blood pressure, impaired vasodilatation (Brawley et al. 2003) and increased oxidative damage (increased protein carbonyl...
Torrens, Christopher, Rodford, Joanne L., Wheeler, Timothy, Hanson, Mark A., Clough, Geraldine F.
In the rat, the restriction of dietary protein during pregnancy leads to raised blood pressure and impaired endothelium-dependent vasodilatation in the male offspring (Brawley et al. 2003). Ageing is...
Microdialysis of large molecules (2005)
Microdialysis has been used in many tissues, including skin, brain, adipose tissue, muscle, kidney, and gastrointestinal tract, to recover low–molecular mass endogenous mediators, metabolites, and...
Recovery of nitric oxide from acetylcholine-mediated vasodilatation in human skin in vivo (2004)
Boutsiouki, Paraskevi, Georgiou, Sophia, Clough, Geraldine F.
Objectives: To investigate the relative contribution of nitric oxide (NO) to the vascular and neural mechanisms underlying the ACh-induced vasodilatation in human skin. Methods: ACh was delivered to...
Boutsiouki, Paraskevi, Clough, Geraldine F.
This study investigates whether malathion, a widely used organophosphate insecticide, has its effects on cutaneous vasculature in healthy human volunteers through its anticholinergic activity or...
Winter, Craig D., Pringle, Ashley K, Clough, Geraldine F., Church, Martin K.
Previous studies have suggested that an increased production of the pro‐inflammatory cytokines interleukin‐6 (IL‐6) and interleukin‐1β (IL‐1β) can influence patient outcome...
Winter, Craig D., Pringle, Ashley K, Clough, Geraldine F., Church, Martin K.
Previous studies have suggested that an increased production of the pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-1β (IL-1β) can influence patient outcome following a severe head...
Winter, Craig D., Pringle, Ashley K, Clough, Geraldine F., Church, Martin K.
Previous studies have suggested that an increased production of the pro-inflammatory cytokines interleukin-6 (IL-6) and interleukin-1β (IL-1β) can influence patient outcome following a severe head...
Vascular responses in the skin: an accessible model of inflammation (2002)
Clough, Geraldine F., Church, Martin K.
The skin is the most accessible organ of the human body in which to study the inflammatory process. Until recently, changes in vascular perfusion and permeability could only be superficially...
Winter, Craig D., Iannotti, Fausto, Pringle, Ashley K., Trikkas, Christos, Clough, Geraldine F., Church, Martin K.
Intracerebral microdialysis is used extensively as a research tool in the investigation of the neurochemical and metabolic changes that occur following acute brain injury. Microdialysis has enabled...
Boutsiouki, Paraskevi, Thompson, John P., Clough, Geraldine F.
Malathion [O,O-dimethyl-S-(1,2-dicarbethoxyethyl)phosphorodithioate] is an organophosphorus insecticide widely used in veterinary medicine and in humans for the treatment of lice. In this study, the...
Cole, Zoë A, Clough, Geraldine F, Church, Martin K
This study examines the relative contributions made by inhibition of mast cell degranulation, reduction of mast cell recruitment and maturation, and lowering the responsiveness of the vasculature to...
Role of nitric oxide in the regulation of microvascular perfusion in human skin in vivo
Nitric oxide (NO) concentrations were measured in dialysate from healthy human skin, in vivo, both at rest and during the inflammatory response to intradermal histamine or bradykinin. Changes in...
Rodford, Joanne L, Torrens, Christopher, Siow, Richard C M, Mann, Giovanni E, Hanson, Mark A, Clough, Geraldine F
Endothelial dysfunction underlies cardiovascular disease (CVD) in humans and is reported in animal models of developmental origins of such disease. We have investigated whether impaired antioxidant...
Microdialysis of large molecules
Microdialysis has been used in many tissues, including skin, brain, adipose tissue, muscle, kidney, and gastrointestinal tract, to recover low-molecular mass endogenous mediators, metabolites, and...