Scientific Commons: Gerard J. Mulder

Deuterium Isotope Effect on the Metabolism of the Flame Retardant Tris(2,3-dibromopropyl) Phosphate in the Isolated Perfused Rat Liver (1995)

PEARSON, PAUL G., MEIJER, DIRK K. F., MULDER, GERARD J., NELSON, SIDNEY D., MEERMAN, JOHN H. N.

The metabolism of tris(2,3-dibromopropyl) phosphate (Tris-BP) was compared with that of completely deuterated Tris-BP (D15-Tris-BP) in an isolated, recirculating rat liver perfusion system in order...

Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes (1994)

Kaderlik, Keith R., Mulder, Gerard J., Turesky, Robert J., Lang, Nicholas P., Teitel, Candee H., Chiarelli, M.Paul, ...

The food-borne carcinogenic and mutagenic heterocyclic aromatic amines undergo bioactivation to the corresponding N-hydroxy (OH)-arylamines and the subsequent N-glucuronidation of these metabolites...

Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-l-methyl-6-phenyUmidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues (1994)

Kaderlik, Keith R., Minchin, Rodney F., Mulder, Gerard J., Ilett, Kenneth F., Daugaard-Jenson, Maria, Teitel, Candee H., ...

The food-borne mutagen 2-amino-l-methyl-6-phenylimidazo[ 4,5-b]pyridine (PhIP) induces tumors in colon of male rats and has been implicated in the etiology of human cancers, particularly colorectal...

Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism, PhIP-DNA adduct formation and unscheduled DNA synthesis in primary rat hepatocytes (1994)

Kaderlik, Keith R., Mulder, Gerard J., Shaddock, Joseph G., Casciano, Daniel A., Teitel, Candee H., Kadlubar, Fred F.

The potent rat colon carcinogen 2-amino-l-methyl-6-phenylimidazo[ 4,5-d]pyridine (PhIP), unlike other food-borne heterocyclic amines, does not induce tumors in rat liver. This correlates with an...

Sulfation of hydroxylamines and hydroxamic acids in liver cytosol from male and female rats and purified aryl sulfotransferase IV (1992)

Ringer, David P., Mulder, Gerard J., Meerman, John H.N.

Sulfation activity towards hydroxamic acids and hydroxylamines was determined in liver cytosols for juvenile and adult males and female rats, as well as in purified rat liver aryl sulfotransferase IV...

Photoactivation of 2-nitrofluorene in vitro and in the rat in vivo. UVA-induced formation of reactive intermediates that bind covalently to RNA and protein (1992)

Wierckx, Frank C.J., Van Den Broeke, Leon T., De Vries, Henk, Meerman, John H.N., Mulder, Gerard J.

2-Nitrofluorene (2-NF), an environmental pollutant, can be activated by UV light to reactive intermediates that bind covalently to RNA and protein in vitro: high levels of covalent binding were...

DNA adduct formation in liver following the administration of [3H]2-nitrofluorene to rats in vivo (1991)

Wierckx, Frank C.J., Wedzinga, Rinny, Beland, Frederick A., Meerman, John H.N., Mulder, Gerard J.

The formation of RNA and DNA adducts by the environmental pollutant 2-nitrofluorene (2-NF) has been investigated in rat liver in vivo. The adduct pattern was studied after trifluoroacetic acid...

Conjugation reactions in drug metabolism : an integrated approach : substrates, co-substrates, enzymes and their interactions in vivo and in vitro / edited by Gerard J. Mulder (1990)

Mulder, Gerard J

Incluye bibliografía e índice

The role of N-sulfation in the Nhydroxy-2-acetylaminofluorene-mediated outgrowth of diethylnitrosamine-initiated hepatocytes to {gamma}-glutamyltranspeptidase-positive foci in male rat liver (1988)

Kroese, E. Dinant, Mulder, Gerard J., Meerman, John H. N.

The ability of N-hydroxy-2-acetylaminofluorene (N-OH-AAF) to promote the appearance of γglutamyltranspeptidase-positive (GGT+) foci initiated by diethylnitrosamine (DEN) was studied in a...

Autoradiographic studies on in vivo covalent binding of N-hydroxy-2-acetylaminofluorene in rat liver containing {gamma}-glutamyltranspeptidase-positive foci. The effect of the sulfation-inhibitor pentachlorophenol (1987)

Kroese, E.Dinant, Tijdens, Roeline B., Mulder, Gerard J., Meerman, H.N.

The role of sulfation in the covalent binding of [ring-3H]-N-hydroxy-2-acetylaminofluorene (N-OH-AAF) in rat liver containing γ-glutamyltranspeptldase-positive (GGT+) foci was studied in vivo by...

On the Localisation of d-Tubocurarine in Rat Liver Lysosomes in vivo by Electron Microscopy and Subcellular Fractionation (1975)

Weitering, Jeanette G., Mulder, Gerard J., Meijer, Dirk K.F., Lammers, Wim, Veenhuis, Maarten, Wendelaar Bonga, Sjoerd E.

After i.v. injection in the rat, d-tubocurarine is taken up and concentrated by the liver. A method is developed for the visualisation of d-tubocurarine inside the liver cell by electron microscopy....

Phenol sulphotransferase and uridine diphosphate glucuronyltransferase from rat liver in vivo and in vitro. 2,6-Dichloro-4-nitrophenol as selective inhibitor of sulphation

Mulder, Gerard J., Scholtens, Egbert

Microsomal UDP-glucuronyltransferase and cytosolic sulphotransferase share many substrates, such as phenols and hydroxamic acids. In a search for a selective inhibitor of sulphation, several phenolic...

Metabolism of inorganic sulphate in the isolated perfused rat liver. Effect of sulphate concentration on the rate of sulphation by phenol sulphotransferase

Mulder, Gerard J., Keulemans, Katja

1. The metabolism of inorganic [35S]sulphate (Na235SO4) was studied in the isolated perfused rat liver at three initial concentrations of inorganic sulphate in the perfusion medium (0, 0.65 and...