Germain Puzo

Deglycosylation of the 45/47-Kilodalton Antigen Complex of Mycobacterium tuberculosis Decreases Its Capacity To Elicit In Vivo or In Vitro Cellular Immune Responses

Romain, Félix, Horn, Cynthia, Pescher, Pascale, Namane, Abdelkader, Riviere, Michel, Puzo, Germain, ...

A protection against a challenge with Mycobacterium tuberculosis is induced by previous immunization with living attenuated mycobacteria, usually bacillus Calmette-Guérin (BCG). The 45/47-kDa...

Lipoarabinomannans Activate the Protein Tyrosine Kinase Hck in Human Neutrophils

Astarie-Dequeker, Catherine, Nigou, Jérôme, Puzo, Germain, Maridonneau-Parini, Isabelle

The mycobacterial lipoarabinomannans (LAMs) are glycosylphosphatidyl-myo-inositol-anchored lipoglycans with diverse biological activities. It has been shown that purified LAMs interact directly, or...

Characterization of a Truncated Lipoarabinomannan from the Actinomycete Turicella otitidis

Gilleron, Martine, Garton, Natalie J., Nigou, Jérôme, Brando, Thérèse, Puzo, Germain, Sutcliffe, Iain C.

Lipoarabinomannan (LAM) lipoglycans have been characterized from a range of mycolic acid-containing actinomycetes and from the amycolate actinomycete Amycolatopsis sulphurea. To further understand...

Lipid-restricted recognition of mycobacterial lipoglycans by human pulmonary surfactant protein A: a surface-plasmon-resonance study.

Sidobre, Stéphane, Puzo, Germain, Rivière, Michel

The human pulmonary surfactant protein A (hSP-A), a member of the mammalian collectin family, is thought to play a key defensive role against airborne invading pulmonary pathogens, among which is...

Identification of a novel mannose-capped lipoarabinomannan from Amycolatopsis sulphurea.

Gibson, Kevin J C, Gilleron, Martine, Constant, Patricia, Puzo, Germain, Nigou, Jérôme, Besra, Gurdyal S

The genus Amycolatopsis is a member of the phylogenetic group nocardioform actinomycetes, which also includes the genus Mycobacterium. Members of this group have a characteristic cell envelope...

Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity

Pitarque, Sylvain, Herrmann, Jean-Louis, Duteyrat, Jean-Luc, Jackson, Mary, Stewart, Graham R., Lecointe, François, ...

Interactions between dendritic cells and Mycobacterium tuberculosis, the aetiological agent of tuberculosis in humans, are thought to be central to anti-mycobacterial immunity. We have previously...

Deglycosylation of the 45/47-Kilodalton Antigen Complex of Mycobacterium tuberculosis Decreases Its Capacity To Elicit In Vivo or In Vitro Cellular Immune Responses

Romain, Félix, Horn, Cynthia, Pescher, Pascale, Namane, Abdelkader, Riviere, Michel, Puzo, Germain, ...

A protection against a challenge with Mycobacterium tuberculosis is induced by previous immunization with living attenuated mycobacteria, usually bacillus Calmette-Guérin (BCG). The 45/47-kDa...

Lipoarabinomannans Activate the Protein Tyrosine Kinase Hck in Human Neutrophils

Astarie-Dequeker, Catherine, Nigou, Jérôme, Puzo, Germain, Maridonneau-Parini, Isabelle

The mycobacterial lipoarabinomannans (LAMs) are glycosylphosphatidyl-myo-inositol-anchored lipoglycans with diverse biological activities. It has been shown that purified LAMs interact directly, or...

Characterization of a Truncated Lipoarabinomannan from the Actinomycete Turicella otitidis

Gilleron, Martine, Garton, Natalie J., Nigou, Jérôme, Brando, Thérèse, Puzo, Germain, Sutcliffe, Iain C.

Lipoarabinomannan (LAM) lipoglycans have been characterized from a range of mycolic acid-containing actinomycetes and from the amycolate actinomycete Amycolatopsis sulphurea. To further understand...

Lipid-restricted recognition of mycobacterial lipoglycans by human pulmonary surfactant protein A: a surface-plasmon-resonance study.

Sidobre, Stéphane, Puzo, Germain, Rivière, Michel

The human pulmonary surfactant protein A (hSP-A), a member of the mammalian collectin family, is thought to play a key defensive role against airborne invading pulmonary pathogens, among which is...

Identification of a novel mannose-capped lipoarabinomannan from Amycolatopsis sulphurea.

Gibson, Kevin J C, Gilleron, Martine, Constant, Patricia, Puzo, Germain, Nigou, Jérôme, Besra, Gurdyal S

The genus Amycolatopsis is a member of the phylogenetic group nocardioform actinomycetes, which also includes the genus Mycobacterium. Members of this group have a characteristic cell envelope...

Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity

Pitarque, Sylvain, Herrmann, Jean-Louis, Duteyrat, Jean-Luc, Jackson, Mary, Stewart, Graham R., Lecointe, François, ...

Interactions between dendritic cells and Mycobacterium tuberculosis, the aetiological agent of tuberculosis in humans, are thought to be central to anti-mycobacterial immunity. We have previously...

Endogenous phosphatidylcholine and a long spacer ligand stabilize the lipid-binding groove of CD1b

Garcia-Alles, Luis F, Versluis, Kees, Maveyraud, Laurent, Vallina, Ana Tesouro, Sansano, Sebastiano, Bello, Nana Fatimath, ...

CD1 proteins present lipid antigens to T cells. The antigens are acquired in the endosomal compartments. This raises the question of how the large hydrophobic CD1 pockets are preserved between the...

Diacylated Sulfoglycolipids Are Novel Mycobacterial Antigens Stimulating CD1-restricted T Cells during Infection with Mycobacterium tuberculosis

Gilleron, Martine, Stenger, Steffen, Mazorra, Zaima, Wittke, Frederick, Mariotti, Sabrina, Böhmer, Gabriele, ...

Mycobacterial lipids comprise a heterogeneous group of molecules capable of inducing T cell responses in humans. To identify novel antigenic lipids and increase our understanding of lipid-mediated...

PIM2 Induced COX-2 and MMP-9 Expression in Macrophages Requires PI3K and Notch1 Signaling

Bansal, Kushagra, Kapoor, Nisha, Narayana, Yeddula, Puzo, Germain, Gilleron, Martine, Balaji, Kithiganahalli Narayanaswamy

Activation of inflammatory immune responses during granuloma formation by the host upon infection of mycobacteria is one of the crucial steps that is often associated with tissue remodeling and...